Influence of the rate of force application on the absolute psychophysical threshold level of periodontal mechanoreceptors in man

1983 ◽  
Vol 28 (8) ◽  
pp. 659-663 ◽  
Author(s):  
W.H. Schoo ◽  
D. van Steenberghe ◽  
J.H. de Vries
Keyword(s):  
Threshold Level ◽  
Force Application ◽  
Periodontal Mechanoreceptors ◽  
Psychophysical Threshold ◽  
The Absolute

scholarly journals Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse

2019 ◽  
Vol 5 (4) ◽  
pp. eaav9824 ◽  
Author(s):  
R. Filograna ◽  
C. Koolmeister ◽  
M. Upadhyay ◽  
A. Pajak ◽  
P. Clemente ◽  
...  
Keyword(s):  
Copy Number ◽  
Important Determinant ◽  
Threshold Level ◽  
Wild Type ◽  
Mtdna Copy Number ◽  
Mtdna Mutation ◽  
Mtdna Mutations ◽  
Selective Elimination ◽  
The Absolute ◽  
Or Gene

Heteroplasmic mtDNA mutations typically act in a recessive way and cause mitochondrial disease only if present above a certain threshold level. We have experimentally investigated to what extent the absolute levels of wild-type (WT) mtDNA influence disease manifestations by manipulating TFAM levels in mice with a heteroplasmic mtDNA mutation in the tRNAAla gene. Increase of total mtDNA levels ameliorated pathology in multiple tissues, although the levels of heteroplasmy remained the same. A reduction in mtDNA levels worsened the phenotype in postmitotic tissues, such as heart, whereas there was an unexpected beneficial effect in rapidly proliferating tissues, such as colon, because of enhanced clonal expansion and selective elimination of mutated mtDNA. The absolute levels of WT mtDNA are thus an important determinant of the pathological manifestations, suggesting that pharmacological or gene therapy approaches to selectively increase mtDNA copy number provide a potential treatment strategy for human mtDNA mutation disease.

Bulk standards for low-temperature biological x-ray microanalysis

1984 ◽  
Vol 42 ◽  
pp. 282-283
Author(s):  
P. Echlin ◽  
M. McKoon ◽  
E.S. Taylor ◽  
C.E. Thomas ◽  
K.L. Maloney ◽  
...  
Keyword(s):  
Phase Separation ◽  
Low Temperature ◽  
Analytical Method ◽  
Salt Solutions ◽  
Absolute Concentration ◽  
Cooling Process ◽  
X Ray ◽  
The Absolute ◽  
Analytical Procedures ◽  
Electrical Conductors

Although sections of frozen salt solutions have been used as standards for x-ray microanalysis, such solutions are less useful when analysed in the bulk form. They are poor thermal and electrical conductors and severe phase separation occurs during the cooling process. Following a suggestion by Whitecross et al we have made up a series of salt solutions containing a small amount of graphite to improve the sample conductivity. In addition, we have incorporated a polymer to ensure the formation of microcrystalline ice and a consequent homogenity of salt dispersion within the frozen matrix. The mixtures have been used to standardize the analytical procedures applied to frozen hydrated bulk specimens based on the peak/background analytical method and to measure the absolute concentration of elements in developing roots.

A Quantitative Ultrastructural Study of Peripheral Blood Lymphocytes Containing Parallel Tubular Arrays in Epstein-Barr Virus and Cytomegalo-Virus Mononucleosis

1981 ◽  
Vol 39 ◽  
pp. 454-455
Author(s):  
C. M. Payne ◽  
P. M. Tennican
Keyword(s):  
Peripheral Blood ◽  
Lymphocyte Count ◽  
Epstein Barr Virus ◽  
Absolute Lymphocyte Count ◽  
Peripheral Blood Lymphocytes ◽  
Clinical State ◽  
Barr Virus ◽  
The Absolute ◽  
Epstein Barr ◽  
Tubular Arrays

In the normal peripheral circulation there exists a sub-population of lymphocytes which is ultrastructurally distinct. This lymphocyte is identified under the electron microscope by the presence of cytoplasmic microtubular-like inclusions called parallel tubular arrays (PTA) (Figure 1), and contains Fc-receptors for cytophilic antibody. In this study, lymphocytes containing PTA (PTA-lymphocytes) were quantitated from serial peripheral blood specimens obtained from two patients with Epstein -Barr Virus mononucleosis and two patients with cytomegalovirus mononucleosis. This data was then correlated with the clinical state of the patient.It was determined that both the percentage and absolute number of PTA- lymphocytes was highest during the acute phase of the illness. In follow-up specimens, three of the four patients' absolute lymphocyte count fell to within normal limits before the absolute PTA-lymphocyte count.In one patient who was followed for almost a year, the absolute PTA- lymphocyte count was consistently elevated (Figure 2). The estimation of absolute PTA-lymphocyte counts was determined to be valid after a morphometric analysis of the cellular areas occupied by PTA during the acute and convalescent phases of the disease revealed no statistical differences.

Polarity Determination in Sphalerite and Wurtzite Structures

1990 ◽  
Vol 48 (2) ◽  
pp. 500-501
Author(s):  
Stuart McKernan ◽  
C. Barry Carter
Keyword(s):  
Opposite Polarity ◽  
Single Domain ◽  
Polar Material ◽  
Electron Microscopic ◽  
Dynamical Interaction ◽  
X Ray ◽  
Polarity Determination ◽  
The Absolute ◽  
Microscopic Techniques

The determination of the absolute polarity of a polar material is often crucial to the understanding of the defects which occur in such materials. Several methods exist by which this determination may be performed. In bulk, single-domain specimens, macroscopic techniques may be used, such as the different etching behavior, using the appropriate etchant, of surfaces with opposite polarity. X-ray measurements under conditions where Friedel’s law (which means that the intensity of reflections from planes of opposite polarity are indistinguishable) breaks down can also be used to determine the absolute polarity of bulk, single-domain specimens. On the microscopic scale, and particularly where antiphase boundaries (APBs), which separate regions of opposite polarity exist, electron microscopic techniques must be employed. Two techniques are commonly practised; the first [1], involves the dynamical interaction of hoLz lines which interfere constructively or destructively with the zero order reflection, depending on the crystal polarity. The crystal polarity can therefore be directly deduced from the relative intensity of these interactions.

516: A Simplified Method to Estimate the Absolute Renal Uptake of 99MTC-DMSA: Evaluation with a New Model using the Radioactivity of Nephrectomy Specimens as Reference

2005 ◽  
Vol 173 (4S) ◽  
pp. 140-141
Author(s):  
Mariana Lima ◽  
Celso D. Ramos ◽  
Sérgio Q. Brunetto ◽  
Marcelo Lopes de Lima ◽  
Carla R.M. Sansana ◽  
...  
Keyword(s):  
New Model ◽  
Renal Uptake ◽  
Simplified Method ◽  
The Absolute

Maternal DDAVP-induced hyponatremia: Threshold level for fetal urinary diuresis

1998 ◽  
Vol 5 (1) ◽  
pp. 151A-151A
Author(s):  
M NIJLAND ◽  
T ROBERTS ◽  
M CURRAN ◽  
M ROSS
Keyword(s):  
Threshold Level

Translocation Relative to Range

Methodology ◽  
2008 ◽  
Vol 4 (3) ◽  
pp. 132-138 ◽  
Author(s):  
Michael Höfler
Keyword(s):  
Risk Difference ◽  
Binary Outcomes ◽  
Number Needed To Treat ◽  
Likert Scales ◽  
Psychological Science ◽  
The Absolute ◽  
The Difference ◽  
Variance Parameters ◽  
Standardized Index ◽  
Maximum Possible Magnitude

A standardized index for effect intensity, the translocation relative to range (TRR), is discussed. TRR is defined as the difference between the expectations of an outcome under two conditions (the absolute increment) divided by the maximum possible amount for that difference. TRR measures the shift caused by a factor relative to the maximum possible magnitude of that shift. For binary outcomes, TRR simply equals the risk difference, also known as the inverse number needed to treat. TRR ranges from –1 to 1 but is – unlike a correlation coefficient – a measure for effect intensity, because it does not rely on variance parameters in a certain population as do effect size measures (e.g., correlations, Cohen’s d). However, the use of TRR is restricted on outcomes with fixed and meaningful endpoints given, for instance, for meaningful psychological questionnaires or Likert scales. The use of TRR vs. Cohen’s d is illustrated with three examples from Psychological Science 2006 (issues 5 through 8). It is argued that, whenever TRR applies, it should complement Cohen’s d to avoid the problems related to the latter. In any case, the absolute increment should complement d.

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