The relationship of the built and food environments with the metabolic syndrome in the Athens metropolitan area: a sex-stratified spatial analysis in the context of the ATTICA epidemiological study

ObjectiveHigh as well as low levels of IGF1 have been associated with cardiovascular diseases (CVD). The relationship of IGF1 with (components of) the metabolic syndrome could help to clarify this controversy. The aims of this study were: i) to investigate the association of IGF1 concentration with prevalent (components of) the metabolic syndrome; and ii) to examine the role of (components of) the metabolic syndrome in the relationship between IGF1 and incident CVD during 11 years of follow-up.MethodsData were used from the Longitudinal Aging Study Amsterdam, a cohort study in a representative sample of the Dutch older population (≥65 years). Data were available in 1258 subjects. Metabolic syndrome was determined using the definition of the US National Cholesterol Education Program Adult Treatment Panel III. CVD were ascertained by self-reports and mortality data.ResultsLevels of IGF1 in the fourth quintile were associated with prevalent metabolic syndrome compared with the lowest quintile (odds ratio: 1.59, 95% confidence interval (CI) 1.09–2.33). The middle up to the highest quintile of IGF1 was positively associated with high triglycerides in women. Metabolic syndrome was not a mediator in the U-shaped relationship of IGF1 with CVD. Both subjects without the metabolic syndrome and low IGF1 levels (hazard ratio (HR) 1.75, 95% CI 1.12–2.71) and subjects with the metabolic syndrome and high IGF1 levels (HR 2.28, 95% CI 1.21–4.28) demonstrated increased risks of CVD.ConclusionsIn older people, high-normal IGF1 levels are associated with prevalent metabolic syndrome and high triglycerides. Furthermore, this study suggests the presence of different pathomechanisms for both low and high IGF1 levels and incident CVD.

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The relationship of three common definitions of the metabolic syndrome with sub-clinical carotid atherosclerosis

Atherosclerosis ◽

10.1016/j.atherosclerosis.2007.09.007 ◽

2008 ◽

Vol 198 (1) ◽

pp. 228-236 ◽

Cited By ~ 14

Author(s):

Erica Paras ◽

G.B. John Mancini ◽

Scott A. Lear

Keyword(s):

Metabolic Syndrome ◽

Carotid Atherosclerosis ◽

The Metabolic Syndrome ◽

Relationship Of ◽

The Relationship

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Coronary heart disease moderates the relationship of chronic stress with the metabolic syndrome.

Health Psychology ◽

10.1037/0278-6133.17.6.520 ◽

1998 ◽

Vol 17 (6) ◽

pp. 520-529 ◽

Cited By ~ 16

Author(s):

Peter P. Vitaliano ◽

James M. Scanlan ◽

Ilene C. Siegler ◽

Wayne C. McCormick ◽

Robert H. Knopp

Keyword(s):

Metabolic Syndrome ◽

Coronary Heart Disease ◽

Heart Disease ◽

Chronic Stress ◽

The Metabolic Syndrome ◽

Relationship Of ◽

The Relationship

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Racial Differences in the Relationship of Birth Weight to the Metabolic Syndrome in Pre-pubertal Youth

Medicine & Science in Sports & Exercise ◽

10.1249/01.mss.0000273131.00662.ed ◽

2007 ◽

Vol 39 (Supplement) ◽

pp. S59

Author(s):

Melinda S. Sothern ◽

Connie Van Vrancken-Tompkins ◽

Stuart Chalew ◽

William Cefalu ◽

Enette Larson-Meyer ◽

...

Keyword(s):

Metabolic Syndrome ◽

Birth Weight ◽

Racial Differences ◽

The Metabolic Syndrome ◽

Relationship Of ◽

The Relationship

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Metabolic aspects of the relationship of asthma and obesity

Obesity and metabolism ◽

10.14341/omet9578 ◽

2019 ◽

Vol 15 (4) ◽

pp. 9-14 ◽

Cited By ~ 3

Author(s):

Oxana Y. Kytikova ◽

Marina V. Antonyuk ◽

Tatyana A. Gvozdenko ◽

Tatyana Р. Novgorodtseva

Keyword(s):

Nitric Oxide ◽

Insulin Resistance ◽

Metabolic Syndrome ◽

Common Mechanism ◽

The Metabolic Syndrome ◽

Duration Of Hospitalization ◽

Mechanisms Of Formation ◽

Relationship Of ◽

The Relationship

Asthma and obesity are serious medical and social world problems, and their combined course is characterized by a decrease in the quality of life, an increase in the frequency and duration of hospitalization. The present review summarizes the current views on the mechanisms of formation of asthma phenotype combined with obesity, role of leptin and adiponectin imbalance in the development of systemic inflammation in obesity in the pathophysiology of asthma, its interrelations with metabolic syndrome. We present data that shows that syndrome is closely related not only to the debut of asthma, but also to a decrease in its control. Along with obesity, the role of other components of metabolic syndrome, in particular insulin resistance, as a predictor of asthma development is considered. Insulin resistance may be the most likely factor in the relationship between asthma and obesity, independent of other components of the metabolic syndrome. Insulin resistance associated with obesity can lead to disruption of nitric oxide synthesis. We reveal common mechanism of metabolic disorders of nitric oxide and arginine in metabolic syndrome and asthma and show that insulin resistance treatment can be therapeutically useful in patients with asthma in combination with obesity.

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The relationship of heart rate and heart rate variability to non-diabetic fasting glucose levels and the metabolic syndrome: The Cardiovascular Health Study

Diabetic Medicine ◽

10.1111/j.1464-5491.2007.02163.x ◽

2007 ◽

Vol 24 (8) ◽

pp. 855-863 ◽

Cited By ~ 81

Author(s):

P. K. Stein ◽

J. I. Barzilay ◽

P. P. Domitrovich ◽

P. M. Chaves ◽

J. S. Gottdiener ◽

...

Keyword(s):

Metabolic Syndrome ◽

Heart Rate ◽

Cardiovascular Health ◽

Fasting Glucose ◽

Health Study ◽

Cardiovascular Health Study ◽

Glucose Levels ◽

The Metabolic Syndrome ◽

Relationship Of ◽

The Relationship

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Pathogenetic relationship of oral microbiota and obesity in children and adolescents

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) ◽

10.21508/1027-4065-2021-66-5-38-41 ◽

2021 ◽

Vol 66 (5) ◽

pp. 38-41

Author(s):

Yu. G. Samoilova ◽

O. A. Oleynik ◽

D. A. Kudlay ◽

E. V. Sagan ◽

N. S. Denisov

Keyword(s):

Metabolic Syndrome ◽

Gastrointestinal Tract ◽

Conservative Treatment ◽

Taxonomic Diversity ◽

Point Of View ◽

Oral Microbiota ◽

Scientific Interest ◽

The Metabolic Syndrome ◽

Relationship Of ◽

The Relationship

The review summarizes the data of foreign studies on the relationship of the taxonomic diversity of the oral microbiota and changes in its composition with the development of the metabolic syndrome in children with obesity. This information is of scientific interest from the point of view of the search for new targets and possible ways of conservative treatment in order to prevent and treat obesity through maintaining the microflora of the gastrointestinal tract.

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Relationship of acanthosis nigricans with metabolic syndrome in obese children

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0154 ◽

2020 ◽

Vol 33 (12) ◽

pp. 1563-1568

Author(s):

Munise Daye ◽

Beray Selver Eklioglu ◽

Mehmet Emre Atabek

Keyword(s):

Metabolic Syndrome ◽

Acanthosis Nigricans ◽

International Diabetes Federation ◽

Pediatric Endocrinology ◽

Obese Children ◽

Skin Symptom ◽

The Metabolic Syndrome ◽

Patients At Risk ◽

Relationship Of ◽

The Relationship

AbstractObjectivesAcanthosis nigricans is a skin symptom in obesity that helps to identify patients at high risk for dyslipidemia, hypertension, insulin resistance, and diabetes. It is the most important complication of obesity in metabolic syndrome. Studies investigating the relationship between acanthosis nigricans and metabolic syndrome in obese children are insufficient. In our study, the relationship of acanthosis nigricans and metabolic syndrome was evaluated in children.MethodsObese children aged between 6 and 18 years old, who were examined in the pediatric endocrinology outpatient clinic, were included. The patients’ anthropometric measurements and laboratory results were recorded. Modified IDF (International Diabetes Federation) criteria for children were used in metabolic syndrome classification.ResultsA hundred and forty-eight obese children were evaluated. The mean age of the cases was 11.91 ± 2.94 years old. Of the cases, 56.1% were female (n=83) 43.9% (n=65) were male. In 39.9% (n=59) of cases, acanthosis nigricans was determined. Acanthosis nigricans was mostly located in the axillary area (27.1%) and the neck (16.9%). In 55.9% of the cases, it was located in more than one area. The relation of regionally detected acanthosis nigricans and metabolic syndrome was not significant (p=0.291). Metabolic syndrome was detected in 14% of 136 patients according to IDF criteria. Acanthosis nigricans and metabolic syndrome combination was present in 27.7%; however, 6.7% of the metabolic syndrome patients did not have acanthosis nigricans. There was a strong relation between metabolic syndrome and the presence of acanthosis nigricans (p=0.003).ConclusionsIn our study, a correlation between acanthosis nigricans and metabolic syndrome was detected. Acanthosis nigricans is a skin sign that can be easily detected by clinician. It is an important and easy-to-detect dermatosis that helps determine patients at risk of metabolic syndrome in obese children.

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