4.20 T+ cell number increase in the spleen of chicken embryos in GVH-R serial transfer experiments

1989 ◽  
Vol 13 (4) ◽  
pp. 392
Author(s):  
B. Fedecka-Bruner ◽  
J. Desveaux-Chabrol ◽  
F. Dieterlen-Liévre
Keyword(s):  
T Cell ◽  
Cell Number ◽  
Serial Transfer ◽  
Chicken Embryos ◽  
Number Increase

Improving Biomaterials from a Cellular Point of View

2006 ◽  
Vol 925 ◽  
Author(s):  
Venu Gopal Varanasi ◽  
T. Vallortigara ◽  
P. M. Loomer ◽  
E. Saiz ◽  
A. P. Tomsia ◽  
...  
Keyword(s):  
Dissolution Rate ◽  
Cell Number ◽  
Point Of View ◽  
Dissolution Behavior ◽  
Ti Alloy ◽  
Bioactive Glasses ◽  
Culture Studies ◽  
Cell Numbers ◽  
Number Increase

ABSTRACTBioactive glasses (6P55) used for coating Ti/Ti-alloy were tested for their in vitro behavior in a comparative study with commercial Bioglass™ (45S5) and commercial Ti alloy (Ti6Al4V). In vitro testing included pH and dissolution rate determination in simulated body fluid (SBF) along with in vitro cyto compatibility testing. It was seen in this work that 6P55 and 45S5 had similar dissolution behavior, demonstrating t½ dependence and maximum pH of approximately 8.1 after 10 days of immersion. This pH was reduce by 0.2 0.4 pH units when the in vitro V:A ratio was increased from 1 to 3. The dissolution rate of these glasses approached 0 after additional immersion tests after 15 days and the pH stablilized at less than 7.5. Cell culture studies showed that both glasses behaved in similar fashion after 16 hours in culture. Both glasses had an increase in cell numbers of close to 200-250%, whereas Ti6Al4V had a less pronounced cell number increase (∼ 180%)

scholarly journals Clinical and immunological features in a cohort of patients with partial DiGeorge syndrome followed at a single center

Blood ◽  
2019 ◽  
Vol 133 (24) ◽  
pp. 2586-2596 ◽  
Author(s):  
Giuliana Giardino ◽  
Nesrine Radwan ◽  
Patra Koletsi ◽  
Deborah M. Morrogh ◽  
Stuart Adams ◽  
...  
Keyword(s):  
Risk Factor ◽  
T Cell ◽  
T Lymphocytes ◽  
Digeorge Syndrome ◽  
Cell Number ◽  
Physiological Age ◽  
Upper Respiratory Tract ◽  
Street Hospital ◽  
Age Related ◽  
Tract Infections

Abstract DiGeorge syndrome (DGS) is a primary immunodeficiency characterized by various degrees of T-cell deficiency. In partial DGS (pDGS), other risk factors could predispose to recurrent infections, autoimmunity, and allergy. The aim of this study was to assess the effect of different factors in the development of infections, autoimmunity, and/or allergy in patients with pDGS. We studied 467 pDGS patients in follow-up at Great Ormond Street Hospital. Using a multivariate approach, we observed that palatal anomalies represent a risk factor for the development of recurrent otitis media with effusion. Gastroesophageal reflux/dysphagia and asthma/rhinitis represent a risk factor for the development of recurrent upper respiratory tract infections. Allergy and autoimmunity were associated with persistently low immunoglobulin M levels and lymphopenia, respectively. Patients with autoimmunity showed lower levels of CD3+, CD3+CD4+, and naïve CD4+CD45RA+CD27+ T lymphocytes compared with pDGS patients without autoimmunity. We also observed that the physiological age-related decline of the T-cell number was slower in pDGS patients compared with age-matched controls. The age-related recovery of the T-cell number depended on a homeostatic peripheral proliferation of T cells, as suggested by an accelerated decline of the naïve T lymphocytes in pDGS as well as a more skewed T-cell repertoire in older pDGS patients. These evidences suggest that premature CD4+ T-cell aging and lymphopenia induced spontaneous peripheral T-cell proliferation might contribute to the pathogenesis of autoimmunity in patients with pDGS. Infections in these patients represent, in most of the cases, a complication of anatomical or gastroenterological anomalies rather than a feature of the underlying immunodeficiency.

High stromal Foxp3-positive T cell number combined to tumor stage improved prognosis in head and neck squamous cell carcinoma

Oral Oncology ◽  
2017 ◽  
Vol 67 ◽  
pp. 183-191 ◽  
Author(s):  
Nadège Kindt ◽  
Géraldine Descamps ◽  
Imelda Seminerio ◽  
Justine Bellier ◽  
Jérôme R. Lechien ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cell ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tumor Stage ◽  
Cell Number ◽  
Neck Squamous Cell Carcinoma

T-Cell Number, Nutritional Status, and HIV

2015 ◽  
pp. 367-387
Author(s):  
Elisa Maritza Linares Guerra ◽  
Sergio Santana Porbén
Keyword(s):  
T Cell ◽  
Nutritional Status ◽  
Cell Number

Diet-induced adipocyte number increase in adult rats: a new model of obesity.

1978 ◽  
Vol 235 (3) ◽  
pp. E279 ◽  
Author(s):  
I M Faust ◽  
P R Johnson ◽  
J S Stern ◽  
J Hirsch
Keyword(s):  
Adipose Tissue ◽  
Weight Gain ◽  
Cell Number ◽  
Chow Diet ◽  
Adipocyte Size ◽  
Adult Rats ◽  
Tissue Morphology ◽  
Number Increase ◽  
Dietary Obesity ◽  
Morphology Changes

Adult rats of various strains became obese when they were fed a highly palatable diet for several months. Analysis of their adipose tissue morphology revealed increases in both adipocyte size and number in most depots. Reintroduction of an ordinary chow diet to such animals precipitated a period of weight loss during which only mean adipocyte size returned to normal. Adipocyte number remained at the elevated level achieved during the period of weight gain. Thus, transient dietary obesity in rats results in a persistent obesity of a purely hyperplastic, nonhypertrophic form. Furthermore, the persistence of the cell number increase suggests that it is the result of proliferation or differentiation rather than of only an increase in the lipid content of a pool of very small and normally undetected adipocytes. An analysis of adipose tissue morphology changes during the course of diet-induced weight gain suggests that the achievement of some specific mean adipocyte size triggers the events that culminate in adipocyte number increase. What mechanisms may link adipocyte size to the formation of new adipocytes remains unknown.

Effects of the ablation of the left cerebral cortex on T-cell number and cell-medaited responses in the mouse

1980 ◽  
Vol 2 (3) ◽  
pp. 156 ◽  
Author(s):  
G. Renoux ◽  
K. Bizière ◽  
M. Renoux ◽  
L. Gyenes ◽  
D. Degenne ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
T Cell ◽  
Cell Number

Relationship of CD8+ T cell noncytotoxic anti-HIV response to CD4+ T cell number in untreated asymptomatic HIV-infected individuals

Blood ◽  
2002 ◽  
Vol 99 (11) ◽  
pp. 4225-4227 ◽  
Author(s):  
JoAnn C. Castelli ◽  
Steven G. Deeks ◽  
Stephen Shiboski ◽  
Jay A. Levy
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Cell Number ◽  
Current Recommendation ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Cd8 Cell ◽  
Asymptomatic Individuals ◽  
Relationship Of ◽  
Cd4 Cell

During chronic HIV infection, asymptomatic individuals demonstrate a strong CD8+ cell noncytotoxic antiviral response (CNAR). With the onset of symptoms or reduction in CD4+ cell counts, CNAR decreases. Presently, it is recommended that infected individuals receive antiretroviral therapy if CD4+ cell counts fall below 350 cells/μL. To determine whether CNAR lends support to this recommendation for initiation of antiretroviral treatment, we examined CNAR in 20 healthy, untreated, HIV-infected men exhibiting a range of CD4+ cell numbers. Our results indicate that the asymptomatic untreated HIV-infected individuals with less than 300 CD4+ cells/μL had a significantly lower CNAR than those with higher CD4+ cell counts. These data on CNAR in untreated, healthy, HIV-infected individuals support the current recommendation for when to initiate antiretroviral therapy.

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