Expression of candidate genes of lipid metabolism in the Kazakhstani breeding simmental cattle

Blood lipid response to a given dietary intervention could be determined by the effect of diet, gene variants or gene–diet interactions. The objective of the present study was to investigate whether variants in presumed nutrient-sensitive genes involved in lipid metabolism modified lipid profile after weight loss and in response to a given diet, among overweight European adults participating in the Diet Obesity and Genes study. By multiple linear regressions, 240 SNPs in twenty-four candidate genes were investigated for SNP main and SNP–diet interaction effects on total cholesterol, LDL-cholesterol, HDL-cholesterol and TAG after an 8-week low-energy diet (only main effect), and a 6-monthad libitumweight maintenance diet, with different contents of dietary protein or glycaemic index. After adjusting for multiple testing, a SNP–dietary protein interaction effect on TAG was identified for lipin 1 (LPIN1) rs4315495, with a decrease in TAG of − 0·26 mmol/l per A-allele/protein unit (95 % CI − 0·38, − 0·14,P= 0·000043). In conclusion, we investigated SNP–diet interactions for blood lipid profiles for 240 SNPs in twenty-four candidate genes, selected for their involvement in lipid metabolism pathways, and identified one significant interaction betweenLPIN1rs4315495 and dietary protein for TAG concentration.

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Pathways of Lipid Metabolism in Marine Algae, Co-Expression Network, Bottlenecks and Candidate Genes for Enhanced Production of EPA and DHA in Species of Chromista

Marine Drugs ◽

10.3390/md11114662 ◽

2013 ◽

Vol 11 (11) ◽

pp. 4662-4697 ◽

Cited By ~ 119

Author(s):

Alice Mühlroth ◽

Keshuai Li ◽

Gunvor Røkke ◽

Per Winge ◽

Yngvar Olsen ◽

...

Keyword(s):

Lipid Metabolism ◽

Candidate Genes ◽

Marine Algae ◽

Enhanced Production ◽

Epa And Dha

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Transcriptome Analysis of the Oil-Rich Tea Plant, Camellia oleifera, Reveals Candidate Genes Related to Lipid Metabolism

PLoS ONE ◽

10.1371/journal.pone.0104150 ◽

2014 ◽

Vol 9 (8) ◽

pp. e104150 ◽

Cited By ~ 41

Author(s):

En-Hua Xia ◽

Jian-Jun Jiang ◽

Hui Huang ◽

Li-Ping Zhang ◽

Hai-Bin Zhang ◽

...

Keyword(s):

Lipid Metabolism ◽

Candidate Genes ◽

Transcriptome Analysis ◽

Tea Plant ◽

Camellia Oleifera

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Integrated in-depth bioinformatic analysis suggests RELCH/KIAA1468, LINC02341, and AKAP11 as candidate genes for ages at menarche and menopause

RESEARCH RESULTS IN BIOMEDICINE ◽

10.18413/2658-6533-2021-7-3-0-2 ◽

2021 ◽

Vol 7 (3) ◽

pp. 220-231

Author(s):

Volodymyr Dvornyk ◽

Keyword(s):

Lipid Metabolism ◽

Cell Survival ◽

Candidate Genes ◽

Bioinformatic Analysis ◽

Age At Menarche ◽

Biological Processes ◽

Genetic Associations ◽

Biological Mechanisms ◽

Natural Menopause ◽

Online Databases

Polymorphisms of the TNFRSF11A and TNFSF11 genes were reported for their association with age at menarche (AAM) and age at natural menopause (ANM). However, the biological mechanisms underlying this association remain largely unclear. The aim of the study: This study was to determine biological processes backing the observed genetic associations. Materials and methods: Fortyfour SNPs were analyzed using in silico approach and ten publicly available online databases and tools. Results: TNFRSF11A and TNFSF11 are highly pleiotropic genes that play a role in many metabolic processes. However, among that variety, lipid metabolism and cell survival and apoptosis seem the most biologically plausible mechanisms, through which these genes contribute to AAM and ANM. The analysis identified several mechanisms underlying the previously determined association of the TNFRSF11A and TNFSF11 genes with AAM and ANM and suggested RELCH/KIAA1468, LINC02341, and AKAP11 as new candidate genes for the traits.

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Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-α agonist ciprofibrate

Physiological Genomics ◽

10.1152/physiolgenomics.00064.2003 ◽

2003 ◽

Vol 15 (1) ◽

pp. 9-19 ◽

Cited By ~ 29

Author(s):

Fekadu Yadetie ◽

Astrid Laegreid ◽

Ingunn Bakke ◽

Waclaw Kusnierczyk ◽

Jan Komorowski ◽

...

Keyword(s):

Gene Expression ◽

Lipid Metabolism ◽

Candidate Genes ◽

Stress Responses ◽

Inflammatory Responses ◽

Sugar Metabolism ◽

Hepatocyte Proliferation ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Liver Gene

Fibrate class hypolipidemic drugs such as ciprofibrate activate the peroxisome proliferator-activated receptor-α (PPARα), which is involved in processes including lipid metabolism and hepatocyte proliferation in rodents. We examined the effects of ciprofibrate (50 mg/kg body wt per day for 60 days) on liver gene expression in rats using cDNA microarrays. The 60-day dosing period was chosen to elucidate both the metabolic and proliferative actions of this substance, while avoiding confounding effects from the hepatic carcinogenesis seen during more long-term stimulation. Ciprofibrate changed the expression of many genes including previously known PPARα agonist-responsive genes involved in processes such as lipid metabolism and inflammatory responses. In addition, many novel candidate genes involved in sugar metabolism, transcription, signal transduction, cell proliferation, and stress responses appeared to be differentially regulated in ciprofibrate-dosed rats. Ciprofibrate also resulted in significant increases in liver weight and hepatocyte proliferation. The cDNA microarray results were confirmed by Northern blot analysis for selected genes. This study thus identifies many genes that appear to be differentially regulated in ciprofibrate-dosed rats, and some of these are potential targets of PPARα. The functional diversity of these candidate genes suggests that most of them are likely to be differentially regulated as indirect consequence of the many processes affected by ciprofibrate in rodent liver. Although caution is advisable in the interpretation of genome-wide expression data, the genes identified in the present study provide candidates for further studies that may give new insight into the mechanisms of action of peroxisome proliferators.

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