Colonic inflammation induces changes in glucose levels through modulation of incretin system

Abstract Background The role of the incretin hormone, glucagon-like peptide (GLP-1), in Crohn’s disease (CD), is still poorly understood. The aim of this study was to investigate whether colitis is associated with changes in blood glucose levels and the possible involvement of the incretin system as an underlaying factor. Methods We used a murine model of colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Macroscopic and microscopic score and expression of inflammatory cytokines were measured. The effect of colitis on glucose level was studied by measurement of fasting glucose and GLP-1, dipeptidyl peptidase IV (DPP IV) levels, prohormone convertase 1/3 (PC 1/3) and GLP-1 receptor (GLP-1R) expression in mice. We also measured the level of GLP-1, DPP IV and expression of glucagon (GCG) and PC 1/3 mRNA in serum and colon samples from healthy controls and CD patients. Results Fasting glucose levels were increased in animals with colitis compared to controls. GLP-1 was decreased in both serum and colon of mice with colitis in comparison to the control group. DPP IV levels were significantly increased in serum, but not in the colon of mice with colitis as compared to healthy animals. Furthermore, PC 1/3 and GLP-1R expression levels were increased in mice with colitis as compared to controls. In humans, no differences were observed in fasting glucose level between healthy subjects and CD patients. GLP-1 levels were significantly decreased in the serum. Interestingly, GLP-1 level was significantly increased in colon samples of CD patients compared to healthy subjects. No significant differences in DPP IV levels in serum and colon samples were observed between groups. Conclusions Changes in the incretin system during colitis seem to contribute to the impaired glucose levels. Differences in incretin levels seem to be modulated by degrading enzyme DPP-IV and PC 1/3. Obtained results suggest that the incretin system may become a novel therapeutic approach in the treatment of CD.

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EFFECTIVENESS OF AMLA JUICE IN REDUCING BLOOD GLUCOSE LEVEL AMONG PATIENTS WITH TYPE II DIABETES IN A SELECTED AREA OF KANYAKUMARI DISTRICT

THE RESEARCH RESERVOIR ◽

10.47211/trr.2021.v07i01.012 ◽

2021 ◽

Vol 7 (1) ◽

Author(s):

Mrs. Vanitha. S s ◽

Dr. Pramjit kaur

Keyword(s):

Blood Glucose ◽

Standard Deviation ◽

Blood Glucose Level ◽

Glucose Level ◽

Type Ii Diabetes ◽

Control Group ◽

Type Ii ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Experimental Group

Challenges in lifestyle, such as increasesin energy intake and decreasesin physical activity are causing overweight and obesity leading to epidemic increases in type II Diabetes Mellitus. The research approach used for this study was evaluative approach and the research design was true experimental design. 60 patients with type II diabetes, 30 in experimental group and 30 in control group were selected for this study by using purposive sampling technique. Data was collected with the help of self-structured interview schedule. Descriptive statistics (frequency, percentage, mean and standard deviation) and inferential statistics (chi-square, paired ‘t’ test) were used to analyse the data and to test the hypotheses. In the experimental group,the pre-test mean score was 2.966, mean percentage was 59% and standard deviation was 1.129 and in post-testmean score was 2.533, mean percentage was 50.66% and standard deviation was 1.074 with effectiveness of 8.34% and paired‘t’ test value of t=3.971,which was statistically significant (p<0.05) which is an evidence ofthe effectiveness of Amla juice in reducing blood glucose level. Comparison of blood glucose levels in experimental and control groups, shows that the value is statistically highly significant, as was observed from the unpaired ‘t’ test value of 13.39 with P value of <0.05, which is an evidence indicatingthe effect of Amla juice in reducing postprandial blood glucose levels. The resultsfound that the administration of Amla juice did have aneffect in reducing blood glucose level in the experimental group. By comparing the findings of pre-test and post test between the experimental group and the control group,the effect was identified (assessed). The study concluded that the Amlajuice is effective in reducing blood glucose level.

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Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.00564.2010 ◽

2011 ◽

Vol 301 (2) ◽

pp. E274-E280 ◽

Cited By ~ 27

Author(s):

Koji Sato ◽

Motoyuki Iemitsu ◽

Katsuji Aizawa ◽

Noboru Mesaki ◽

Satoshi Fujita

Keyword(s):

Protein Kinase ◽

Exercise Training ◽

Fasting Glucose ◽

Serum Insulin ◽

Control Group ◽

Glucose Levels ◽

Diet Induced Obesity ◽

Blood Glucose Levels ◽

Male Wistar Rats ◽

Dhea Treatment

This study was undertaken to assess the effects of dehydroepiandrosterone (DHEA) administration and exercise training on muscular DHEA and 5α-dihydrotestosterone (DHT) levels and hyperglycemia in diet-induced obese and hyperglycemic rats. After 14 wk of a high-sucrose diet, obese male Wistar rats were assigned randomly to one of three 6-wk regimens: control, DHEA treatment, or exercise training (running at 25 m/min for 1 h, 5 days/wk; n = 10 each group). Results indicate that either 6 wk of DHEA treatment or exercise training significantly attenuated serum insulin and fasting glucose levels compared with the control group. Plasma and muscle concentrations of DHEA and DHT and expression levels of 5α-reductase were significantly higher in the DHEA-treated and exercise-training groups. Moreover, both DHEA administration and exercise training upregulated GLUT4 translocation with concomitant increases in protein kinase B and protein kinase Cζ/λ phosphorylation. Muscle DHEA and DHT concentrations closely correlated with blood glucose levels (DHEA treatment: r = −0.68, P < 0.001; exercise training: r = −0.65, P < 0.001), serum insulin levels, and activation of the GLUT4-regulated signaling pathway. Thus, increased levels of muscle sex steroids may contribute to improved fasting glucose levels via upregulation of GLUT4-regulated signaling in diet-induced obesity and hyperglycemia.

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The Effect of Belimbing Wuluh (Averrhoa Bilimbi L.) and Red Guava (Psidium Guajava L.) Extract on Fasting Blood Glucose Levels of Diabetic Wistar Rats Model

Journal of Agromedicine and Medical Sciences ◽

10.19184/ams.v5i2.12076 ◽

2019 ◽

Vol 5 (2) ◽

pp. 57

Author(s):

Yesi Warisman ◽

Arinda Lironika Suryana ◽

Zora Olivia

Keyword(s):

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Wistar Rats ◽

Fasting Blood Glucose ◽

Diabetic Rats ◽

Control Group ◽

Standard Diet ◽

Glucose Levels ◽

Blood Glucose Levels

Diabetes mellitus is a metabolic disease with special characteristic which increased blood glucose level (hiperglicemic), its happens because of the abnormality of insulin secretion, insulin mechanisme or both of them. Belimbing wuluh and red guava extract can become alternative functional drink that contain rich of vitamin C to help controlling blood glucose level. The aimed of this study was to determined the effect of belimbing wuluh and red guava extract on blood glucose levels of Rattus novergicus strain Wistar diabetic model. This research was an true experimental study with a randomized post-test control group design. Twentyfour (24) male wistar strain rats weighing 200-250 grams, aged 2-3 months, were divided into 4 groups. The control group (K-) non-diabetic rats, the control group (K+) diabetic rats given standard diet, and the treatment group diabetic rats given standard diet and belimbing wuluh and red guava extract intervetion doses 10,7 ml/day (P1) and 21ml/day (P2). Measurement of pretest posttest fasting blood glucose levels was carried out using biolyzer. The data were analyzed by One Way Anova test. The results showed that there were significant differences in delta pretest and posttest fasting blood glucose levels between all groups. Blood glucose levels decreased at 55.6%. In conclusion, belimbing wuluh and red guava extract 21ml/day most effectively decreased fasting blood glucose levels in diabetic wistar rats moldel. Keywords: belimbing wuluh, blood glucose level, diabetes mellitus, red guava

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Chitosan oligosaccharide (GO2KA1) improves postprandial glycemic response in subjects with impaired glucose tolerance and impaired fasting glucose and in healthy subjects: a crossover, randomized controlled trial

Nutrition and Diabetes ◽

10.1038/s41387-019-0099-4 ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 6

Author(s):

Sarang Jeong ◽

Jung Min Cho ◽

Young-In Kwon ◽

Seong-Chul Kim ◽

Dong Yeob Shin ◽

...

Keyword(s):

Blood Glucose ◽

Glucose Tolerance ◽

Impaired Glucose Tolerance ◽

Healthy Subjects ◽

Fasting Glucose ◽

Test Group ◽

Postprandial Blood Glucose ◽

Chitosan Oligosaccharide ◽

Glucose Levels ◽

Blood Glucose Levels

Abstract Background The antidiabetic and hypoglycemic effects of chitosan have been reported in previous studies. We have previously shown that chitosan oligosaccharide reduces postprandial blood glucose levels in vivo. We conducted a short-term crossover study to support the results of the previous study. Methods The study was a randomized, double-blind, controlled crossover trial completed at one clinical research site. Subjects with impaired glucose tolerance and impaired fasting glucose and healthy subjects were randomly assigned to consume one of two different experimental test capsules that differed in only the sample source (GO2KA1 vs placebo), and all subjects were instructed to consume the 75 g sucrose within 15 min. After a 7-day interval, the subjects consumed the other capsules that were not consumed on the first day. We assessed blood glucose levels using a 2-h oral sucrose tolerance test. The study was registered at clinicaltrials.gov (NCT03650023). Results The test group showed significantly lower blood glucose levels at 60 min (p = 0.010) and postprandial blood glucose areas under the curve (p = 0.012). The change in blood glucose levels at 60 min was significantly lower in the test group than in the placebo group (p = 0.017). Conclusions Based on the results of this study, the consumption of chitosan oligosaccharide (GO2KA1) supplements with a meal can effectively reduce postprandial blood glucose levels, which is relevant to the prevention of diabetes.

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Perceived food palatability, blood glucose level and future discounting: Lack of evidence for blood glucose level’s impact on reward discounting

PLoS ONE ◽

10.1371/journal.pone.0255484 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0255484

Author(s):

Rafał Muda ◽

Przemysław Sawicki ◽

Michał Ginszt

Keyword(s):

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Control Group ◽

Palatable Food ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Future Discounting ◽

Moderating Role ◽

Experimental Group

Some previous studies have shown that an increase in blood glucose level makes people more future oriented, however, results are inconsistent, other studies failing to replicate this effect. Here, we tested whether psychological factors (in this instance, perception of food pleasantness after consumption of more palatable or less palatable meal) can play a moderating role. We hypothesized that consuming more palatable food (perceived as rewarding) should cause blood glucose levels to affect future discounting, but that this should not occur for the consumption of less palatable food. A high-powered, independent groups experiment (N = 149, power β = .90) showed that, subsequent to performing an initial discounting task, the two groups consuming a meal (a control group consumed no meal) displayed a significant increase in blood glucose levels 10 minutes after meal consumption and just before repeating the discounting task. However, the increased blood glucose levels did not cause changes in delay discounting in either experimental group.

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The effect of lycopene treatment on ACE activity in rats with experimental diabetes

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320311426024 ◽

2012 ◽

Vol 13 (3) ◽

pp. 328-333 ◽

Cited By ~ 11

Author(s):

Serif Ozmutlu ◽

Semiha Dede ◽

Ebubekir Ceylan

Keyword(s):

Diabetes Complications ◽

Experimental Diabetes ◽

Treated Group ◽

Control Group ◽

Diabetes Group ◽

Important Indicator ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Ace Activity

In this study, the anti-inflammatory and antioxidant known as lycopene was applied to rats with experimental diabetes with the aim of investigating the detection of diabetes-related complications, and to determine the possible role of lycopene in diabetes complications regarding the effects of ACE activity. In order to induce diabetes in rats in the diabetes (D) and diabetes+lycopene (DL) groups, rats were given 45 mg/kg single-dose streptozotocin (STZ) intraperitoneally (i.p.); lycopene (10 mg/kg/day dissolved in sunflower oil) was administered to the rats in the lycopene-only (L) and DL groups. Blood glucose levels and HbA1c% in diabetes+lycopene group and diabetes group increased (p <0.05) compared to control and only lycopene treated group. The highest level of ACE activity was observed in the (D) group ( p < 0.05). Activity in the (L) group was also significantly greater than in the control group ( p < 0.05). The (DL) group had lower ( p < 0.05). ACE activity than the (D) group. Lycopene implementation was found to be effective in the inhibition of ACE activity, an important indicator of diabetes-related complications.

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The effect of daun sendok (Plantago major) extract on the blood glucose level of Balb/C mice induced by streptozotocin

Biofarmasi Journal of Natural Product Biochemistry ◽

10.13057/biofar/f080205 ◽

2010 ◽

Vol 8 (2) ◽

pp. 66-71

Author(s):

PUTRI SATRIANY ◽

R. P. ANDRI PUTRANTO ◽

IPOP SYARIFAH

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Simple Random Sampling ◽

Control Group ◽

Plantago Major ◽

Control Group Design ◽

Glucose Levels ◽

Blood Glucose Levels

Satriany P, Putranto RPA, Syarifah I. 2010. The effect of daun sendok (Plantago major) extract on the blood glucose level of Balb/C mice induced by streptozotocin. Biofarmasi 8: 66-71. This research aimed to determine the effect of daun sendok (Plantago major L.) extract on the blood glucose level of Balb/C mice induced by streptozotocin. This study was a laboratory experimental pre and post-test control group design. The subjects used were 16 male mice. Then, mice were induced with streptozotocin by a dose of 65 mg/kg body weight intraperitoneally freshly dissolved in 0.02 M citrate saline buffer. Mice used were mice with blood glucose levels â‰¥200 mg/dL. Furthermore, mice were divided into 2 groups by a simple random sampling. Group 1 was given metformin in a dose of 1.3 mg/mice/day and group 2 was given daun sendok extract in a dose of 1000 mg/kg body weight/day. At the 2nd week, it was measured for the glucose levels from the blood of mice tail by a Blood Glucose Stick Meter (Gluco DrTM). The data obtained were statistically analyzed by independent samples t-test by using SPSS Programme for Microsoft Windows release 17.0. The significance was set at p<0.05. The difference of average blood glucose levels pre vs post experiment, metformin group was -145.87 mg/dL and daun sendok group was -85.00 mg/dL (p=0.024). The experiment results showed that daun sendok extract in a dose of 1000 mg/kg body weight/day could reduce the blood glucose levels in Balb/C mice induced by streptozotocin.

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Pemberian ekstrak air buah sawo (Manilkara zapota L.) menurunkan kadar glukosa darah tikus (rattus norvegicus) diabetes mellitus

Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) ◽

10.21927/ijnd.2015.3(3).180-186 ◽

2016 ◽

Vol 3 (3) ◽

pp. 180

Author(s):

Effatul Afifah

Keyword(s):

Diabetes Mellitus ◽

Body Weight ◽

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Control Group ◽

Control Group Design ◽

Group Design ◽

Glucose Levels ◽

Blood Glucose Levels

ABSTRACT Background: Diabetes mellitus (DM) is a chronic metabolic problem disorder characterized by hyperglicemia which is caused by insulin deficiency produced by β-pancreas cells, thus causing abnormalities of carbohydrate, protein, and fat metabolism, and tend to cause complications. Objectives: To know the effect of sapodilla extract water on blood glucose level of diabetic induce mice. Methods: This was an experimental study with pre-post control group design. Sapodilla extract water (EABS) was fed to group of mice with alloxan diabetes induction. Twenty four DM induced mice were separated into 4 groups, e.g. control without and with medication of glibenclamide, EABS 1 (treated with 3.6 mL/200 g body weight), and EABS 2 (treated with 7.2 mL/200 g body weight). Mice were then measured for their blood glucose level at the day of 3, 14, and 30. Results: EABS 1 and EABS 2 decreased blood glucose levels at week of 1st, 2nd, and 3rd after induction. The greatest reduction was shown by EABS 2 at the 3rd week. EABS decreased blood glucose level of mice induced DM and signifi cantly shown at glibenclamide group, followed by EABS 2 and EABS 1.Conclusions: EABS reduced blood glucose levels of diabetic mice and signifi cantly shown for glibenclamide group, followed by EABS 2 and EABS 1.KEYWORDS: diabetes mellitus, sapodilla extract water, blood glucose ABSTRAKLatar belakang: Diabetes mellitus (DM) merupakan penyakit gangguan metabolik kronis yang ditandai dengan hiperglikemia yang disebabkan oleh kekurangan insulin yang dihasilkan oleh sel β-pankreas sehingga menimbulkan kelainan metabolisme karbohidrat, protein dan lemak, dan cenderung menimbulkan komplikasi.Tujuan: Mengetahui efek pemberian ekstrak buah air sawo terhadap kadar glukosa darah tikus yang diinduksi DM.Metode: Penelitian ini merupakan penelitian eksperimental murni dengan rancangan pre-post test control group design dengan memberikan intervensi ekstrak buah air sawo (EABS) pada kelompok tikus yang diberikan induksi DM menggunakan aloksan. Sebanyak 24 tikus yang diinduksi DM dikelompokkan ke dalam 4 perlakuan, antara lain kontrol tanpa dan dengan pengobatan glienclamide, EABS 1 (diberi 3,6 mL/200 g berat badan), dan EABS 2 (7,2 mL/200 g berat badan). Tikus diukur kadar gula darahnya pada hari ke-3, 14, dan 30. Hasil: EABS mampu menurunkan kadar glukosa darah pada tikus, baik pada kelompok EABS 1 maupun EABS 2 pada minggu ke-1, ke-2, dan ke-3 setelah induksi. Hasil penurunan kadar glukosa yang paling besar terjadi pada kelompok EABS 2 pada minggu ke-3 perlakuan. EABS dapat menurunkan kadar glukosa darah tikus yang diinduksi DM dan paling signifi kan terjadi pada kelompok glibenclamide diikuti oleh EABS 2 dan EABS 1.Kesimpulan: EABS mampu menurunkan kadar glukosa darah pada tikus yang diinduksi alloxan.KATA KUNCI: diabetes mellitus, ekstrak air buah sawo, glukosa darah

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Uji efek air perasan albedo semangka kuning (Citrilus lanatus (Thunb.) Matsum. & Nakai) terhadap kadar glukosa darah pada tikus wistar (Rattus norvegicus) yang diinduksi aloksan

Jurnal e-Biomedik ◽

10.35790/ebm.4.1.2016.12149 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

Savitri Muhammad Nur ◽

Henoch Awaloei ◽

Jane Wuisan

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Blood Glucose Level ◽

Glucose Level ◽

Wistar Rats ◽

White Layer ◽

Negative Control ◽

Control Group ◽

Glucose Levels ◽

Blood Glucose Levels

Abstract: Indonesian has various natural resources, second as largest after Brazil. One of the traditional medicine that has been used is watermelon. The part of watermelon that is known to be used as medicine is its white layer between the peel and the fruit, albedo. This study aimed to determine the effect of yellow watermelon albedo juice on blood glucose levels in wistar rats induced by alloxan. Subjects consisted of 18 male Wistar rats divided into 6 groups as follows: a negative control group, 3 groups of hyperglycemic rats induced with alloxan 120 mg/kg body weight; and 2 groups given only yellow watermelon albedo juice. Hyperglycemic rats were given yellow watermelon albedo with dose of 9 g/kg body weight and 4,5 g/kg body weight; positive control group was given novomix; and two other groups were given only yellow watermelon albedo juice. Blood glucose levels of each rat were evaluated on day 1, day 2, and day 3 before the treatment after 6 hours, 12 hours, 18 hours, 24 hours. The results showed that administration of yellow watermelon albedo juice 9 g/kg body weight of Wistar rats reduced the blood glucose level until 126.67 mg/dl, meanwhile the dose 4.5 g/kg body weight reduced the blood glucose level until 173.67 mg/dl. Conclusion: Administration of yellow watermelon albedo juice of 9 g/kg body weight and 4.5 g/kg body weight could reduce blood glucose levels of hyperglycemic Wistar rats induced by alloxan. Keywords: yellow watermelon albedo, hyperglycemia, blood glucose level Abstrak: Indonesia merupakan negara yang memiliki keanekaragaman hayati terkaya kedua didunia setelah Brazil. Salah satu obat tradisional yang digunakan ialah buah semangka. Bagian dari semangka yang digunakan ialah lapisan yang berwarna putih yakni antara kulit dan daging buah semangka disebut albedo. Penelitian ini bertujuan untuk menguji pengaruh pemberian air perasan albedo semangka kuning terhadap kadar glukosa darah pada tikus wistar yang diinduksi aloksan. Subjek penelitian yaitu 18 ekor tikus Wistar jantan yang dibagi menjadi 6 kelompok, yaitu: kelompok kontrol negatif; 3 kelompok tikus Wistar hiperglikemik yang diinduksi aloksan dengan dosis 120 mg/kg BB; dan 2 kelompok tikus Wistar yang hanya diberikan albedo semangka kuning. Kelompok tikus yang hiperglikemik diberi albedo semangka kuning dengan dosis 9 g/kg BB dan 4,5 g/kg BB; kelompok kontrol positif diberikan novomix; dan 2 kelompok hanya diberikan albedo semangka kuning. Pemeriksaan kadar glukosa darah dari semua kelompok tikus Wistar dilakukan pada hari ke-1, hari ke-2, dan hari ke-3 pada jam ke 0, 6, 12, 18, dan 24. Hasil penelitian memperlihatkan pemberian air perasan albedo semangka kuning dosis 9 g/kg BB dapat menurunkan kadar glukosa darah sebanyak 126,67 mg/dl sedangkan dosis 4,5 g/kg BB sebanyak 173,67 mg/dl. Simpulan: Air perasan albedo semangka kuning dengan dosis 9 g/kg BB dan 4,5 g/kg BB dapat menurunkan kadar glukosa darah tikus Wistar hiperglikemik yang diinduksi aloksan.Kata kunci: albedo semangka kuning, hipeglikemi, kadar glukosa darah

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PENGARUH PEMBERIAN FRAKSI ETILASETAT KULIT UBI JALAR UNGU TERHADAP KADAR MALONDIALDEHID (MDA) SERUM MENCIT PUTIH JANTAN HIPERGLIKEMIA

SCIENTIA : Jurnal Farmasi dan Kesehatan ◽

10.36434/scientia.v8i2.170 ◽

2018 ◽

Vol 8 (2) ◽

pp. 144

Author(s):

Ria Afrianti

Keyword(s):

Blood Glucose ◽

Statistical Analysis ◽

Sweet Potato ◽

Ethyl Acetate Fraction ◽

Serum Levels ◽

Negative Control ◽

Control Group ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Purple Sweet Potato

This study aims to determine the effect giving of ethylacetate fraction of leather purple sweet potato (Ipomoea batatas (L.) Lam, on levels of malondialdehyde (MDA) serum in mice hyperglicemia were induced with streptozocin dose of 50 mg/kgBW. Mice were divided into 5 groups, each group consisting of 3 tails, group I is a negative control, group II is a positive control, group III,IV and V is given ethylacetate fraction a dose of 100 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. Ethyl Acetate Fraction leather purple sweet potato given orally for 15 days after the animal is declared hyperglicemia and measurement of blood glucose levels on 5, 10, and 15 day after giving test preparation in animal experiments. On the 16 day throughout the mice were taken serum levels measured malondialdehid. The statistical analysis results showed that giving of ethyl acetate fraction of leather purple sweet potato at a dose of 100 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW can lower blood glucose levels in mice hyperglycemia significantly (p<0.05). Malondialdehid levels on average in each group is 1.35 nmol/ml, 3.00 nmol/ml, 2.72 nmol/ml, 2.20 nmol/ml and 2.61 nmol/ml, the results of statistical analysis showed a decrease in melondialdehid serum levels were significantly (p<0.05), where a dose of 300 mg/kgBW is an effective dose for lowering blood glucose levels followed by decreased levels of malondialdehid which give effect approaching negative control.

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