Effects of the type of dietary fat at two levels of vitamin E in wistar male rats during development and aging

1980 ◽  
Vol 13 (1) ◽  
pp. 1-39 ◽  
Author(s):  
Eduardo A. Porta ◽  
Nam S. Joun ◽  
Ronald T. Nitta
2019 ◽  
Vol 56 (2) ◽  
pp. 337-340
Author(s):  
Daniela Miricescu ◽  
Daniela Gabriela Balan ◽  
Catalina Radulescu ◽  
Radu Radulescu ◽  
Iulia-Ioana Stanescu ◽  
...  

PLGA (Poli-lactic-co-glycolic acid) nanoparticles (NPs) are curently used as drug delivery systems for many types of drugs including antioxidants such as vitamin E. The main aim of our study was to test the antioxidant effects of PLGA-vitamin E on Wistar male rats. Two groups of Wistar rats received a hypercaloric diet for 21 days: the first group received besides the hypercaloric diet a daily dose of PLGA loaded with vitamin E and the control group received only the hypercaloric diet. Spleen cellular lysate has been used to detect biomarkers of oxidative stress such as malondialdehyde, glutathione, advanced human oxidative protein and vitamin E. After 3 weeks of treatment, statistical significant changes have been detected between the two groups.


1983 ◽  
Vol 24 (2) ◽  
pp. 135-147 ◽  
Author(s):  
P. Thode Jensen ◽  
H. E. Nielsen ◽  
V. Danielsen ◽  
T. Leth

2010 ◽  
Vol 29 (3) ◽  
pp. 313-317
Author(s):  
Waleed A. Al-Madani ◽  
Nikhat J. Siddiqi ◽  
Abdullah S. Alhomida ◽  
Haseeb A. Khan ◽  
Ibrahim A. Arif ◽  
...  

This investigation was aimed to study the effect of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on mercuric chloride (HgCl2)-induced alterations in urinary excretion of various carnitine fractions including free carnitine (FC), acylcarnitine (AC), and total carnitine (TC). Different groups of Wistar male rats were treated with HgCl2 at the doses of 0.1, 0.5, 1.0, 2.0, and 3.0 mg/kg body weight, and the animals were sacrificed at 24 hours following HgCl2 injection. A separate batch of animals received HgCl2 (2 mg/kg) with or without DMPS (100 mg/kg) and sacrificed at 24 or 48 hours after dosing. Administration of HgCl2 resulted in statistically significant and dose-dependent increase in the urinary excretion of FC, AC, and TC in rats. However, the ratio of urinary AC:FC was significantly decreased by HgCl2. Pretreatment with DMPS offered statistically significant protection against HgCl2-induced alterations in various urinary carnitine fractions in rats.


2003 ◽  
Vol 111 (3) ◽  
pp. 215-216
Author(s):  
G. Metin ◽  
M.K. Gümüstas ◽  
A. Belce ◽  
A. Kayserilioglu

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