Effects of calcium and vitamin D supplementation in the elderly on discontinuous exteral nutrition (DEN)

1991 ◽  
Vol 10 ◽  
pp. 54
Author(s):  
M.O. Besnier ◽  
J.P. Gardin ◽  
C. Melin
Keyword(s):  
Vitamin D ◽  
The Elderly ◽  
Vitamin D Supplementation

Prevalence of 25-hydroxyvitamin D deficiency in subgroups of elderly persons with anemia: association with anemia of inflammation

Blood ◽  
2011 ◽  
Vol 117 (10) ◽  
pp. 2800-2806 ◽  
Author(s):  
Todd S. Perlstein ◽  
Reena Pande ◽  
Nancy Berliner ◽  
Gary J. Vanasse
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
World Health ◽  
Elderly Persons ◽  
Increased Risk ◽  
Health Organization ◽  
Anemia Of Inflammation

AbstractAnemia and vitamin D deficiency are conditions that both result in significant morbidity and increase with age. The potential relationship between them remains poorly understood, particularly in the elderly. We used the Third National Health and Nutrition Examination Survey to examine the association of vitamin D deficiency with anemia subtypes in persons aged ≥ 60 years. Vitamin D deficiency was defined as serum levels < 20 ng/mL, and anemia was defined according to World Health Organization criteria. Vitamin D deficiency was associated with anemia prevalence independent of age, sex, or race/ethnicity (odds ratio, 1.47; 95% confidence interval, 1.06-2.05; P = .02) and varied significantly by anemia subtype (P overall = .003). The prevalence of vitamin D deficiency was 33.3% in the nonanemic population, 56% in anemia of inflammation (AI; P = .008), and 33.0% in unexplained anemia (P = .55). Non-Hispanic blacks had a 7-fold increased risk of AI compared with whites, and this was partially attenuated after adjusting for vitamin D deficiency. These data show that vitamin D deficiency is associated with specific subtypes of anemia in the elderly, especially in those with AI. Vitamin D may suppress inflammatory pathways, and studies to determine whether vitamin D supplementation ameliorates AI are warranted.

scholarly journals Effects of vitamin D supplementation on 25(OH)D levels and blood pressure in the elderly: a systematic review and meta-analysis

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 633
Author(s):  
Farapti Farapti ◽  
Chusnul Fadilla ◽  
Niwanda Yogiswara ◽  
Merryana Adriani
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Meta Analysis ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Control Groups ◽  
Elderly Age ◽  
Hydroxyvitamin D ◽  
And Control

Background: Hypertension and vitamin D deficiency are prevalent among the elderly. This study evaluated the effects of vitamin D supplementation on changes in serum 25-hydroxyvitamin D (25(OH)D) levels and blood pressure (BP) in the elderly (age > 60 years). Methods: Randomized controlled trials from electronic databases on the elderly taking oral vitamin D, until the end of March 2019, were selected. Two reviewers independently screened the literature on the basis of specific inclusion criteria. The primary outcomes were serum 25(OH)D level, systolic BP (SBP), and diastolic BP (DBP) changes. Results: Our analysis revealed significant differences in serum 25(OH)D level changes between the vitamin D and control groups (mean difference [MD] = 13.84; 95% confidence interval [CI] = 10.21–17.47; P < 0.000). There were no significant differences in SBP and DBP changes between the vitamin D and control groups. Subgroup analysis revealed significant differences in SBP changes between the hypertensive and vitamin D-deficient subgroups (MD = –4.01; 95% CI = –7.45 to –0.57; P = 0.02 and MD = –1.91; 95% CI = –3.48 to –0.34; P = 0.02, respectively), and DBP changes only in the hypertensive subgroup (MD = –2.22; 95% CI = –4.1 to –0.34; P = 0.02). Conclusions: Vitamin D supplementation significantly increases 25(OH)D levels and seems beneficial in lowering BP, specifically in the elderly with elevated BP and vitamin D deficiency.

scholarly journals A cost analysis of systematic vitamin D supplementation in the elderly versus supplementation based on assessed requirements

2017 ◽  
Vol 2 (2) ◽  
pp. 13-22
Author(s):  
Lisa Ericson  ◽  
Bo Hovstadius ◽  
Martin Carlsson  ◽  
Göran Petersson  ◽  
Pär Wanby 
Keyword(s):  
Vitamin D ◽  
Cost Analysis ◽  
The Elderly ◽  
Vitamin D Supplementation

scholarly journals Potential Role of Vitamin D in the Elderly to Resist COVID-19 and to Slow Progression of Parkinson’s Disease

2020 ◽  
Vol 10 (5) ◽  
pp. 284 ◽  
Author(s):  
Casey A. Hribar ◽  
Peter H. Cobbold ◽  
Frank C. Church
Keyword(s):  
Older Adults ◽  
Parkinson’S Disease ◽  
Vitamin D ◽  
Parkinson's Disease ◽  
Vitamin D3 ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Older Individuals ◽  
Related Quality ◽  
Cholecalciferol Supplementation

While we are still learning more about COVID-19, caused by the novel SARS-CoV-2 virus, finding alternative and already available methods to reduce the risk and severity of the disease is paramount. One such option is vitamin D, in the form of vitamin D3 (cholecalciferol) supplementation, due to its potential antiviral properties. It has become apparent that older individuals have a greater risk of developing severe COVID-19, and compared to younger adults, the elderly have lower levels of vitamin D due to a variety of biological and behavioral factors. Older adults are also more likely to be diagnosed with Parkinson’s disease (PD), with advanced age being the single greatest risk factor. In addition to its immune-system-modulating effects, it has been suggested that vitamin D supplementation plays a role in slowing PD progression and improving PD-related quality of life. We completed a review of the literature to determine the relationship between vitamin D, PD, and COVID-19. We concluded that the daily supplementation of 2000–5000 IU/day of vitamin D3 in older adults with PD has the potential to slow the progression of PD while also potentially offering additional protection against COVID-19.

Substantiation for vitamin D supplementation in the elderly

2020 ◽  
pp. 13-20
Author(s):  
Natalya Mamylina
Keyword(s):  
Vitamin D ◽  
Peripheral Blood ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Neutrophil Granulocytes ◽  
Blood Neutrophil ◽  
Peripheral Blood Neutrophil ◽  
Cytokine Balance ◽  
Sf 36

Role of vitamin D in the formation of pathogenic changes related to factors of innate immunity and cytokine status has been studied in 105 non-working women aged 61.0±1.25 years. Prior to the study, the quality of life has been determined using the SF-36 questionnaire, as well as decrease in total vitamin D content, violation of functional and metabolic status of peripheral blood neutrophil granulocytes, imbalance in subpopulation of lymphocytes, and production of Th1/Th2 cytokines have been revealed. Presence of direct correlation between the qualitative composition and oxygen-dependent metabolism of peripheral blood neutrophil granulocytes, vitamin D content, and cytokine balance has been proved. Vitamin D supplementation in a daily dose of 1000 reduced the severity of immune disorders in the patients, which confirms the need for vitamin D supplementation in the elderly with a vitamin D deficiency confirmed by laboratory tests.

scholarly journals (Preventing) two birds with one stone: improving vitamin D levels in the elderly

2011 ◽  
Vol 3 (2) ◽  
pp. 150 ◽  
Author(s):  
Susie Lawless ◽  
Phil White ◽  
Prue Murdoch ◽  
Sharon Leitch
Keyword(s):  
Vitamin D ◽  
Vaccination Campaign ◽  
Fragility Fractures ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Adverse Outcomes ◽  
Flu Vaccination ◽  
Increased Risk ◽  
Vitamin D Levels

BACKGROUND AND CONTEXT: A majority of adults have sub-optimal vitamin D levels in the winter in southern New Zealand. This is associated with an increased risk of falls and fragility fractures in the elderly, with long-term adverse outcomes likely. Vitamin D supplementation decreases the risks of both falls and fractures. ASSESSMENT OF PROBLEM: An intervention was undertaken by a small urban general practice to increase the number of elderly patients receiving vitamin D supplementation by linking vitamin D prescription to the annual flu vaccination campaign. RESULTS: Uptake of the supplementation was high and costs to the practice low. Thirty-eight patients were identified for whom long-term supplementation with vitamin D was indicated. STRATEGIES FOR IMPROVEMENT: The study could have been strengthened by incorporating a more formal method of evaluating uptake. LESSONS: Encouraging patients to take supplements as a population-based strategy is a realistic intervention, and linking it to the flu vaccination campaign is both seasonally appropriate and efficient. KEYWORDS: Vitamin D deficiency; elderly; vitamin D supplementation; cholecalciferol; prevention; fragility fractures; intervention

scholarly journals VITAMIN D SUPPLEMENTATION AND FUNCTIONAL KNEE OSTEOARTHRITIS PROGRESSION IN OLDER ADULTS WITH OBESITY: DATA FROM THE OSTEOARTHRITIS INITIATIVE

2015 ◽  
pp. 1-4
Author(s):  
A.J. Zbehlik ◽  
L.K. Barre ◽  
J.A. Batsis ◽  
E.A. Scherer ◽  
S.J. Bartels
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Knee Osteoarthritis ◽  
The Elderly ◽  
Pain Scale ◽  
Primary Outcome Measure ◽  
Vitamin D Supplementation ◽  
Womac Pain ◽  
Increased Risk ◽  
Osteoarthritis Initiative

Objective: Older adults with obesity are at increased risk of knee osteoarthritis (KOA) and vitamin D deficiency, but data on the effect of vitamin D supplementation in this population are equivocal. This study evaluated the effect of vitamin D supplementation on functional progression of KOA in older adults with obesity. Participants with Body Mass Index ≥30 kg/m2 and aged ≥ 60 years from the Osteoarthritis Initiative progression cohort were stratified by baseline vitamin D use. The relationship between vitamin D supplementation and progression of KOA at 72 months was characterized. The Western Ontario McMaster University Osteoarthritis Index (WOMAC) pain scale was the primary outcome measure. Secondary measures included: WOMAC disability, Physical Activity Scale for the Elderly, gait speed and Knee injury and Osteoarthritis Outcome Score (KOOS) scales. In older adults with KOA and obesity, baseline supplemental vitamin D use did not predict functional progression of osteoarthritis at 72 months.

scholarly journals Efficacy and safety of calcium and vitamin D supplementation to prevent osteoporotic fracture

2021 ◽  
Vol 64 (4) ◽  
pp. 305-312
Author(s):  
Bom Taeck Kim
Keyword(s):  
Vitamin D ◽  
Clinical Trials ◽  
Osteoporotic Fracture ◽  
Osteoporotic Fractures ◽  
Fragility Fractures ◽  
The Elderly ◽  
Vitamin D Supplementation ◽  
Efficacy And Safety ◽  
Vitamin D Supplement ◽  
Fatal Myocardial Infarction

Dietary supplementation of calcium and vitamin D has been deemed one of the most important tools to fight against osteoporotic fractures increasing with aging of the population globally. Reports from early clinical trials demonstrated that supplementation of calcium and vitamin D for patients with osteoporosis can reduce the incidence of fragility fractures by decreasing bone loss and falls. However, following trials failed to demonstrate the efficacy of calcium and vitamin D for the prevention of osteoporotic fractures, questioning the need of calcium and vitamin D supplementation. Even metanalyses and system reviews presented opposite conclusions , depending on clinical trials included. Recent studies reported that excessive calcium supplement can increase cardiovascular risk such as non-fatal myocardial infarction and that excessive vitamin D supplement can produce more frequent falls than it is supposed to be. However, in spite of some arguments regarding the efficacy and safety of calcium and vitamin D supplementation, it seems to be essential to provide 800 to 1,000 mg elementary calcium and 800 to 1,000 IU vitamin D for the elderly whose intake of calcium and vitamin D is insufficient to prevent osteoporotic fracture.

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