Effects of the ablation of the left cerebral cortex on T-cell number and cell-medaited responses in the mouse

Abstract DiGeorge syndrome (DGS) is a primary immunodeficiency characterized by various degrees of T-cell deficiency. In partial DGS (pDGS), other risk factors could predispose to recurrent infections, autoimmunity, and allergy. The aim of this study was to assess the effect of different factors in the development of infections, autoimmunity, and/or allergy in patients with pDGS. We studied 467 pDGS patients in follow-up at Great Ormond Street Hospital. Using a multivariate approach, we observed that palatal anomalies represent a risk factor for the development of recurrent otitis media with effusion. Gastroesophageal reflux/dysphagia and asthma/rhinitis represent a risk factor for the development of recurrent upper respiratory tract infections. Allergy and autoimmunity were associated with persistently low immunoglobulin M levels and lymphopenia, respectively. Patients with autoimmunity showed lower levels of CD3+, CD3+CD4+, and naïve CD4+CD45RA+CD27+ T lymphocytes compared with pDGS patients without autoimmunity. We also observed that the physiological age-related decline of the T-cell number was slower in pDGS patients compared with age-matched controls. The age-related recovery of the T-cell number depended on a homeostatic peripheral proliferation of T cells, as suggested by an accelerated decline of the naïve T lymphocytes in pDGS as well as a more skewed T-cell repertoire in older pDGS patients. These evidences suggest that premature CD4+ T-cell aging and lymphopenia induced spontaneous peripheral T-cell proliferation might contribute to the pathogenesis of autoimmunity in patients with pDGS. Infections in these patients represent, in most of the cases, a complication of anatomical or gastroenterological anomalies rather than a feature of the underlying immunodeficiency.

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4.20 T+ cell number increase in the spleen of chicken embryos in GVH-R serial transfer experiments

Developmental & Comparative Immunology ◽

10.1016/0145-305x(89)90110-9 ◽

1989 ◽

Vol 13 (4) ◽

pp. 392

Author(s):

B. Fedecka-Bruner ◽

J. Desveaux-Chabrol ◽

F. Dieterlen-Liévre

Keyword(s):

T Cell ◽

Cell Number ◽

Serial Transfer ◽

Chicken Embryos ◽

Number Increase

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High stromal Foxp3-positive T cell number combined to tumor stage improved prognosis in head and neck squamous cell carcinoma

Oral Oncology ◽

10.1016/j.oraloncology.2017.02.023 ◽

2017 ◽

Vol 67 ◽

pp. 183-191 ◽

Cited By ~ 9

Author(s):

Nadège Kindt ◽

Géraldine Descamps ◽

Imelda Seminerio ◽

Justine Bellier ◽

Jérôme R. Lechien ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

T Cell ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Tumor Stage ◽

Cell Number ◽

Neck Squamous Cell Carcinoma

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T-Cell Number, Nutritional Status, and HIV

Health of HIV Infected People ◽

10.1016/b978-0-12-800767-9.00021-2 ◽

2015 ◽

pp. 367-387

Author(s):

Elisa Maritza Linares Guerra ◽

Sergio Santana Porbén

Keyword(s):

T Cell ◽

Nutritional Status ◽

Cell Number

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Relationship of CD8+ T cell noncytotoxic anti-HIV response to CD4+ T cell number in untreated asymptomatic HIV-infected individuals

Blood ◽

10.1182/blood-2001-11-0078 ◽

2002 ◽

Vol 99 (11) ◽

pp. 4225-4227 ◽

Cited By ~ 28

Author(s):

JoAnn C. Castelli ◽

Steven G. Deeks ◽

Stephen Shiboski ◽

Jay A. Levy

Keyword(s):

T Cell ◽

Antiretroviral Therapy ◽

Cell Number ◽

Current Recommendation ◽

Cell Counts ◽

Cd4 Cell Counts ◽

Cd8 Cell ◽

Asymptomatic Individuals ◽

Relationship Of ◽

Cd4 Cell

During chronic HIV infection, asymptomatic individuals demonstrate a strong CD8+ cell noncytotoxic antiviral response (CNAR). With the onset of symptoms or reduction in CD4+ cell counts, CNAR decreases. Presently, it is recommended that infected individuals receive antiretroviral therapy if CD4+ cell counts fall below 350 cells/μL. To determine whether CNAR lends support to this recommendation for initiation of antiretroviral treatment, we examined CNAR in 20 healthy, untreated, HIV-infected men exhibiting a range of CD4+ cell numbers. Our results indicate that the asymptomatic untreated HIV-infected individuals with less than 300 CD4+ cells/μL had a significantly lower CNAR than those with higher CD4+ cell counts. These data on CNAR in untreated, healthy, HIV-infected individuals support the current recommendation for when to initiate antiretroviral therapy.

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Significant Expansion of Myeloid Derived Suppressor Cells in Patients with High- Risk Breast Cancer Treated with Dose Dense Adjuvant Chemotherapy

Blood ◽

10.1182/blood.v112.11.4653.4653 ◽

2008 ◽

Vol 112 (11) ◽

pp. 4653-4653

Author(s):

James E Talmadge ◽

Elizabeth Reed ◽

Kenneth Cowan ◽

Dmitry Gabrilovich ◽

Phyllis Warkentin ◽

...

Keyword(s):

T Cell ◽

Cancer Patients ◽

Mononuclear Cells ◽

Flow Analysis ◽

Suppressor Cells ◽

Cell Number ◽

Myeloid Derived Suppressor Cells ◽

Breast Cancers ◽

Dose Dense ◽

And Function

Abstract Myeloid derived suppressor cells (MDSCs) have been reported to be expanded in cancer patients, following growth factor administration and after chemotherapy. These cells have been associated with a loss of T-cell number and function and provide one mechanism of immune evasion. We examined the effect of dose dense chemotherapy on immune phenotypes and function in patients with breast cancers 4 cms or larger and/or four or more involved nodes. The adjuvant therapy was dose-dense doxorubicin, cyclophosphamide (AC) followed by paclitaxel (P), then 33 doses of radiation (R). Blood samples were obtained and studied prior to therapy, 1 week post AC and 1, 15 and 21 weeks post P and then 3, 6 and 12 months later. Flow cytometric analyses of cellular phenotypes were done on these blood specimens and compared to the levels prior to therapeutic intervention and to normal age and sex matched donors. Twenty-three pts have been followed a median of 29 months (range 5.5–50.5 months) from study entry. Two patients relapsed 8 and 23 months after diagnosis. T-cell CD-4 numbers declined following AC from an average of 4.9±0.5 ×106/ml to 1.7±0.3×106/ml, but increased to an average of 2.7± 0.3 × 106/ml, 21 weeks after P or 12 weeks after R. In this study the MDSCs were defined as Lin- (CD3, CD19, CD14 and CD13), HLA-DR- and CD33+. The numbers of MDSCs, which in normal donors were 0.62±0.16×106/ml and in the cancer patients at diagnosis were 11.8±9.6×106/ml increased to 58.4±25.9×106/ml 15 weeks after R. They remained significantly elevated through one year after diagnosis when they were 27.3±12.3×106/ml. The majority of the MDSCs had a high side scatter and forward scatter by flow analysis suggesting a granulocytic commitment rather than a monocytic commitment. The increase in MDSC numbers was apparently associated with R as the numbers of MDSCs were not significantly increased by AC (15.7±13.5×106/ml) or P (10.9±6×106/ml) one week following completion of each cycle of dose dense therapy. In association with the increase in MDSCs there was a significant decrease in PHA proliferation by the peripherial blood mononuclear cells (MNCs) and suppressive activity by irradiated MNC for allergenic lymphocytes.

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