Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells

1991 ◽  
Vol 178 (3) ◽  
pp. 993-1001 ◽  
Author(s):  
Veronique Vandevoorde ◽  
Guy Haegeman ◽  
Walter Fiers
Keyword(s):  
Signal Transduction ◽  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
L929 Cells ◽  
Common Signal ◽  
Necrosis Factor

The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation

1994 ◽  
Vol 72 (11-12) ◽  
pp. 471-474 ◽  
Author(s):  
Richard N. Kolesnick ◽  
Adriana Haimovitz-Friedman ◽  
Zvi Fuks
Keyword(s):  
Tumor Necrosis Factor ◽  
Ionizing Radiation ◽  
Tumor Necrosis ◽  
Signal Transduction Pathway ◽  
Transduction Pathway ◽  
Signaling System ◽  
Common Pathway ◽  
Factor Α ◽  
Hydrolysis Of ◽  
Necrosis Factor

Recent evidence suggests that tumor necrosis factor α, Fas, and ionizing radiation employ the sphingomyelin pathway to trigger apoptosis. The sphingomyelin pathway is initiated by hydrolysis of plasma membrane sphingomyelin to generate ceramide via a sphingomyelinase. Ceramide serves as a second messenger stimulating a cascade of kinases and transcription factors that activate a final common pathway of programmed cell death. The extent to which this signaling system is used in apoptosis induced by other toxic modalities is not known, but accumulating evidence suggests that it is a commonly employed pathway that could be exploited therapeutically.Key words: sphingomyelin, apoptosis, tumor necrosis factor, Fas, ionizing radiation.

Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6

2000 ◽  
Vol 60 (8) ◽  
pp. 1185-1195 ◽  
Author(s):  
Wim Vanden Berghe ◽  
Linda Vermeulen ◽  
Gert De Wilde ◽  
Karolien De Bosscher ◽  
Elke Boone ◽  
...  
Keyword(s):  
Signal Transduction ◽  
Gene Regulation ◽  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Inflammatory Cytokine ◽  
Necrosis Factor
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