Plasma anti-oxidant status in malaria

DM otherwise diabetes is now a days an epidemic with the percentage of patient population rising to almost 10% of the world population. Out of all the DM complications, cataract leads the way contributing to disabilities to about 60% of diabetic population. But the pathogenesis of DM cataract is still a half-understood area of medicine there by posing a problem in the therapy. The data that we have till now gives us enough evidence to advocate the oxidative stress has a major role for the pathogenesis of DM complications like DMnephropathy, DMneuropathy, and cardiac hypertrophy, which suggests the oxidative stress is a central feature of diabetes. In the current research, the pharmacological evaluation of Fisetin for its DM based anti-cataract property was performed. This research concentrates to estimate the possible involvement of Nrf-2 / heme oxygenase (HO)-pathway in the observed therapeutic effect, if any. The data obtained in this study also indicate that the observed beneficial effects mainly due to activation of Nrf2/HO-1 pathway. These effects probably result in increased tissue anti-oxidant status as well as decreased free radical production, which ultimately responsible for the observed beneficial effects of Fisetin against hyperglycemia-induced cataract.

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Oral administration of potassium dichromate inhibits brush border membrane enzymes and alters anti-oxidant status of rat intestine

Archives of Toxicology ◽

10.1007/s00204-008-0311-0 ◽

2008 ◽

Vol 82 (12) ◽

pp. 951-958 ◽

Cited By ~ 14

Author(s):

N. A. Arivarasu ◽

Sabiha Fatima ◽

Riaz Mahmood

Keyword(s):

Oral Administration ◽

Brush Border ◽

Brush Border Membrane ◽

Potassium Dichromate ◽

Rat Intestine ◽

Membrane Enzymes ◽

Anti Oxidant ◽

Oxidant Status ◽

Brush Border Membrane Enzymes

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Evaluation of Assays for Measurement of Serum (Anti)oxidants in Hemodialysis Patients

BioMed Research International ◽

10.1155/2014/843157 ◽

2014 ◽

Vol 2014 ◽

pp. 1-8 ◽

Cited By ~ 6

Author(s):

Tatjana Ruskovska ◽

Eugene H. J. M. Jansen ◽

Risto Antarorov

Keyword(s):

Oxidative Stress ◽

Statistical Significance ◽

Hemodialysis Patients ◽

Chronic Hemodialysis ◽

Total Serum ◽

Antioxidant Assays ◽

Hemodialysis Session ◽

Anti Oxidant ◽

Oxidant Status ◽

Healthy Persons

Background. Various biomarkers and assays have been used for assessment of (anti)oxidant status in hemodialysis patients, including those intended for measurement of serum total (anti)oxidants, most often as a part of panel biomarkers.Methods. Serum (anti)oxidant status was measured in 32 chronically hemodialyzed patients and in 47 healthy persons, using two oxidations and three antioxidant assays.Results. The patients before the hemodialysis session have had higher values of total oxidants in comparison to the healthy persons, with a further increase during the hemodialysis. These findings were confirmed with both oxidation assays, but they differ in the percentage of increase and the statistical significance. All three antioxidant assays showed significantly higher values of the total serum antioxidants in the patients before the hemodialysis session in comparison to the healthy persons, and their significant decrease during the hemodialysis. However, the assays differ in the percentage of decrease, its statistical significance, and the correlations with uric acid.Conclusion. The variability of results of total (anti)oxidants which are obtained using different assays should be taken into account when interpreting data from clinical studies of oxidative stress, especially in complex pathologies such as chronic hemodialysis.

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