Efflux transporters in anti-cancer drug resistance: Molecular and functional identification and characterization of multidrug resistance proteins (MRPs/ABCCs)

2020 ◽  
pp. 31-65
Author(s):  
Brayden D. Whitlock ◽  
Elaine M. Leslie
Keyword(s):  
Drug Resistance ◽  
Multidrug Resistance ◽  
Cancer Drug ◽  
Multidrug Resistance Proteins ◽  
Functional Identification ◽  
Resistance Proteins ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Identification And Characterization

Major obstacles to doxorubicin therapy: Cardiotoxicity and drug resistance

2019 ◽  
Vol 26 (2) ◽  
pp. 434-444 ◽  
Author(s):  
Hamdan S Al-malky ◽  
Sameer E Al Harthi ◽  
Abdel-Moneim M Osman
Keyword(s):  
Drug Resistance ◽  
Cancer Drug ◽  
Multidrug Resistance Proteins ◽  
Drug Induced ◽  
Doxorubicin Resistance ◽  
Resistance Proteins ◽  
Cancer Drug Resistance ◽  
Underlying Mechanisms ◽  
Secondary Information ◽  
Ebsco Host

Background Doxorubicin is one of the most commonly prescribed and time-tested anticancer drugs. Although being considered as a first line drug in different types of cancers, the two main obstacles to doxorubicin therapy are drug-induced cardiotoxicity and drug resistance. Method The study utilizes systemic reviews on publications of previous studies obtained from scholarly journal databases including PubMed, Medline, Ebsco Host, Google Scholar, and Cochrane. The study utilizes secondary information obtained from health organizations using filters and keywords to sustain information relevancy. The study utilizes information retrieved from studies captured in the peer-reviewed journals on “doxorubicin-induced cardiotoxicity” and “doxorubicin resistance.” Discussion and results The exact mechanisms of cardiotoxicity are not known; various hypotheses are studied. Doxorubicin can lead to free radical generation in various ways. The commonly proposed underlying mechanisms promoting doxorubicin resistance are the expression of multidrug resistance proteins as well as other causes. Conclusion In this review, we have described the major obstacles to doxorubicin therapy, doxorubicin-induced cardiotoxicity as well as the mechanisms of cancer drug resistance and in following the treatment failures.

Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance

2020 ◽  
Vol 20 (9) ◽  
pp. 779-787
Author(s):  
Kajal Ghosal ◽  
Christian Agatemor ◽  
Richard I. Han ◽  
Amy T. Ku ◽  
Sabu Thomas ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Dna Repair ◽  
Fanconi Anemia ◽  
Cancer Drug ◽  
Drug Resistant ◽  
Cancer Drugs ◽  
Repair Pathway ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Cancerous Cells

Chemotherapy employs anti-cancer drugs to stop the growth of cancerous cells, but one common obstacle to the success is the development of chemoresistance, which leads to failure of the previously effective anti-cancer drugs. Resistance arises from different mechanistic pathways, and in this critical review, we focus on the Fanconi Anemia (FA) pathway in chemoresistance. This pathway has yet to be intensively researched by mainstream cancer researchers. This review aims to inspire a new thrust toward the contribution of the FA pathway to drug resistance in cancer. We believe an indepth understanding of this pathway will open new frontiers to effectively treat drug-resistant cancer.

scholarly journals The Emerging Role of Extracellular Vesicle-Mediated Drug Resistance in Cancers: Implications in Advanced Prostate Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Carolina Soekmadji ◽  
Colleen C. Nelson
Keyword(s):  
Prostate Cancer ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Advanced Prostate Cancer ◽  
Control Cell ◽  
Extracellular Vesicle ◽  
Multidrug Resistance Proteins ◽  
Acquired Drug Resistance ◽  
Resistance Proteins

Emerging evidence has shown that the extracellular vesicles (EVs) regulate various biological processes and can control cell proliferation and survival, as well as being involved in normal cell development and diseases such as cancers. In cancer treatment, development of acquired drug resistance phenotype is a serious issue. Recently it has been shown that the presence of multidrug resistance proteins such as Pgp-1 and enrichment of the lipid ceramide in EVs could have a role in mediating drug resistance. EVs could also mediate multidrug resistance through uptake of drugs in vesicles and thus limit the bioavailability of drugs to treat cancer cells. In this review, we discussed the emerging evidence of the role EVs play in mediating drug resistance in cancers and in particular the role of EVs mediating drug resistance in advanced prostate cancer. The role of EV-associated multidrug resistance proteins, miRNA, mRNA, and lipid as well as the potential interaction(s) among these factors was probed. Lastly, we provide an overview of the current available treatments for advanced prostate cancer, considering where EVs may mediate the development of resistance against these drugs.

Targeting the ubiquitin-proteasome pathway to overcome anti-cancer drug resistance

2020 ◽  
Vol 48 ◽  
pp. 100663 ◽  
Author(s):  
Silpa Narayanan ◽  
Chao-Yun Cai ◽  
Yehuda G. Assaraf ◽  
Hui-Qin Guo ◽  
Qingbin Cui ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Drug ◽  
Ubiquitin Proteasome Pathway ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway

Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines

2007 ◽  
Vol 30 (1) ◽  
pp. 36-44 ◽  
Author(s):  
Femke M. van de Water ◽  
Johanna M. Boleij ◽  
Janny G.P. Peters ◽  
Frans G.M. Russel ◽  
Rosalinde Masereeuw
Keyword(s):  
Multidrug Resistance ◽  
Cell Lines ◽  
Rat Kidney ◽  
Intestinal Cell ◽  
Multidrug Resistance Proteins ◽  
Resistance Proteins ◽  
P Glycoprotein ◽  
Intestinal Cell Lines

scholarly journals A Compendium of Information on the Lysosome

2021 ◽  
Vol 9 ◽  
Author(s):  
Nadia Bouhamdani ◽  
Dominique Comeau ◽  
Sandra Turcotte
Keyword(s):  
Drug Resistance ◽  
Scientific Knowledge ◽  
Targeted Therapies ◽  
Cancer Drug ◽  
Functional Changes ◽  
The Past ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Long Time ◽  
Signaling Organelles

For a long time, lysosomes were considered as mere waste bags for cellular constituents. Thankfully, studies carried out in the past 15 years were brimming with elegant and crucial breakthroughs in lysosome research, uncovering their complex roles as nutrient sensors and characterizing them as crucial multifaceted signaling organelles. This review presents the scientific knowledge on lysosome physiology and functions, starting with their discovery and reviewing up to date ground-breaking discoveries highlighting their heterogeneous functions as well as pending questions that remain to be answered. We also review the roles of lysosomes in anti-cancer drug resistance and how they undergo a series of molecular and functional changes during malignant transformation which lead to tumor aggression, angiogenesis, and metastases. Finally, we discuss the strategy of targeting lysosomes in cancer which could lead to the development of new and effective targeted therapies.

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