Mechanical responses of folded structures from the generalized Resch patterns

2021 ◽  
Author(s):  
Zipeng He ◽  
Xiang Zhou
Keyword(s):  
Mechanical Responses ◽  
Folded Structures

Split beam method for determining mode shapes of cantilever beams under multiple loading conditions

2021 ◽  
pp. 107754632110276
Author(s):  
Jun-Jie Li ◽  
Shuo-Feng Chiu ◽  
Sheng D Chao
Keyword(s):  
Operation Mode ◽  
Point Contact ◽  
Mode Shapes ◽  
Cantilever Beams ◽  
Loading Conditions ◽  
Mechanical Responses ◽  
Relative Contribution ◽  
Resonance Frequencies ◽  
Beam Method ◽  
Multiple Loading

We have developed a general method, dubbed the split beam method, to solve Euler–Bernoulli equations for cantilever beams under multiple loading conditions. This kind of problem is, in general, a difficult inhomogeneous eigenvalue problem. The new idea is to split the original beam into two (or more) effective beams, each of which corresponds to one specific load and bears its own Young’s modulus. The mode shape of the original beam can be obtained by linearly superposing those of the effective beams. We apply the split beam method to simulating mechanical responses of an atomic force microscope probe in the “dynamical” operation mode, under which there are a stabilizing force at the positioner and a point-contact force at the tip. Compared with traditional analytical or numerical methods, the split beam method uses only a few number of basis functions from each effective beam, so a very fast convergence rate is observed in solving both the resonance frequencies and the mode shapes at the same time. Moreover, by examining the superposition coefficients, the split beam method provides a physical insight into the relative contribution of an individual load on the beam.

scholarly journals Metamorphic Protein Folding Encodes Multiple Anti-Candida Mechanisms in XCL1

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 762
Author(s):  
Acacia F. Dishman ◽  
Jie He ◽  
Brian F. Volkman ◽  
Anna R. Huppler
Keyword(s):  
Antifungal Drugs ◽  
Surrounding Tissue ◽  
Membrane Disruption ◽  
Antimicrobial Proteins ◽  
Iodide Uptake ◽  
Future Design ◽  
Serious Infections ◽  
Metamorphic Protein ◽  
Folded Structures ◽  
Adenylate Kinase Release

Candida species cause serious infections requiring prolonged and sometimes toxic therapy. Antimicrobial proteins, such as chemokines, hold great interest as potential additions to the small number of available antifungal drugs. Metamorphic proteins reversibly switch between multiple different folded structures. XCL1 is a metamorphic, antimicrobial chemokine that interconverts between the conserved chemokine fold (an α–β monomer) and an alternate fold (an all-β dimer). Previous work has shown that human XCL1 kills C. albicans but has not assessed whether one or both XCL1 folds perform this activity. Here, we use structurally locked engineered XCL1 variants and Candida killing assays, adenylate kinase release assays, and propidium iodide uptake assays to demonstrate that both XCL1 folds kill Candida, but they do so via different mechanisms. Our results suggest that the alternate fold kills via membrane disruption, consistent with previous work, and the chemokine fold does not. XCL1 fold-switching thus provides a mechanism to regulate the XCL1 mode of antifungal killing, which could protect surrounding tissue from damage associated with fungal membrane disruption and could allow XCL1 to overcome candidal resistance by switching folds. This work provides inspiration for the future design of switchable, multifunctional antifungal therapeutics.

scholarly journals Design and Characterization of Microscale Auxetic and Anisotropic Structures Fabricated by Multiphoton Lithography

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 446
Author(s):  
Ioannis Spanos ◽  
Zacharias Vangelatos ◽  
Costas Grigoropoulos ◽  
Maria Farsari
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Mechanical Performance ◽  
Element Analysis ◽  
Mechanical Responses ◽  
Multiphoton Lithography ◽  
Anisotropic Structures ◽  
Scanning Electron

The need for control of the elastic properties of architected materials has been accentuated due to the advances in modelling and characterization. Among the plethora of unconventional mechanical responses, controlled anisotropy and auxeticity have been promulgated as a new avenue in bioengineering applications. This paper aims to delineate the mechanical performance of characteristic auxetic and anisotropic designs fabricated by multiphoton lithography. Through finite element analysis the distinct responses of representative topologies are conveyed. In addition, nanoindentation experiments observed in-situ through scanning electron microscopy enable the validation of the modeling and the observation of the anisotropic or auxetic phenomena. Our results herald how these categories of architected materials can be investigated at the microscale.

scholarly journals Mechanical responses and earthquake activities on tectonic setting of Banda block (case study: Ambon earthquake occurred on September 26, 2019)

2021 ◽  
Author(s):  
Jaya Murjaya ◽  
Dwikorita Karnawati ◽  
Supriyanto ◽  
Rahmat S. Yuliatmoko ◽  
Thomas Hardy ◽  
...  
Keyword(s):  
Tectonic Setting ◽  
Mechanical Responses
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