Morphological differences between regenerating salivary glands after salivary gland duct ligation and embryonic salivary glands

2020 ◽  
Vol 229 ◽  
pp. 151482
Author(s):  
Hitomi Ono Minagi ◽  
Yu Usami ◽  
Manabu Sakai ◽  
Takayoshi Sakai
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Duct Ligation ◽  
Gland Duct ◽  
Morphological Differences

scholarly journals Secondary Sjögren's in patients with systemic scleroderma

2019 ◽  
Vol 3 (23) ◽  
pp. 37-39
Author(s):  
E. I. Selifanova ◽  
M. S. Esayan
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Minor Salivary Gland ◽  
Systemic Scleroderma ◽  
Minor Salivary Glands ◽  
Minor Salivary Gland Biopsy ◽  
European Consensus ◽  
Salivary Gland Biopsy ◽  
Morphological Differences ◽  
Lymphoid Infiltration

The aim of the study was to investigate the morphological differences of the minor salivary glands in patients with secondary Sjögren's syndrome associated with systemic scleroderma (Scl-SS). Total of 40 patients were grouped according to the American–European Consensus Group criteria. Information about the duration of the disease was taken from the patients records. Sections of the minor salivary gland biopsy were reevaluated, and the lymphocyte focus score (FS), plasma cell focus, and fibrosis rates were all evaluated. The groups were formed according to the duration of the disease: less than and over 5 years.Results. Scl-SS leads to changes in both in the large salivary glands and in the MSG, manifested in the form of mucoid swelling, fibrinoid changes, hyalinosis and sclerosis. In patients with Scl-SS the progression of the process leads to the destruction of the duct wall and to the focal and diffuse lymphoid infiltration.

scholarly journals Magainin-like immunoreactivity in human submandibular and labial salivary glands.

1990 ◽  
Vol 38 (11) ◽  
pp. 1531-1534 ◽  
Author(s):  
A Wolff ◽  
J E Moreira ◽  
C L Bevins ◽  
A R Hand ◽  
P C Fox
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Defense Mechanisms ◽  
Biologically Active ◽  
Epithelial Surface ◽  
Specific Staining ◽  
Mouse Tissues ◽  
Rabbit Igg ◽  
Gland Duct ◽  
Cryostat Sections

Magainins, antimicrobial peptides secreted by granular glands of frog skin, may be related to the high resistance to infections of this epithelial surface. The oral mucosa of healthy individuals is another tissue in which infection is not frequent, probably owing to the activity of potent salivary and mucosal defense mechanisms. To investigate if magainin-like factors are a component of these oral defense mechanisms, human and animal minor (mucosal) and major salivary glands were examined by immunohistochemistry, using a polyclonal rabbit anti-magainin antibody. Cryostat sections of (para) formaldehyde-fixed tissues were incubated with the antibody and then stained with fluorescein-complexed anti-rabbit IgG. Specific staining was observed in the apical portion of the cytoplasm of ductal epithelial cells of human submandibular and labial salivary glands. Diffuse staining was present in submandibular acinar cells. Bovine, rat, hamster, and mouse tissues were unreactive. The presence of magainin-like substances in human salivary gland duct cells is consistent with reports of the occurrence of other biologically active substances in salivary gland ducts.

Histopathological and morphological alterations in salivary gland of House fly induced by oral administration Thiamethoxam.

2018 ◽  
Vol 3 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Karim Mohammed Xider
Keyword(s):  
Salivary Gland ◽  
Cell Membrane ◽  
Oral Administration ◽  
Peak Concentration ◽  
Active Component ◽  
House Fly ◽  
Morphological Alterations ◽  
Gland Tissue ◽  
Gland Duct ◽  
Feeding Process

The current work the effect of Actara insecticide belongs to chemical family Neonicotinoid. The active component of thiamethoxam in three concentrations: 0.750 ppm, 1.5 ppm and 2.25ppm   on adult house fly salivary glands. Histopathological and morphological effects revealed important alterations produced by this insecticide in histological and morphology of the adult house fly gland tissue categorized by increasing gland duct lumen diameter. These alterations are possibly related with excretion function of salivary gland might be accountable for removing this insecticide. Results show thiamethoxam is a powerful insecticide that performances histologically in salivary glant tissue, triggering alterations in the glands  form, cytoplasm  with extreme vacuolation ,disruption cell membrane, obvious disorganization tissues cells, terminating in progressive deteriorating phase with changes in nucleus glandular cell's, such alterations occurred together in its size and form of gland, disintegration of nucleus, and presence of apoptosis(fragmentation) nucleus, accelerating the process of glandular degeneration ,and interfering with feeding process of house fly particularly when the peak concentration of  insecticide  was used.

scholarly journals Saliva and its potential in covid-19 cannot be ignored: a point of view

2021 ◽  
pp. 1-5
Author(s):  
Sukhvinder Singh Oberoi ◽  
Shabina Sachdeva ◽  
Shibani Grover ◽  
Vivek Sharma
Keyword(s):  
Salivary Gland ◽  
Epithelial Cells ◽  
Human Body ◽  
Point Of View ◽  
High Potential ◽  
Healthy Human ◽  
Duct Cells ◽  
Gland Duct

Abstract It has been demonstrated that salivary gland duct cells have similar receptors as ACE2-positive cells/keratin epithelial cells of the lung which have high potential to be infected by SARS-CoV 2 virus. The aerosols carrying virus have penetration into the healthy human body and lungs via inhalation through nose or mouth.

scholarly journals Neurofibromin expression by normal salivary glands

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Eloá Borges Luna ◽  
Pâmella Pinho Montovani ◽  
Rafaela Elvira Rozza-de-Menezes ◽  
Karin Soares Cunha
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Acinar Cells ◽  
Staining Intensity ◽  
Neurofibromatosis 1 ◽  
Tissue Type ◽  
Sublingual Gland ◽  
Minor Salivary Glands ◽  
Expression Levels ◽  
Ductal Cells

AbstractIntroductionNeurofibromin, a protein encoded by theNF1gene, is mutated in neurofibromatosis 1, one of the most common genetic diseases. Oral manifestations are common and a high prevalence of hyposalivation was recently described in individuals with neurofibromatosis 1. Although neurofibromin is ubiquitously expressed, its expression levels vary depending on the tissue type and developmental stage of the organism. The role of neurofibromin in the development, morphology, and physiology of salivary glands is unknown and a detailed expression of neurofibromin in human normal salivary glands has never been investigated.AimTo investigate the expression levels and distribution of neurofibromin in acinar and ductal cells of major and minor salivary glands of adult individuals without NF1.Material and methodTen samples of morphologically normal major and minor salivary glands (three samples of each gland: parotid, submandibular and minor salivary; and one sample of sublingual gland) from individuals without neurofibromatosis 1 were selected to assess neurofibromin expression through immunohistochemistry. Immunoquantification was performed by a digital method.ResultsNeurofibromin was expressed in the cytoplasm of both serous and mucous acinar cells, as well as in ducts from all the samples of salivary glands. Staining intensity varied from mild to strong depending on the type of salivary gland and region (acini or ducts). Ducts had higher neurofibromin expression than acinar cells (p = 0.003). There was no statistical association between the expression of neurofibromin and the type of the salivary gland, considering acini (p = 0.09) or ducts (p = 0.50) of the four salivary glands (parotid, submandibular, minor salivary, and sublingual gland). Similar results were obtained comparing the acini (p = 0.35) and ducts (p = 0.50) of minor and major salivary glands. Besides, there was no correlation between the expression of neurofibromin and age (p = 0.08), and sex (p = 0.79) of the individuals, considering simultaneously the neurofibromin levels of acini and duct (n = 34).ConclusionNeurofibromin is expressed in the cytoplasm of serous and mucous acinar cells, and ductal cells of salivary glands, suggesting that this protein is important for salivary gland function.

scholarly journals Acute salivary gland hypofunction in the duct ligation model in the absence of inflammation

Oral Diseases ◽  
2008 ◽  
Vol 14 (6) ◽  
pp. 520-528 ◽  
Author(s):  
PN Correia ◽  
GH Carpenter ◽  
SM Osailan ◽  
KL Paterson ◽  
GB Proctor
Keyword(s):  
Salivary Gland ◽  
Duct Ligation ◽  
Salivary Gland Hypofunction

Trypanosome infections and survival in tsetse

Parasitology ◽  
1998 ◽  
Vol 116 (S1) ◽  
pp. S23-S28 ◽  
Author(s):  
I. Maudlin ◽  
S. C. Welburn ◽  
P. J. M. Milligan
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Trypanosoma Brucei ◽  
Glossina Morsitans Morsitans ◽  
Trypanosoma Congolense ◽  
Vectorial Capacity ◽  
Trypanosome Infection ◽  
Trypanosoma Brucei Rhodesiense ◽  
Glossina Morsitans ◽  
Differential Effects

SummaryThe effect of trypanosome infection on vector survival was observed in a line of Glossina morsitans morsitans selected for susceptibility to trypanosome infection. The differential effects of midgut and salivary gland infections on survival were examined by exposing flies to infection with either Trypanosoma congolense which colonizes midgut and mouthparts or Trypanosoma brucei rhodesiense which colonizes midgut and salivary glands. A comparison of the survival distributions of uninfected flies with those exposed to infection showed that salivary gland infection significantly reduces tsetse survival; midgut infection had little or no effect on the survival of tsetse. The significance of these findings is discussed in relation to the vectorial capacity of wild flies.

First Insights into the Molecular Basis of Pleomorphic Adenomas of the Salivary Glands

2000 ◽  
Vol 14 (1) ◽  
pp. 81-83 ◽  
Author(s):  
M.L. Voz ◽  
W.J.M. Van de Ven ◽  
K. Kas
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Benign Tumor ◽  
Salivary Gland Tumor ◽  
Transitional Zone ◽  
Chromosome 8 ◽  
Gland Tumor ◽  
Histopathological Classification ◽  
Pleomorphic Adenomas ◽  
Chromosomal Changes

Pleomorphic adenoma, or mixed tumor of the salivary glands, is a benign tumor originating from the major and minor salivary glands. Eighty-five percent of these tumors are found in the parotid gland, 10% in the minor (sublingual) salivary glands, and 5% in the submandibular gland. It is the most common type of salivary gland tumor, accounting for almost 50% of all neoplasms in these organs. In fact, after the first observation of recurrent loss of chromosome 22 in meningioma, this was the second type of benign tumor for which non-random chromosomal changes were reported. The rate of malignant change with the potential to metastasize has been reported to be only 2 to 3%, and only a few cases of metastasizing pleomorphic salivary gland adenomas have been described to date. The fact that these tumors arise in organs located in an ontogenetic transitional zone, a region where endoderm and ectoderm meet, might be one of the reasons for the often-problematic histopathological classification. This type of benign tumor has been cytogenetically very well-characterized, with several hundreds of tumors karyotyped. In addition to the cytogenetic subgroup with an apparently normal diploid stemline (making up approximately 30% of the cases), three major cytogenetic subgroups can be distinguished. In addition to a subgroup showing non-recurrent clonal abnormalities, another subgroup is composed of tumors with various translocations involving 12ql5. By far the largest cytogenetic subgroup, however, consists of tumors with chromosome 8 abnormalities, mainly showing translocations involving region 8ql2. The most frequently encountered aberration in this group is a t(3;8)(p21;q12).

Mesenchymal control over elongating and branching morphogenesis in salivary gland development

Development ◽  
1981 ◽  
Vol 66 (1) ◽  
pp. 209-221
Author(s):  
Hiroyuki Nogawa ◽  
Takeo Mizuno
Keyword(s):  
Salivary Gland ◽  
Salivary Glands ◽  
Submaxillary Gland ◽  
Branching Morphogenesis ◽  
Mouse Submaxillary Gland ◽  
Gland Development

Recombination of the epithelium and mesenchyme between quail anterior submaxillary gland (elongating type) and quail anterior lingual or mouse submaxillary gland (branching type) was effected in vitro to clarify whether the elongating morphogenesis was directed by the epithelial or the mesenchymal component. Quail anterior submaxillary epithelium recombined with quail anterior lingual or mouse submaxillary mesenchyme came to branch. Conversely, quail anterior lingual or 12-day mouse submaxillary epithelium recombined with quail anterior submaxillary mesenchyme came to elongate, though the mesenchyme was less effective with 13-day mouse submaxillary epithelium. These results suggest that the elongating or branching morphogenesis of quail salivary glands is controlled by the mesenchyme.

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