On-line radiotherapy imaging. i: refinement of a fiber-optic imaging system for clinical applications

Author(s):  
J.W. Wong ◽  
W.R. Binns ◽  
A.Y. Chengl ◽  
L.Y. Geer ◽  
J.W. Epstein ◽  
...  
1991 ◽  
Vol 21 (5) ◽  
pp. 1327-1336 ◽  
Author(s):  
Karen J. Halverson ◽  
T.C. Leung ◽  
Jonathan B. Pellet ◽  
Russ L. Gerber ◽  
Martin S. Weinhous ◽  
...  

1991 ◽  
Vol 20 (3) ◽  
pp. 613-619 ◽  
Author(s):  
Mary Lee Graham ◽  
Abel Y. Cheng ◽  
Lewis Y. Geer ◽  
W.Robert Binns ◽  
Michael W. Vannier ◽  
...  

2018 ◽  
Vol 14 (4) ◽  
pp. 267-270
Author(s):  
Tian-xiang Zheng ◽  
Guang-yue Shen ◽  
Zhao-hui Li ◽  
E. Wu ◽  
Xiu-liang Chen ◽  
...  

1997 ◽  
Vol 3 (S2) ◽  
pp. 845-846
Author(s):  
S. Michael Angel ◽  
H. Trey Skinner ◽  
Brian J. Marquardt

Optical fiber probes are routinely used with optical spectrometers to allow measurements to be made on remotely located samples. In most of these systems, however, the optical fibers are used as non-imaging “light pipes” for the transmission of laser light, and luminescence or Raman signals to and from the sample. Thus, while these systems are suitable for remote spectroscopy, they are limited to single-point measurements. In a recent paper, we showed that a small-diameter (i.e., 350 μm) coherent optical fiber bundle can be combined with an AOTF-based imaging spectrometer for fluorescence and Raman spectral micro-imaging with increased flexibility in terms of sample positioning and in-situ capabilities. The previous paper described the operation of the fiber-optic microimaging probe and AOTF imaging system and showed preliminary Raman and fluorescence images for model compounds with 4 μm resolution. We have extended this work to include a discussion of the lateral and vertical spatial resolution of the fiber-optic microprobe in a non-contact proximity-focused configuration.


1997 ◽  
Vol 503 ◽  
Author(s):  
Edward G. Nawy ◽  
P. E.

ABSTRACTThis investigation involves the identification and use of a novel type of fiber optic sensors in monitoring the deformation behavior of critical sections of the structural concrete elements and transforming them into smart systems. Basic operating principles of the Bragg-grating sensors identified in this work are proved to be feasible. Deformational behavior was studied of high performance concrete composite beams reinforced with prestressed prisms and instrumented with Bragg Grating fiber optic sensors. The experimental techniques using those sensors for evaluating their behavior at service load stages, and the potential of this technique for on-line, real-time monitoring of existing constructed concrete structures are presented.


Blood ◽  
2010 ◽  
Vol 115 (3) ◽  
pp. 443-452 ◽  
Author(s):  
Daniel Lewandowski ◽  
Vilma Barroca ◽  
Frédéric Ducongé ◽  
Jan Bayer ◽  
Jeanne Tran Van Nhieu ◽  
...  

Abstract Few techniques are available to characterize in vivo the early cellular dynamics of long-term reconstitution of hematopoiesis after transplantation of hematopoietic stem cells (HSCs) after lethal irradiation. Using a fiber-optic imaging system, we track the early steps of in vivo recruitment and proliferation of Lin−Sca-1+c-Kit+CD34− (LSKCD34−) HSCs highly enriched in HSCs and transplanted into lethally irradiated mice. Recruitment of the transplanted LSKCD34− hematopoietic cells first occurs in the femoral head and is continuous during 24 hours. Quantification of the fluorescence emitted by the transplanted hematopoietic cells shows that proliferation of LSKCD34− hematopoietic cells in the femoral head was potent 3 days after transplantation. Using a development of this fiber-optic imaging system, we show that the transplanted LSKCD34− hematopoietic cells are associated with vascularized structures as early as 5 hours after transplantation. This early association is dependent on reactive oxygen species (ROS) partly through the regulation of vascular cell adhesion molecule-1 expression on endothelial cells and is followed by a ROS-dependent proliferation of LSKCD34− hematopoietic cells. This new in vivo imaging technique permits the observation of the early steps of hematopoietic reconstitution by HSCs in long bones and shows a new role of ROS in the recruitment of HSCs by bone marrow endothelial cells.


2018 ◽  
Vol 25 (3) ◽  
pp. 717-728 ◽  
Author(s):  
Anders Filsøe Pedersen ◽  
Hugh Simons ◽  
Carsten Detlefs ◽  
Henning Friis Poulsen

The fractional Fourier transform (FrFT) is introduced as a tool for numerical simulations of X-ray wavefront propagation. By removing the strict sampling requirements encountered in typical Fourier optics, simulations using the FrFT can be carried out with much decreased detail, allowing, for example, on-line simulation during experiments. Moreover, the additive index property of the FrFT allows the propagation through multiple optical components to be simulated in a single step, which is particularly useful for compound refractive lenses (CRLs). It is shown that it is possible to model the attenuation from the entire CRL using one or two effective apertures without loss of accuracy, greatly accelerating simulations involving CRLs. To demonstrate the applicability and accuracy of the FrFT, the imaging resolution of a CRL-based imaging system is estimated, and the FrFT approach is shown to be significantly more precise than comparable approaches using geometrical optics. Secondly, it is shown that extensive FrFT simulations of complex systems involving coherence and/or non-monochromatic sources can be carried out in minutes. Specifically, the chromatic aberrations as a function of source bandwidth are estimated, and it is found that the geometric optics greatly overestimates the aberration for energy bandwidths of around 1%.


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