New Innovative Licensing and Access Pathway for medicines in UK

In line with the government's program to strengthen tourism destinations in Indonesia, many tourism villages have been initiated, including Kulon Progo Regency. The needs of people to relieve fatigue by visiting tourist attractions, encourage the growth of tourist villages. The existence of a tourism village encourages the growth of typical souvenirs of the tourist village. Jatirejo is one of the villages in the Lendah sub-district, Kulon Progo, which is located at 7o93'22" south latitude and between 110o23'08" east longitude. Jatirejo has an area of 635.89 ha or 17.87% of the area of Lendah District (3,559.19 ha). The location of Jatirejo is close to access pathway of NYIA Airport, so it has great potential to become one of the tourism destinations. It is necessary to develop a tourist village by recognizing the agroindustry product potency owned by Jatirejo. This Community Service aimed to recognize and to document the agroindustry product potency of villages, as a first step in the development of local souvenirs and to support the development of Jatirejo Tourism Village. The method used was a field survey and plot the survey results on a map of Jatirejo Village using Corel Draw software. Based on the results of a survey of 5 hamlets in Jatirejo Village, the potential of processed foods that might be developed including emping melinjo, rice plates, catfish product, benguk/koro tempeh, coconut fiber broom, and also chicken cage.

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Correlating biological activity to thermo-structural analysis of the interaction of CTX with synthetic models of macrophage membranes

Scientific Reports ◽

10.1038/s41598-021-02552-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Luciana de Araújo Pimenta ◽

Evandro L. Duarte ◽

Gabriel S. Vignoli Muniz ◽

Kerly Fernanda Mesquita Pasqualoto ◽

Marcos Roberto de Mattos Fontes ◽

...

Keyword(s):

Lipid Membranes ◽

Pore Formation ◽

Biological Activities ◽

Membrane Surface ◽

Membrane Curvature ◽

Structural Alterations ◽

Opening And Closing ◽

Crotalus Durissus ◽

Synthetic Models ◽

Access Pathway

AbstractThe important pharmacological actions of Crotoxin (CTX) on macrophages, the main toxin in the venom of Crotalus durissus terrificus, and its important participation in the control of different pathophysiological processes, have been demonstrated. The biological activities performed by macrophages are related to signaling mediated by receptors expressed on the membrane surface of these cells or opening and closing of ion channels, generation of membrane curvature and pore formation. In the present work, the interaction of the CTX complex with the cell membrane of macrophages is studied, both using biological cells and synthetic lipid membranes to monitor structural alterations induced by the protein. Here we show that CTX can penetrate THP-1 cells and induce pores only in anionic lipid model membranes, suggesting that a possible access pathway for CTX to the cell is via lipids with anionic polar heads. Considering that the selectivity of the lipid composition varies in different tissues and organs of the human body, the thermostructural studies presented here are extremely important to open new investigations on the biological activities of CTX in different biological systems.

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Can an allied health expanded scope Treatment Access Pathway (TAP) improve health outcomes for people with persistent pain? Study protocol for a pragmatic randomised controlled trial

10.21203/rs.2.1749/v1 ◽

2019 ◽

Author(s):

Margaret Anne Vandermost ◽

Michele Sterling ◽

Karl Bagraith ◽

Hannah Kennedy ◽

Darren Doherty ◽

...

Keyword(s):

Cost Effectiveness ◽

Allied Health ◽

Clinical Decision Making ◽

Persistent Pain ◽

Self Report ◽

Control Group ◽

Model Of Care ◽

Treatment Access ◽

Health Crisis ◽

Access Pathway

Abstract Background Persistent pain is a public health crisis. Demand for services frequently exceeds supply and many individuals miss out on timely treatment resulting in longer than recommended wait times. The Interdisciplinary Persistent Pain Centre (IPPC) (Queensland, Australia) implemented a Treatment Access Pathway (TAP), an allied health first point of contact model of care to allow patients access to empirically supported allied health treatment without Pain Specialist assessment. The primary aim of this research project is to understand the clinical and cost effectiveness of TAP in a real-world setting. Method: Participants referred to the IPPC are randomly allocated to treatment or waitlist control groups and self-report and objective physical outcome measures are collected at baseline and 6 months’ time. A total of 196 patients will be recruited for the study (treatment group, n=98 and control group, n=98) to allow a 20% attrition rate to gain 156 participants for the study. Discussion: The results of this study will determine the clinical outcomes and cost effectiveness of the TAP as a model of care to inform future clinical decision making and program development. Ethics approval was provided by the Research Governance Office at Gold Coast Hospital and Health Service (RGOGCHHS) on the 19/10/2016 (HREC/16/QGC/156).

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Latinx Youth’s Funds of Knowledge: Empowering Activist Identities in a Nuevo South College Access Program

Journal of Hispanic Higher Education ◽

10.1177/1538192720963717 ◽

2020 ◽

pp. 153819272096371

Author(s):

Cathryn B. Bennett ◽

Delma Ramos ◽

Rod Wyatt

Keyword(s):

Higher Education ◽

Community Engagement ◽

College Access ◽

Funds Of Knowledge ◽

Qualitative Inquiry ◽

Collective Consciousness ◽

College Access Program ◽

Access Program ◽

Access Pathway

This paper highlights Latinx youth’s community engagement and activist identities during their participation in CHANCE ( Campamento Hispano Abriendo Nuestro Camino a la Educación), a college access program at UNC Greensboro. We examined Latinx youth’s activist identities using critical qualitative inquiry. Findings reveal collective consciousness and responsibility to the Latinx community. Implications and significance for higher education demonstrate how college access pathway programs, such as CHANCE, reinforce Latinx students’ scholar-activist identities.

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Reducing time to angiography and hospital stay for patients with high-risk non-ST-elevation acute coronary syndrome: retrospective analysis of a paramedic-activated direct access pathway

BMJ Open ◽

10.1136/bmjopen-2015-010428 ◽

2016 ◽

Vol 6 (6) ◽

pp. e010428

Author(s):

S Koganti ◽

N Patel ◽

A Seraphim ◽

T Kotecha ◽

M Whitbread ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

High Risk ◽

Hospital Stay ◽

Retrospective Analysis ◽

Direct Access ◽

Coronary Syndrome ◽

St Elevation ◽

Elevation Acute Coronary Syndrome ◽

Access Pathway

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Two ligand-binding sites in CO-reducing V nitrogenase reveal a general mechanistic principle

Science Advances ◽

10.1126/sciadv.abg4474 ◽

2021 ◽

Vol 7 (22) ◽

pp. eabg4474

Author(s):

Michael Rohde ◽

Konstantin Laun ◽

Ingo Zebger ◽

Sven T. Stripp ◽

Oliver Einsle

Keyword(s):

Ligand Binding ◽

Binding Sites ◽

Strong Field ◽

Bound State ◽

Ligand Binding Sites ◽

Hydrocarbon Formation ◽

Co Reduction ◽

Biological Nitrogen ◽

Access Pathway ◽

Specific Ligand

Besides its role in biological nitrogen fixation, vanadium-containing nitrogenase also reduces carbon monoxide (CO) to hydrocarbons, in analogy to the industrial Fischer-Tropsch process. The protein yields 93% of ethylene (C2H4), implying a C–C coupling step that mandates the simultaneous binding of two CO at the active site FeV cofactor. Spectroscopic data indicated multiple CO binding events, but structural analyses of Mo and V nitrogenase only confirmed a single site. Here, we report the structure of a two CO-bound state of V nitrogenase at 1.05 Å resolution, with one μ-bridging and one terminal CO molecule. This additional, specific ligand binding site suggests a mechanistic route for CO reduction and hydrocarbon formation, as well as a second access pathway for protons required during the reaction. Moreover, carbonyls are strong-field ligands that are chemically similar to mechanistically relevant hydrides that may be formed and used in a fully analogous fashion.

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