Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of thyroid autoimmunity: a narrative review

2019 ◽  
Vol 43 (4) ◽  
pp. 413-429 ◽  
Author(s):  
D. Gallo ◽  
L. Mortara ◽  
M. B. Gariboldi ◽  
S. A. M. Cattaneo ◽  
S. Rosetti ◽  
...  
Keyword(s):  
Vitamin D ◽  
Potential Role ◽  
Thyroid Autoimmunity ◽  
Narrative Review ◽  
Immunomodulatory Effect ◽  
Prevention And Treatment

scholarly journals Immunomodulatory Effect of Vitamin D and Its Potential Role in the Prevention and Treatment of Type 1 Diabetes Mellitus—A Narrative Review

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 53 ◽  
Author(s):  
Karolina Rak ◽  
Monika Bronkowska
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Molecular Mechanisms ◽  
Immunological Tolerance ◽  
Narrative Review ◽  
Immunomodulatory Effect ◽  
Transcription Control

Type 1 diabetes mellitus is a chronic autoimmune disease associated with degeneration of pancreatic β-cells that results in an inability to produce insulin and the need for exogenous insulin administration. It is a significant global health problem as the incidence of this disorder is increasing worldwide. The causes are still poorly understood, although it certainly has genetic and environmental origins. Vitamin D formed profusely in the skin upon exposure to sunlight, as well as from dietary sources, exhibits an immunomodulatory effect based on gene transcription control. Indeed, vitamin D can downregulate mechanisms connected with adaptive immunity, induce immunological tolerance and decrease auto-aggression-related inflammation. These properties provide the basis for a preventive and therapeutic role of vitamin D. As many studies have demonstrated, appropriate supplementation with vitamin D reduces the risk of autoimmune diseases, including type 1 diabetes mellitus, and alleviates disease symptoms in patients. The aim of this narrative review is to present the molecular mechanisms for the vitamin D immunomodulatory effect as well as review human clinical studies on the use of vitamin D as adjuvant therapy in type 1 diabetes mellitus.

scholarly journals Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review

2016 ◽  
Vol 174 (11) ◽  
pp. 1378-1394 ◽  
Author(s):  
Arrigo F G Cicero ◽  
Federica Fogacci ◽  
Alessandro Colletti
Keyword(s):  
Chronic Diseases ◽  
Potential Role ◽  
Bioactive Peptides ◽  
Narrative Review ◽  
Prevention And Treatment

Potential role of vitamin D in restoring sensitivity to mTOR inhibitors in hepatocellular carcinoma (HCC): 1,25(OH)vitamin D (VitD) reverts everolimus (EVE) resistance in a hcc cell line

2017 ◽  
Author(s):  
Claudia Pivonello ◽  
Donatella Paola Provvisiero ◽  
Mariarosaria Negri ◽  
Gilda Di Gennaro ◽  
Angelis Cristina de ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Vitamin D ◽  
Cell Line ◽  
Potential Role ◽  
Mtor Inhibitors

scholarly journals Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19

2021 ◽  
Vol 10 (13) ◽  
pp. 2903
Author(s):  
Jiezhong Chen ◽  
Luis Vitetta
Keyword(s):  
Clinical Trials ◽  
Trace Elements ◽  
Gut Microbiota ◽  
Human Health ◽  
Intestinal Microbiota ◽  
Narrative Review ◽  
Bacterial Metabolites ◽  
Gut Dysbiosis ◽  
Prevention And Treatment

The gut microbiota is well known to exert multiple benefits on human health including protection from disease causing pathobiont microbes. It has been recognized that healthy intestinal microbiota is of great importance in the pathogenesis of COVID-19. Gut dysbiosis caused by various reasons is associated with severe COVID-19. Therefore, the modulation of gut microbiota and supplementation of commensal bacterial metabolites could reduce the severity of COVID-19. Many approaches have been studied to improve gut microbiota in COVID-19 including probiotics, bacterial metabolites, and prebiotics, as well as nutraceuticals and trace elements. So far, 19 clinical trials for testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are ongoing. In this narrative review, we summarize the effects of various approaches on the prevention and treatment of COVID-19 and discuss associated mechanisms.

scholarly journals COVID-19: Up to 82% critically ill patients had low Vitamin C values

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Teresa Maria Tomasa-Irriguible ◽  
Lara Bielsa-Berrocal
Keyword(s):  
Vitamin C ◽  
Critically Ill ◽  
Potential Role ◽  
Plasma Vitamin ◽  
Single Center ◽  
Berlin Definition ◽  
Single Center Study ◽  
Prevention And Treatment ◽  
Center Study

AbstractThere are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of critically ill COVID-19 adult patients who met ARDS criteria according to the Berlin definition. This epidemiological study brings to light that up to 82% had low Vitamin C values. Notwithstanding the limitation that this is a single-center study, it nevertheless shows an important issue. Given the potential role of vitamin C in sepsis and ARDS, there is gathering interest of whether supplementation could be beneficial in COVID-19.

scholarly journals A Narrative Review of Early Oral Stepdown Therapy for the Treatment of Uncomplicated Staphylococcus aureus Bacteremia: Yay or Nay?

2020 ◽  
Vol 7 (6) ◽  
Author(s):  
Michael Dagher ◽  
Vance G Fowler ◽  
Patty W Wright ◽  
Milner B Staub
Keyword(s):  
Staphylococcus Aureus ◽  
Hospital Readmission ◽  
Potential Role ◽  
Review Article ◽  
Narrative Review ◽  
Oral Antibiotics ◽  
Staphylococcus Aureus Bacteremia ◽  
Complete Treatment

Abstract Historically, intravenous (IV) antibiotics have been the cornerstone of treatment for uncomplicated Staphylococcus aureus bacteremia (SAB). However, IV antibiotics are expensive, increase the rates of hospital readmission, and can be associated with catheter-related complications. As a result, the potential role of oral antibiotics in the treatment of uncomplicated SAB has become a subject of interest. This narrative review article aims to summarize key arguments for and against the use of oral antibiotics to complete treatment of uncomplicated SAB and evaluates the available evidence for specific oral regimens. We conclude that evidence suggests that oral step-down therapy can be an alternative for select patients who meet the criteria for uncomplicated SAB and will comply with medical treatment and outpatient follow-up. Of the currently studied regimens discussed in this article, linezolid has the most support, followed by fluoroquinolone plus rifampin.

Season of birth and subsequent body size: The potential role of prenatal vitamin D

2010 ◽  
Vol 23 (2) ◽  
pp. 190-200 ◽  
Author(s):  
Marta Krenz-Niedbała ◽  
Elżbieta A. Puch ◽  
Krzysztof Kościński
Keyword(s):  
Vitamin D ◽  
Body Size ◽  
Potential Role ◽  
Season Of Birth

scholarly journals The Potential Role of Vitamin D Enhanced Foods in Improving Vitamin D Status

Nutrients ◽  
2011 ◽  
Vol 3 (12) ◽  
pp. 1023-1041 ◽  
Author(s):  
Louise O’Mahony ◽  
Magdalena Stepien ◽  
Michael J. Gibney ◽  
Anne P. Nugent ◽  
Lorraine Brennan
Keyword(s):  
Vitamin D ◽  
Potential Role ◽  
Vitamin D Status

Effects of vitamin D on parathyroid hormone and clinical outcomes in peritoneal dialysis: a narrative review

2014 ◽  
Vol 27 (5) ◽  
pp. 483-494 ◽  
Author(s):  
Roberto Russo ◽  
Marinella Ruospo ◽  
Mario Cozzolino ◽  
Luca De Nicola ◽  
Andrea Icardi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Peritoneal Dialysis ◽  
Parathyroid Hormone ◽  
Clinical Outcomes ◽  
Narrative Review
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