Role of Salicylic Acid in Mitigating Cadmium Toxicity in Plants

Abstract Cadmium (Cd+2) is a potentially toxic element that inhibits growth and development of several species of plants along with Silybum marianum (L.) Gaertn which is an essential medicinal plant belonging to family Asteraceae. The exogenous application with 0.25µM Salicylic acid (SA) and 10µM hydrogen peroxide (H2O2) to ameliorate harmful effects of cadmium (500 µM) on milk thistle were studied that were grown at two different ecological zones of Balochistan province of Pakistan i.e. Quetta (Qta) and Turbat (Tbt). The design of experiment was Randomized Complete Block Design (RCBD) with three replicates. Application of SA and H2O2, priming (P), Foliar spray (FS) and combinational treatments (P+FS) were highly helpful in alleviating the negative role of cadmium toxicity. The essential nutrients i.e. nitrate (NO3-), calcium (Ca2+) and potassium (K) were affected by Cd+2 induced toxicity however, the substantial role of SA and H2O2 widely helped to reduce the cadmium stress and boosted up the plant nutrients content. In a nutshell, exogenous treatments of SA and H2O2 enhanced the yield potential along with highest silymarin contents in milk thistle seeds which is of prime significance for its medicinal importance in treatment of liver diseases. The data obtained in this study highly recommend the priming and foliar spray of SA and H2O2 on milk thistle plants, as the best solution to alleviative the cadmium toxicity which will ultimately leads to better growth and yield of the plants.

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Salicylic Acid Signals Plant Defence against Cadmium Toxicity

International Journal of Molecular Sciences ◽

10.3390/ijms20122960 ◽

2019 ◽

Vol 20 (12) ◽

pp. 2960 ◽

Cited By ~ 8

Author(s):

Bin Guo ◽

Chen Liu ◽

Yongchao Liang ◽

Ningyu Li ◽

Qinglin Fu

Keyword(s):

Salicylic Acid ◽

Second Messengers ◽

Cadmium Toxicity ◽

Plant Defence ◽

Adaptive Responses ◽

Antioxidant Defence ◽

Signalling Molecule ◽

Antioxidant Defence System ◽

Wall Construction

Salicylic acid (SA), as an enigmatic signalling molecule in plants, has been intensively studied to elucidate its role in defence against biotic and abiotic stresses. This review focuses on recent research on the role of the SA signalling pathway in regulating cadmium (Cd) tolerance in plants under various SA exposure methods, including pre-soaking, hydroponic exposure, and spraying. Pretreatment with appropriate levels of SA showed a mitigating effect on Cd damage, whereas an excessive dose of exogenous SA aggravated the toxic effects of Cd. SA signalling mechanisms are mainly associated with modification of reactive oxygen species (ROS) levels in plant tissues. Then, ROS, as second messengers, regulate a series of physiological and genetic adaptive responses, including remodelling cell wall construction, balancing the uptake of Cd and other ions, refining the antioxidant defence system, and regulating photosynthesis, glutathione synthesis and senescence. These findings together elucidate the expanding role of SA in phytotoxicology.

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Role of Salicylic Acid in Alleviating Cadmium Toxicity in Rice Roots

Journal of Plant Nutrition ◽

10.1080/01904160601171835 ◽

2007 ◽

Vol 30 (3) ◽

pp. 427-439 ◽

Cited By ~ 21

Author(s):

Bin Guo ◽

Yongchao Liang ◽

Zhaojun Li ◽

Wei Guo

Keyword(s):

Salicylic Acid ◽

Cadmium Toxicity ◽

Rice Roots

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ROLE OF SALICYLIC ACID IN REGULATION OF CADMIUM TOXICITY IN WHEAT (TRITICUM AESTIVUML.)

Journal of Plant Nutrition ◽

10.1080/01904167.2010.489984 ◽

2010 ◽

Vol 33 (10) ◽

pp. 1460-1471 ◽

Cited By ~ 8

Author(s):

Helal Ragab Moussa ◽

Sabah Mohamed El-Gamal

Keyword(s):

Salicylic Acid ◽

Cadmium Toxicity

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INVESTIGATION OF SALICYLIC ACID-INDUCED CHANGE ON FLAVONOIDS PRODUCTION UNDER CADMIUM TOXICITY IN BUCKWHEAT (FAGOPYRUM ESCULENTUM MOENCH) PLANTS

EUREKA Life Sciences ◽

10.21303/2504-5695.2019.00986 ◽

2019 ◽

Vol 5 ◽

pp. 13-18

Author(s):

Yana Kavulych ◽

Myroslava Kobyletska ◽

Olga Terek

Keyword(s):

Salicylic Acid ◽

Cadmium Chloride ◽

Cadmium Toxicity ◽

Cadmium Stress ◽

Fagopyrum Esculentum ◽

Important Indicator ◽

Fagopyrum Esculentum Moench ◽

Tolerance To Cadmium ◽

Chelating Compounds

Salicylic acid (SA) is an imperative endogenous plant hormone. It is considered as one of the most important signaling molecule, involved in both abiotic and biotic stress tolerance. Application of optimal concentrations (0,05 mM) of SA enhances plants tolerance to cadmium stress by modulating levels of several metabolites, including components of antioxidative defense, osmolytes, secondary metabolites, and metal-chelating compounds. We showed that when SA and Cd were applied simultaneously, the damage was less pronounced than without SA. SA treatment itself also caused the oxidative stress, but decreased flavonoids content, regulated phenolic synthesis and lignin formation. Thus, the main purpose was to investigate how SA treatment, used prior the Cd stress, prevented the damaging heavy metal effects in buckwheat plants. And show that regulation of flavonoids and lignin formation are an important indicator of stability and stress resistance. The obtained data will expand the knowledge about the role of phenolic compounds and the action of salicylate under the cadmium chloride conditions. Also data with this type of buckwheat – Fagopyrum esculentum Moench, Rubra variety under the action of cadmium chloride and salicylic acid not found.

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The role of endogenous nitric oxide in salicylic acid-induced up-regulation of ascorbate-glutathione cycle involved in salinity tolerance of pepper (Capsicum annuum L.) plants

Plant Physiology and Biochemistry ◽

10.1016/j.plaphy.2019.11.040 ◽

2020 ◽

Vol 147 ◽

pp. 10-20 ◽

Cited By ~ 8

Author(s):

Cengiz Kaya ◽

Muhammad Ashraf ◽

Mohammed Nasser Alyemeni ◽

Parvaiz Ahmad

Keyword(s):

Nitric Oxide ◽

Salicylic Acid ◽

Capsicum Annuum ◽

Salinity Tolerance ◽

Capsicum Annuum L ◽

Endogenous Nitric Oxide ◽

Glutathione Cycle

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Salicylic Acid Accumulation Controlled by LSD1 Is Essential in Triggering Cell Death in Response to Abiotic Stress

Cells ◽

10.3390/cells10040962 ◽

2021 ◽

Vol 10 (4) ◽

pp. 962

Author(s):

Maciej Jerzy Bernacki ◽

Anna Rusaczonek ◽

Weronika Czarnocka ◽

Stanisław Karpiński

Keyword(s):

Cell Death ◽

Salicylic Acid ◽

Abiotic Stress ◽

Wild Type ◽

Pr Genes ◽

Genes Expression ◽

Salicylic Acid Accumulation ◽

Cell Death Phenotype ◽

Insight Into

Salicylic acid (SA) is well known hormonal molecule involved in cell death regulation. In response to a broad range of environmental factors (e.g., high light, UV, pathogens attack), plants accumulate SA, which participates in cell death induction and spread in some foliar cells. LESION SIMULATING DISEASE 1 (LSD1) is one of the best-known cell death regulators in Arabidopsis thaliana. The lsd1 mutant, lacking functional LSD1 protein, accumulates SA and is conditionally susceptible to many biotic and abiotic stresses. In order to get more insight into the role of LSD1-dependent regulation of SA accumulation during cell death, we crossed the lsd1 with the sid2 mutant, caring mutation in ISOCHORISMATE SYNTHASE 1(ICS1) gene and having deregulated SA synthesis, and with plants expressing the bacterial nahG gene and thus decomposing SA to catechol. In response to UV A+B irradiation, the lsd1 mutant exhibited clear cell death phenotype, which was reversed in lsd1/sid2 and lsd1/NahG plants. The expression of PR-genes and the H2O2 content in UV-treated lsd1 were significantly higher when compared with the wild type. In contrast, lsd1/sid2 and lsd1/NahG plants demonstrated comparability with the wild-type level of PR-genes expression and H2O2. Our results demonstrate that SA accumulation is crucial for triggering cell death in lsd1, while the reduction of excessive SA accumulation may lead to a greater tolerance toward abiotic stress.

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Protective role of l ‐threonine against cadmium toxicity in Saccharomyces cerevisiae

Journal of Basic Microbiology ◽

10.1002/jobm.202100012 ◽

2021 ◽

Author(s):

Linru Huang ◽

Zhijia Fang ◽

Jian Gao ◽

Jingwen Wang ◽

Yongbin Li ◽

...

Keyword(s):

Saccharomyces Cerevisiae ◽

Cadmium Toxicity ◽

Protective Role

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Halloysite nanotubes filled with salicylic acid and sodium diclofenac: effects of vacuum pumping on loading and release properties

Journal of Nanostructure in Chemistry ◽

10.1007/s40097-021-00391-z ◽

2021 ◽

Author(s):

Lorenzo Lisuzzo ◽

Giuseppe Cavallaro ◽

Stefana Milioto ◽

Giuseppe Lazzara

Keyword(s):

Salicylic Acid ◽

Release Kinetics ◽

Halloysite Nanotubes ◽

Drug Molecules ◽

Sodium Diclofenac ◽

Tunable Release ◽

Feature Based ◽

Kinetics Of ◽

Filling Mechanism

AbstractIn this work, we investigated the effects of the vacuum pumping on both the loading efficiencies and the release kinetics of halloysite nanotubes filled with drug molecules dissolved in ethanol. As model drugs, salicylic acid and sodium diclofenac were selected. For comparison, the loading of the drug molecules was conducted on platy kaolinite to explore the key role of the hollow tubular morphology on the filling mechanism of halloysite. The effects of the pressure conditions used in the loading protocol were interpreted and discussed on the basis of the thermodynamic results provided by Knudsen thermogravimetry, which demonstrated the ethanol confinement inside the halloysite cavity. Several techniques (TEM, FTIR spectroscopy, DLS and $$\zeta$$ ζ -potential experiments) were employed to characterize the drug filled nanoclays. Besides, release kinetics of the drugs were studied and interpreted according to the loading mechanism. This work represents a further step for the development of nanotubular carriers with tunable release feature based on the loading protocol and drug localization into the carrier. Graphic abstract The filling efficiency of halloysite nanotubes is enhanced by the reduction of the pressure conditions used in the loading protocol.

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