Electrospun Composite Nanofiber Fabrics Containing Uniformly Dispersed Antimicrobial Agents As an Innovative Type of Polymeric Materials with Superior Antimicrobial Efficacy

2010 ◽  
Vol 2 (4) ◽  
pp. 952-956 ◽  
Author(s):  
Xinbo Sun ◽  
Lifeng Zhang ◽  
Zhengbing Cao ◽  
Ying Deng ◽  
Li Liu ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Polymeric Materials ◽  
Antimicrobial Efficacy ◽  
Composite Nanofiber

Collagen Patches Impregnated with Antimicrobial Agents Have High Local Antimicrobial Efficacy and Achieve Effective Tissue Gluing

Infection ◽  
2001 ◽  
Vol 29 (1) ◽  
pp. 27-31 ◽  
Author(s):  
S. Baar ◽  
C. Schörner ◽  
M. Röllinghoff ◽  
M. Radespiel-Tröger ◽  
H.P. Hümmer ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Antimicrobial Efficacy

scholarly journals Evaluation of Antimicrobial Efficacy of Triphala Oral Spray in Patients Undergoing Orthodontic Treatment- A Randomized Clinical Trial

2021 ◽  
pp. 24-29
Author(s):  
Nishi Malviya ◽  
Nilima Thosar ◽  
Nilesh Rathi ◽  
Monika Khubchandani ◽  
V. G. Meshram
Keyword(s):  
Orthodontic Treatment ◽  
Antimicrobial Agents ◽  
Periodontal Diseases ◽  
Drug Formulation ◽  
Microbial Load ◽  
Antimicrobial Efficacy ◽  
Microbial Count ◽  
Oral Streptococci ◽  
Post Intervention ◽  
Plaque Score

Background: Malocclusion is one of the most susceptible causes of the development of periodontal diseases and dental caries in young individuals undergoing fixed orthodontic treatment. It provides a surface area for the accumulation of food particles, which further leads to plaque formation. Various mechanical and chemical aids are used regularly to decrease the microbial load and accumulation of plaque. Chemical adjuncts such as chlorhexidine mouthwash are widely used as antimicrobial agents that have significant efficacy against oral Streptococci and Actinomyces species. Herbal agents have replaced conventional medications due to the development of antibiotic resistance. Among herbal medicaments, Triphala is the well-known drug formulation that can be used as an adjuvant for commercially available chemical aid. Chlorhexidine mouth wash requires the assistance of the caregivers. Therefore, there is a need for a newer modality to maintain oral hygiene in patients undertaking orthodontic corrections. Objectives: 1. To evaluate the antimicrobial efficacy of Triphala oral spray on Streptococcus mutants levels in children undergoing orthodontic treatment. 2. To evaluate the efficacy of Triphala oral spray in reducing dental plaque in children undergoing orthodontic treatment. 3. To evaluate the efficacy of Triphala oral spray reducing gingivitis in children undergoing orthodontic treatment. Methodology: A randomized control trial will be done among – participants with the age group of 10 to 15 years of age. A total of 25 children were included in the study. The participants will be told to use the spray two times a day for one week. After 7 days, plaque index and the gingival index will be re-recorded, and plaque samples will be collected for post-intervention microbial analysis. Results: Triphala-based oral spray will effectively reduce plaque score, reduce gingival inflammation, and show inhibitory effects on microbial count. Conclusion: Triphala oral spray can be used as an adjuvant by the orthodontic patients for reduction of the microbial load. It also provides better acceptability by the children as it does not require any assistance of the caregivers.

scholarly journals Assessment of the half-life of cationic periodontal pocket irrigation

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tugrul Kirtiloglu ◽  
Ilker Keskiner ◽  
Murathan Sahin ◽  
Banu Kirtiloglu ◽  
Safak Aygul ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Half Life ◽  
Antimicrobial Agents ◽  
Dynamic Imaging ◽  
Thallium 201 ◽  
Periodontal Pocket ◽  
Antimicrobial Efficacy ◽  
Clearance Time ◽  
Selection Of

Abstract Background The concentration and persisting time of antimicrobial agents in the periodontal pockets are important factors for their antimicrobial efficacy. Increased clearance time in the periodontal pocket is a significant criterion for the selection of intrapocket irrigants. The aim of this study was to estimate the clearance time of a cationic agent from the periodontal pocket. Methods Thallium-201(Tl-201) was chosen as a tracer to simulate the clearance of cationic substance because of its electrical activity. Twenty patients with periodontitis and probing depths 6 to 9 mm were included in this study. In each patient, 3 Mega Becquerel (MBq) of Tl-201 were inserted into the periodontal pocket. Dynamic imaging was performed and clearance of radioactivity was measured. Results Clearance of radioactivity was 67.1 ± 16.9, 83.1 ± 13.9, 90.4 ± 10.4, 93.39 ± 8.0% at 30, 60, 90 and 120 min, respectively. Half-life of wash-out was determined as 20.3 ± 10.2 min. Conclusion The results of this study demonstrate that the half-life of the cationic solution applied subgingivally was approximately 20 min and labelling of oral irrigants with radiotracers may be used to determine their clearance in further research.

scholarly journals Antimicrobial polymers with immobilized active groups for use in medicine

2019 ◽  
Vol 23 (4) ◽  
pp. 659-666
Author(s):  
V.M. Toropin ◽  
B.V. Murashevych ◽  
H.M. Kremenchutskyi ◽  
D.O. Stepanskyi ◽  
H.S. Maslak ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Antimicrobial Properties ◽  
Physical And Mechanical Properties ◽  
Polymeric Materials ◽  
Wound Dressings ◽  
Woven Fabric ◽  
Laboratory Rats ◽  
Modified Method

Annotation. Polymeric materials with immobilized active groups are widely used in medicine. Some of them have pronounced antimicrobial properties and, to a certain extent, are alternatives to antibiotics. The aim of this research is to study the properties of new polymeric materials with immobilized groups-donors of active chlorine and active oxygen. Polymers of the FIBAN brand in the form of staple fiber and non-woven fabric, which are convenient for the manufacture of dressings, have been used as carriers. A special technology has been developed for the chemical grafting of N-chlorosulfonamide and peroxycarboxylic functional groups on them. The synthesized materials retain appropriate physical and mechanical properties and are stable enough. The antimicrobial activity of these materials has been studied in vitro with the modified method of “agar plates”. It has been proven that all of them have powerful microbicidal properties, especially against S. aureus, which is extremely important, given that these microorganisms are one of the most common multi-resistant pathogens. The antimicrobial and wound healing activity of N-chlorosulfonamide material in vivo has been studied on artificially infected wounds of laboratory rats. The polymer has been used as a component of the sticky wound dressing. It has been found that the use of such dressings reduces the number of pathogenic staphylococci 4–10 times and accelerates reparative processes. Thus, the synthesized polymers with immobilized active groups are effective local antimicrobial agents and can be recommended as components of wound dressings. It is advisable to further study their hemostatic properties, subchronic and chronic toxicity, their effect on basic biochemical parameters, as well as the study of the chemical composition of the different environments that are processed with them.

scholarly journals Evaluation of Antimicrobial Efficacy of Three Combinations of Different Antibiotics against Microorganisms in Gingival Abscess – An in Situ Study

2019 ◽  
pp. 1-7
Author(s):  
Viral Maru Pravin ◽  
Farhin Katge ◽  
Manohar Poojari ◽  
Shilpa K. Shetty
Keyword(s):  
Antimicrobial Agents ◽  
Anaerobic Bacteria ◽  
Antimicrobial Efficacy ◽  
Permanent Teeth ◽  
Primary Tooth ◽  
Dental Arch ◽  
Tooth Root ◽  
Root Canals ◽  
In Situ Study

Background: It is important to maintain primary dentition in the dental arch to facilitate the development of permanent teeth, in spite of teeth with infected root canals. Antimicrobial agents have been used, but, even a broad spectrum antibiotic could not eradicate all the bacteria from the periapical lesions. An in situ study was carried out with the aim to evaluate the antimicrobial efficacy of combinations antibiotics against microorganisms in a gingival abscess or primary tooth root canals. Methodology: Thirty children with gingival abscess secondary to pulp infection or infected primary tooth root canals were randomly selected for the study. Swabs of gingival abscess microbial content were used for development of bacteria in suitable media containing three combinations of antibiotics, under aerobic and anaerobic incubation. Ciprofloxacin, Minocycline were used with metronidazole, ornidazole, tinidazole antibiotics to form three different combinations. The antimicrobial efficacy was measured in terms of the diameter of the zone of inhibition around the antibiotic discs. Results: The three combinations of antibiotics exhibit equivalent efficacy for aerobic as well as anaerobic bacteria, and the difference in efficacy between them was not statistically significant (p > 0.05). There was no difference in pair-wise significance between the groups. Conclusion: In view of the equivalent antibacterial activity of the three classes, towards the two types of bacteria, a group containing ornidazole was found to be superior with more favorable side effect profile compared to metronidazole.

Copper Nanoparticles

2021 ◽  
pp. 370-390
Author(s):  
Ubaid Rasool ◽  
Davoodbasha Mubarak Ali ◽  
Hemalatha S.
Keyword(s):  
Silver Nanoparticles ◽  
Copper Oxide ◽  
Copper Nanoparticles ◽  
Water Purification ◽  
Metallic Nanoparticles ◽  
Bacterial Infections ◽  
Noble Metals ◽  
Antimicrobial Agents ◽  
Metallic Copper ◽  
Antimicrobial Efficacy

Nanoparticles are also proving a great alternative to antibiotics in combating the deadly bacterial infections. Copper nanoparticles, in particular, are being utilized as antimicrobial agents as well as their interaction with other particles helps to improve the antimicrobial efficacy. Compared to other metallic nanoparticles, copper nanoparticles are highly reactive, and their small size allows them to be used in different areas. When exposed to air, copper nanoparticles form copper oxide, and to prevent this oxidation, silica and carbon are utilized to coat copper nanoparticles. Metallic copper nanoparticles have been used in place of silver nanoparticles and other noble metals as anti-infective agents and also utilized in in water purification.

scholarly journals Electrospun Nanomaterials Implementing Antibacterial Inorganic Nanophases

2018 ◽  
Vol 8 (9) ◽  
pp. 1643 ◽  
Author(s):  
Nicoletta Ditaranto ◽  
Francesco Basoli ◽  
Marcella Trombetta ◽  
Nicola Cioffi ◽  
Alberto Rainer
Keyword(s):  
Antimicrobial Agents ◽  
Low Cost ◽  
Polymeric Materials ◽  
Electrospun Fibers ◽  
Multifunctional Materials ◽  
General Aspects

Electrospinning is a versatile, simple, and low cost process for the controlled production of fibers. In recent years, its application to the development of multifunctional materials has encountered increasing success. In this paper, we briefly overview the general aspects of electrospinning and then we focus on the implementation of inorganic nanoantimicrobials, e.g., nanosized antimicrobial agents in electrospun fibers. The most relevant characteristics sought in nanoantimicrobials supported on (or dispersed into) polymeric materials are concisely discussed as well. The interesting literature issued in the last decade in the field of antimicrobial electrospun nanomaterials is critically described. A classification of the most relevant studies as a function of the different approaches chosen for incorporating nanoantimicrobials in the final material is also provided.

scholarly journals Antimicrobial Activity of Monolayer and Multilayer Films Containing Polyhexamethylene Guanidine Sulphanilate

2018 ◽  
Vol 26 (2(128)) ◽  
pp. 73-78 ◽  
Author(s):  
Dorota Gendaszewska ◽  
Lucjan Szuster ◽  
Łucja Wyrębska ◽  
Małgorzata Piotrowska
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Antifungal Activity ◽  
Trichoderma Viride ◽  
Polymeric Materials ◽  
Multilayer Films ◽  
Polyethylene Film ◽  
Antimicrobial Efficacy ◽  
Polyhexamethylene Guanidine

The aim of this study was to determine the antimicrobial properties of multilayer films containing a PHMG sulphanilate (polyhexamethylene guanidine sulphanilate). Three types of films were selected: monolayer and three-layer films (both containing biocide) and market foil. The antibacterial activity of polyethylene film with PHMG sulphanilate was verified based on the guidelines of ISO 22196: 2007 (E): Plastics – Measurement of antibacterial activity on plastic surfaces. The antimicrobial efficacy of the monolayer film against Escherichia coli and Staphylococcus aureus was very good, equalling 6.25 log (100%) and 6.02 log (100%), respectively. It means that a total reduction in bacteria on the surface tested was achieved. The antimicrobial efficacy of the three-layer film against Escherichia coli was satisfactory and equaled 1.32 log (95.2%). The antimicrobial efficacy of this film against Staphylococcus aureus was very good and equaled 6.02 log (100%). The antifungal activity of polyethylene film with PHMG sulphanilate was verified based on the guidelines of ASTM G21 – 96: Standard practice for determining the resistance of synthetic polymeric materials to fungi. The fungal growth of Aspergillus niger, Chaetomium globosum and Trichoderma viride on the monolayer and three layer films was also inhibited, which means that the biocide in the films also exhibits antifungal activities. For the market foil, poor antibacterial efficacy against the bacteria and no antifungal activity against the fungi tested was observed.

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