The mechanism of inhibition of anaerobic phosphate uptake by fatty acids in yeast

1972 ◽  
Vol 290 ◽  
pp. 348-354 ◽  
Author(s):  
G.W.F.H. Borst-Pauwels ◽  
J. Dobbelmann
Keyword(s):  
Fatty Acids ◽  
Phosphate Uptake ◽  
Mechanism Of Inhibition

A model study on the mechanism of inhibition of fatty acyl desaturases by cyclopropene fatty acids

Tetrahedron ◽  
1998 ◽  
Vol 54 (34) ◽  
pp. 10187-10198 ◽  
Author(s):  
Jordi Quintana ◽  
Mireia Barrot ◽  
Gemma Fabrias ◽  
Francisco Camps
Keyword(s):  
Fatty Acids ◽  
Fatty Acyl ◽  
Model Study ◽  
Mechanism Of Inhibition ◽  
Cyclopropene Fatty Acids

Studies on the mechanism of inhibition of nuclear triiodothyronine binding by fatty acids

FEBS Letters ◽  
1989 ◽  
Vol 246 (1-2) ◽  
pp. 6-12 ◽  
Author(s):  
F.R.M. van der Klis ◽  
W.M. Wiersinga ◽  
J.J.M. de Vijlder
Keyword(s):  
Fatty Acids ◽  
Mechanism Of Inhibition

To Remove Phosphate from Municipal Wastewater with Insufficient Volatile Fatty Acids

2011 ◽  
Vol 356-360 ◽  
pp. 1769-1772
Author(s):  
Gong Fa Chang ◽  
Feng Zhang ◽  
Chang Qing Liu ◽  
Bo Zhang ◽  
Xue Jun Bi
Keyword(s):  
Fatty Acids ◽  
Carbon Source ◽  
Volatile Fatty Acids ◽  
Municipal Wastewater ◽  
Phosphate Uptake ◽  
Plug Flow ◽  
Phosphate Concentration ◽  
Phosphate Removal ◽  
Flow Reactors ◽  
Phosphate Release

Tow plug flow reactors were operated with municipal wastewater according to reversed A2/O process. The only difference was in sludge return ratio. Despite that more VFAs were consumed by denitrification, phosphate removal was enhanced rather than impaired by a higher sludge return ratio of 300%. It seems that higher phosphate removal can be achieved even more nitrate was reduced which means more carbon source consumption. This is contradictory with the well accepted enhanced biological phosphate removal (EBPR) theory, which regards sufficient volatile fatty acids in the wastewater as the indispensable premise. With less phosphate was released in the anaerobic zones, the final phosphate concentration in the effluent was lower when higher sludge return ratio was applied. The results indicated that neither carbon source nor phosphate release can directly determine phosphate uptake ability.

Interactions between Phosphate, Nitrate and Organic Substrate in Biological Nutrient Removal Processes

1987 ◽  
Vol 19 (1-2) ◽  
pp. 183-194 ◽  
Author(s):  
A. Gerber ◽  
E. S. Mostert ◽  
C. T. Winter ◽  
R. H. de Villiers
Keyword(s):  
Fatty Acids ◽  
Nutrient Removal ◽  
Phosphate Uptake ◽  
Short Chain Fatty Acids ◽  
Organic Substrate ◽  
Short Chain ◽  
Biological Nutrient Removal ◽  
Phosphate Release ◽  
Removal Processes ◽  
Chain Fatty Acids

The response of activated sludge following exposure to various organic compounds is decribed. Batch systems simulating the various stages of biological nutrient removal processes were used to study the dependence of phosphate release, enhanced phosphate uptake and denitrification on the nature and level of organic substrate, and the presence or absence of nitrate. The phenomenon of phosphate release is shown to be controlled primarily by the nature of the substrate rather than the creation of an anaerobic state. Certain short-chain fatty acids or their salts, such as acetate and propionate, induce phosphate release even under anoxic or aerobic conditions but with compounds such as ethanol and glucose release occurs only after the onset of anaerobiosis. Given the necessary conditions, the time course of phosphate concentration in initially anoxic mixtures of phosphate-rich sludge and short-chain fatty acids is shown to proceed in three consecutive stages, comprising primary release, anoxic uptake and secondary release respectively. It is concluded that phosphate uptake and release occur simultaneously in the presence of fatty acids, which also render the best overall phosphate removal during aeration.

Competition between fatty acids and carbohydrate or ketone bodies as metabolic fuels for the isolated perfused heart

1987 ◽  
Vol 65 (3) ◽  
pp. 401-406 ◽  
Author(s):  
Robert G. P. Forsey ◽  
Kathy Reid ◽  
John T. Brosnan
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Pyruvate Dehydrogenase ◽  
Potent Inhibitor ◽  
Ketone Bodies ◽  
Pyruvate Dehydrogenase Kinase ◽  
Isolated Perfused Heart ◽  
Perfused Heart ◽  
Mechanism Of Inhibition ◽  
Site Of Action

The ability of carbohydrate fuels (lactate, pyruvate, glucose) and the ketone bodies (acetoacetate, β-hydroxybutyrate) to compete with fatty acids as fuels of respiration in the isolated Langendorf-perfused heart was studied. Oleate and octanoate were used as fatty acid fuels since oleate requires carnitine for entry into mitochondria, whereas octanoate does not. The two ketone bodies inhibited the oxidation of both oleate and octanoate implying an intramitochondrial site of action. Pyruvate, lactate, and lactate plus glucose inhibited oleate oxidation but not octanoate oxidation, indicating a mechanism of inhibition that involves the carnitine system. Pyruvate was a more potent inhibitor than lactate at equal concentrations, but the effect of lactate could be greatly increased by dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase. The physiological and mechanistic implications of these observations are discussed.

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