Effects of obesity on periodontal tissue remodeling during orthodontic movement

2021 ◽  
Author(s):  
Camila Chierici Marcantonio ◽  
Andressa Vilas Boas Nogueira ◽  
Natalia Da Ponte Leguizamón ◽  
Rafael Scaf de Molon ◽  
Maria Eduarda Scordamaia Lopes ◽  
...  
Keyword(s):  
Tissue Remodeling ◽  
Periodontal Tissue ◽  
Orthodontic Movement ◽  
Periodontal Tissue Remodeling

scholarly journals Effect of orthodontic force on inflammatory periodontal tissue remodeling and expression of IL-6 and IL-8 in rats

2013 ◽  
Vol 6 (10) ◽  
pp. 757-761 ◽  
Author(s):  
Jian-Hao Yang ◽  
Zheng-Chen Li ◽  
Wei-Dong Kong ◽  
Wu Zhang ◽  
Ying-Ping Jia ◽  
...  
Keyword(s):  
Tissue Remodeling ◽  
Periodontal Tissue ◽  
Orthodontic Force ◽  
Periodontal Tissue Remodeling

scholarly journals Biomechanical Interfaces of Corticotomies on Periodontal Tissue Remodeling during Orthodontic Tooth Movement

Coatings ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
Ruojing Liu ◽  
Li Huang ◽  
Xiaoyue Xiao ◽  
Yuzhe Guan ◽  
Yukun Jiang ◽  
...  
Keyword(s):  
Alveolar Bone ◽  
Tooth Movement ◽  
Root Resorption ◽  
Orthodontic Tooth Movement ◽  
Tissue Remodeling ◽  
Sham Operation ◽  
Periodontal Tissue ◽  
Wnt Signal Pathway ◽  
Post Surgery ◽  
Periodontal Tissue Remodeling

Corticotomy is an effective approach in accelerating orthodontic tooth movement (OTM) in clinical treatment. Corticotomy causes regional acceleratory phenomenon (RAP) in the alveolar bone of surgical sites. However, the molecular mechanism of RAP after corticotomy remains unclear. Herein, we established a mouse model to study the biomechanical interfaces of corticotomy-assisted OTM and to investigate the histological responses and underlying cellular mechanism. A total of 144 male C57BL/6 mice were randomly assigned into four groups: corticotomy alone (Corti), sham operation (Sham), corticotomy with tooth movement (Corti + TM), and sham operation with tooth movement (Sham + TM). Nickel–titanium orthodontic springs were applied to trigger tooth movement. Mice were sacrificed on Post-Surgery Day (PSD) 3, 7, 14, 21, and 28 for radiographic, histological, immunohistochemical, and molecular biological analyses. The results reveal that corticotomy significantly promoted alveolar bone turnover and periodontal tissue remodeling. During orthodontic tooth movement, corticotomy significantly promoted osteogenic and proliferative activity, accelerated tooth movement, and eliminated root resorption by upregulating Wnt signal pathway.

Effects of electrical stimulation on periodontal tissue remodeling in rats

2012 ◽  
Vol 48 (2) ◽  
pp. 177-183 ◽  
Author(s):  
T. Tomofuji ◽  
D. Ekuni ◽  
T. Azuma ◽  
K. Irie ◽  
Y. Endo ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Tissue Remodeling ◽  
Periodontal Tissue ◽  
Periodontal Tissue Remodeling

scholarly journals Long Non-coding RNA FER1L4 Mediates the Autophagy of Periodontal Ligament Stem Cells Under Orthodontic Compressive Force via AKT/FOXO3 Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Yiping Huang ◽  
Hao Liu ◽  
Runzhi Guo ◽  
Yineng Han ◽  
Yuhui Yang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Periodontal Ligament ◽  
Tooth Movement ◽  
Orthodontic Tooth Movement ◽  
Compressive Force ◽  
Tissue Remodeling ◽  
Mechanical Force ◽  
Periodontal Tissue ◽  
Periodontal Ligament Stem Cells ◽  
Periodontal Tissue Remodeling

Orthodontic tooth movement is achieved by periodontal tissue remodeling triggered by mechanical force. It is essential to investigate the reaction of periodontal ligament stem cells (PDLSCs) for improving orthodontic therapeutic approaches. Autophagy is an endogenous defense mechanism to prevent mechanical damage of environmental change. Long non-coding RNAs (lncRNAs) are key regulators in gene regulation, but their roles are still largely uncharacterized in the reaction of PDLSCs during orthodontic tooth movement. In this study, we showed that autophagy was significantly induced in PDLSCs under compressive force, as revealed by the markers of autophagy, microtubule-associated protein light chain 3 (LC3) II/I and Beclin1, and the formation of autophagosomes. After the application of compressive force, lncRNA FER1L4 was strongly upregulated. Overexpression of FER1L4 increased the formation of autophagosome and autolysosomes in PDLSCs, while knockdown of FER1L4 reversed the autophagic activity induced by mechanical force. In mechanism, FER1L4 inhibited the phosphorylation of protein kinase B (AKT) and subsequently increased the nuclear translocation of forkhead box O3 (FOXO3) and thus mediated autophagic cascades under compressive strain. In mouse model, the expression of Lc3 as well as Fer1l4 was increased in the pressure side of periodontal ligament during tooth movement. These findings suggest a novel mechanism of autophagy regulation by lncRNA during periodontal tissue remodeling of orthodontic treatment.

Periodontal tissue response to orthodontic movement of teeth with infrabony pockets

1993 ◽  
Vol 103 (4) ◽  
pp. 313-319 ◽  
Author(s):  
Jan L. Wennström ◽  
Birgitta Lindskog Stokland ◽  
Sture Nyman ◽  
Birgit Thilander
Keyword(s):  
Tissue Response ◽  
Periodontal Tissue ◽  
Orthodontic Movement

scholarly journals Epithelial rests of Malassez: from latent cells to active participation in orthodontic movement

2017 ◽  
Vol 22 (3) ◽  
pp. 119-125
Author(s):  
Bianca Silva e Silva ◽  
Nathalia Carolina Fernandes Fagundes ◽  
Bárbara Catarina Lima Nogueira ◽  
José Valladares Neto ◽  
David Normando ◽  
...  
Keyword(s):  
Literature Review ◽  
Functional Activity ◽  
Periodontal Ligament ◽  
Potential Functions ◽  
Functional Structure ◽  
Tissue Structure ◽  
Periodontal Tissue ◽  
Orthodontic Movement ◽  
Epithelial Rests Of Malassez ◽  
Cellular Debris

ABSTRACT Introduction: The epithelial rests of Malassez (ERM) represent a group of cells in the periodontal ligament classically consisting of latent or quiescent structures associated with pathological processes. However, recent evidence shows that these structures cannot be considered only as cellular debris. The ERM is a major tissue structure, with functions in maintaining the homeostasis of periodontal tissue, including the maintenance of orthodontic movement. Objective: The present literature review aims at presenting the potential functions of ERM, with emphasis on orthodontic movement and the functional structure of the periodontium. Conclusion: ERM cells have a functional activity in modulation of orthodontic movement, trough their potential for differentiation, maintenance functions and the capacity of repairing periodontium.

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