Recent advances in mass spectrometric and other analytical techniques for the identification of drug metabolites

2020 ◽  
pp. 39-71
Author(s):  
Jose Castro-Perez ◽  
Chandra Prakash
Keyword(s):  
Analytical Techniques ◽  
Mass Spectrometric ◽  
Drug Metabolites ◽  
Recent Advances

Recent advances in the mass spectrometric profiling of bacterial lipids

2021 ◽  
Vol 65 ◽  
pp. 145-153
Author(s):  
Neetika Jaisinghani ◽  
Jessica C. Seeliger
Keyword(s):  
Mass Spectrometric ◽  
Recent Advances

scholarly journals Olive oil from the 79 A.D. Vesuvius eruption stored at the Naples National Archaeological Museum (Italy)

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Raffaele Sacchi ◽  
Adele Cutignano ◽  
Gianluca Picariello ◽  
Antonello Paduano ◽  
Alessandro Genovese ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Oleic Acid ◽  
Olive Oil ◽  
Volatile Compounds ◽  
Radiocarbon Dating ◽  
Analytical Techniques ◽  
Mass Spectrometric ◽  
Hydroxy Fatty Acids ◽  
Glass Bottle ◽  
The World

Abstract Using a range of chromatographic, spectroscopic, and mass spectrometric analytical techniques, we characterized one of the “edible items” found at the Vesuvius archeological sites and guarded at the National Archaeological Museum of Naples (MANN) in Naples, Italy. We authenticated the specimen contained in a glass bottle (Mann-S1 sample) as originally olive oil and mapped the deep evolution throughout its 2000 years of storage. Triacylglycerols were completely hydrolyzed, while the resulting (hydroxy) fatty acids had partly condensed into rarely found estolides. A complex pattern of volatile compounds arose mainly from breakdown of oleic acid. With excellent approximation, radiocarbon dating placed the find at the time of the Plinian Mount Vesuvius eruption in 79 A.D., indicating that Mann-S1 is probably the oldest residue of olive oil in the world found in bulk amount (nearly 0.7 L).

Recent Advances in Analytical Techniques to Investigate Pesticide Poisoning of Wildlife

2000 ◽  
pp. 254-274
Author(s):  
Ainsley Jones ◽  
S. McGaw ◽  
L. Ross ◽  
C. McCoy ◽  
G. Turnbull ◽  
...  
Keyword(s):  
Analytical Techniques ◽  
Pesticide Poisoning ◽  
Recent Advances

Extraction and Chromatography-Mass Spectrometric Analysis of the Active Principles from Selected Chinese Herbs and Other Medicinal Plants

2003 ◽  
Vol 31 (06) ◽  
pp. 927-944 ◽  
Author(s):  
Xiaosuo Wang ◽  
Vimal Kapoor ◽  
George A. Smythe
Keyword(s):  
Mass Spectrometry ◽  
Analytical Techniques ◽  
Mass Spectrometric ◽  
Chinese Herbs ◽  
Spectrometric Analysis ◽  
Toxic Substances ◽  
Herbal Extracts ◽  
Active Components ◽  
Herbal Products ◽  
Isolation And Characterization

Medicinal herbs have a long history of use in the practice of traditional Chinese medicine and a substantial body of evidence has, over recent decades, demonstrated a range of important pharmacological properties. Western biomedical researchers are examining not only the efficacy of the traditional herbal products but, through the use of a range of bioassays and analytical techniques, are developing improved methods to isolate and characterize active components. This review briefly describes the different extraction methodologies used in the preparation of herbal extracts and reviews the utility of chromatography-mass spectrometry for the analysis of their active components. In particular, applications of gas or liquid chromatography with mass spectrometry for the isolation and characterization of active components of ginseng are critically assessed. The analysis of toxic substances from herb extracts with mass spectrometric techniques is also discussed along with the potential for mass spectrometric methods to investigate the proteomics of herbal extracts.

Capturing the Complexity and Dynamics of Positive Human Health

2017 ◽  
Author(s):  
Jonathan Rush ◽  
Anthony D. Ong ◽  
Scott M. Hofer ◽  
John L. Horn
Keyword(s):  
Positive Psychology ◽  
Human Health ◽  
Analytical Techniques ◽  
Well Being ◽  
Process Research ◽  
Considerable Extent ◽  
Recent Advances ◽  
Methodological Challenges ◽  
Research Designs ◽  
Measurement And Analysis

This chapter illustrates how recent advances in longitudinal methodology can be applied to diverse issues of interest to positive psychologists. The rules for doing research that can net the highest stakes in understanding are, to a considerable extent, the rules of design and measurement. The aim of the chapter is to describe how contemporary theories of well-being may be empirically evaluated using a variety of research designs and analytical techniques that can fully capture the complexity and dynamics of positive human health. Throughout, the chapter identifies unresolved methodological challenges associated with the measurement and analysis of between- and within-person phenomena and elaborates on the implications of these challenges for process research in positive psychology.

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