The prognostic significance of maternal serum CA125 measurement in threatened abortion

PURPOSE The aim of this study was to investigate the independent significance of prognostic factors in stage I invasive epithelial ovarian cancer (EOC). PATIENTS AND METHODS Between 1980 and 1994, all patients with stage I EOC (borderline tumors excluded) following surgical resection were entered onto this study. No patient received adjuvant therapy and patients were monitored as follows: years 1 to 2-physical examination and serum CA125 every 3 months and computed tomographic (CT) scan every 6 months; years 3 to 5-physical examination and serum CA125 every 6 months and CT scan yearly; years 5 to 10-annual physical examination and serum CA125, with CT scan if clinically indicated. RESULTS A total of 194 patients entered the study. The median patient age was 54 years (range, 15 to 83), and the median follow-up duration 54 months (range, 7 to 157). Five-year survival rates were as follows: stage IA, 93.7%; stage IB, 92%; and stage IC, 84%. Multivariate analysis using Cox's regression identified grade (P < .001), presence of ascites (P = .05), and surface tumor (P < .01) as independent poor prognostic factors. International Federation of Gynecology and Obstetrics (FIGO) substage did not appear to have independent prognostic significance. Intraoperative capsule rupture was not found to be prognostically significant. The impact of pre-operative rupture remains unclear. CONCLUSION This is an important series, as no patient received adjuvant therapy, and represents the natural history of surgically resected stage I EOC.

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Maternal serum inhibin A levels may predict pregnancy outcome in women with threatened abortion

Fertility and Sterility ◽

10.1016/j.fertnstert.2003.08.008 ◽

2004 ◽

Vol 81 (2) ◽

pp. 468-470 ◽

Cited By ~ 25

Author(s):

Pasquale Florio ◽

Stefano Luisi ◽

Donato D'Antona ◽

Filiberto M Severi ◽

Giuseppe Rago ◽

...

Keyword(s):

Pregnancy Outcome ◽

Maternal Serum ◽

Inhibin A ◽

Threatened Abortion

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The predictive value of serum cancer antigen 125 (CA125) levels on pregnancy outcome in threatened miscarriages

Journal of Perinatal Medicine ◽

10.1515/jpm-2019-0097 ◽

2019 ◽

Vol 47 (7) ◽

pp. 704-709

Author(s):

Mosunmola A. Adeku ◽

Omololu Adegbola ◽

Godwin O. Ajayi

Keyword(s):

Pregnancy Outcome ◽

Predictive Value ◽

Mean Value ◽

Maternal Serum ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Study Group ◽

Cancer Antigen 125 ◽

Serum Ca125 ◽

The Mean

Abstract Background Spontaneous miscarriages are common pregnancy complications which result in psychological and emotional burden in the affected women. It is therefore necessary to identify biomarkers that can predict pregnancy outcome in women with threatened miscarriages so as to assist in their counselling and management. Methods The study compared levels of maternal serum CA125 in 65 pregnancies with threatened miscarriages (study group) with 65 normal intrauterine pregnancies (control group) between 6 weeks and 19 weeks + 6 days gestation using an enzyme linked immunosorbent assay (ELISA) technique. Results The mean age of the study and control groups were 29.5 ± 0.14 years and 30.1 ± 0.14 years, respectively. The mean serum CA125 in the study group was 30.1 ± 1.1 IU/mL while that of the control group was 22.9 ± 1.2 IU/mL and this was statistically significant (P = 0.0001). The mean serum CA125 level in the women whose pregnancies were aborted (aborters) was 34.8 ± 1.4 IU/mL while the mean value among those whose pregnancies continued till term (non-aborters) was 27.3 ± 1.2 IU/mL. This was statistically significant (P = 0.001). Further analysis using CA125 ≥36.2 IU/mL (mean value of serum CA125 among aborters + 1 standard deviation) as a threshold for intrauterine pregnancies that eventually got aborted showed a sensitivity of 66.7%, specificity of 83.3%, positive predictive value of 55.6%, negative predictive value of 88.9% and the diagnostic effectiveness (accuracy) was 79.4%. Conclusion The measurement of serum CA125 is a useful predictor of pregnancy outcome in threatened miscarriages.

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The prognostic significance of serum CA125 levels with ER, PR, P53 and Ki-67 expression in endometrial carcinomas

Ginekologia Polska ◽

10.5603/gp.2019.0116 ◽

2019 ◽

Vol 90 (12) ◽

pp. 675-683

Author(s):

Emine Budak ◽

Dudu Solakoglu Kahraman ◽

Adnan Budak ◽

Ahmet Yanarateş ◽

Abdurrahman Hamdi Inan ◽

...

Keyword(s):

Prognostic Significance ◽

Ki 67 ◽

Serum Ca125 ◽

Endometrial Carcinomas

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Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma

Oncotarget ◽

10.18632/oncotarget.8770 ◽

2016 ◽

Vol 7 (23) ◽

pp. 35423-35436 ◽

Cited By ~ 14

Author(s):

Wei Wang ◽

Xiao-Long Chen ◽

Shen-Yu Zhao ◽

Yu-Hui Xu ◽

Wei-Han Zhang ◽

...

Keyword(s):

Gastric Carcinoma ◽

Prognostic Significance ◽

Preoperative Serum ◽

Serum Ca125

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THE EVALUATION OF CORD-BLOOD HEMOGLOBIN, RETICULOCYTE PERCENTAGE AND MATERNAL ANTIGLOBULIN TITER IN THE PROGNOSIS OF HEMOLYTIC DISEASE OF THE NEWBORN (ERYTHROBLASTOSIS FETALIS)

PEDIATRICS ◽

10.1542/peds.20.2.221 ◽

1957 ◽

Vol 20 (2) ◽

pp. 221-233

Author(s):

G. A. Kelsall ◽

G. H. Vos ◽

R. L. Kirk ◽

J. W. Shield

Keyword(s):

Cord Blood ◽

Antibody Titer ◽

Prognostic Significance ◽

Prognostic Index ◽

Maternal Serum ◽

Maternal Antibody ◽

Distinct Advantage ◽

Plasma Albumin ◽

Clear Cut ◽

Blood Hemoglobin

An unselected series of 218 consecutive pregnant women in whom Rh antibodies were detected by means of a standardized antiglobulin test has been studied to evaluate the prognostic significance of values for cord-blood hemoglobin, reticulocyte percentage and maternal antibody titer at term. Twenty-four of the women gave birth to Rh-negative infants, 35 to stillborn infants, the majority of whom were severely macerated, and 159 to liveborn Rh-positive infants. All but three of the Rh-positive liveborn infants who were not moribund at birth were exchange-transfused if the maternal titer at term was 1:128 or higher. Of the 159 Rh-positive liveborn infants, 19 subsequently died, 5 of these being in the untreated group. The remainder were alive and well at least 1 month after birth. The antibody titer of the maternal serum at term determined by the indirect antiglobulin technique is not quite such a good prognostic index of the chance of survival of liveborn Rh-positive infants as either values for cord-blood hemoglobin or reticulocyte percentage. Titration values of the maternal serum have the distinct advantage that they can be determined before birth, and so give guidance in the management of the case, including the early induction of labor. A statistical comparison of the effectiveness of treatment showed that the lower neonatal death rate achieved in the present series was not significantly different from that in comparable series in England and America. Comparison with results published for a comparable American series, where the prognostic significance of maternal antibody titer at term as determined by the plasma-albumin method was evaluated, suggests that the indirect antiglobulin technique for titrating the antibodies in the maternal serum is not only more sensitive than the plasma-albumin method, but it achieves a more clear-cut separation between mild and severe cases. In consequence the indirect antiglobulin technique gives titration values of greater prognostic significance. Once the child is born, prognosis based on a combination of either maternal antibody titer with values for cord-blood hemoglobin or reticulocyte percentage is more accurate than one based on maternal antibody titer alone.

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