scholarly journals First trimester serum angiogenic and anti-angiogenic factors in women with chronic hypertension for the prediction of preeclampsia

2020 ◽  
Vol 222 (4) ◽  
pp. 374.e1-374.e9 ◽  
Author(s):  
Diane Nzelu ◽  
Dan Biris ◽  
Theodoros Karampitsakos ◽  
Kypros K. Nicolaides ◽  
Nikos A. Kametas
Keyword(s):  
First Trimester ◽  
Angiogenic Factors ◽  
Chronic Hypertension

scholarly journals The Association of Familial Hypertension and Risk of Gestational Hypertension and Preeclampsia

2021 ◽  
Vol 18 (13) ◽  
pp. 7045
Author(s):  
Małgorzata Lewandowska
Keyword(s):  
Risk Factor ◽  
Pregnant Women ◽  
Odds Ratio ◽  
Independent Risk Factor ◽  
Gestational Hypertension ◽  
First Trimester ◽  
Chronic Hypertension ◽  
Modifiable Factors ◽  
The Family ◽  
Maternal Hypertension

It has not been established how history of hypertension in the father or mother of pregnant women, combined with obesity or smoking, affects the risk of main forms of pregnancy-induced hypertension. A cohort of 912 pregnant women, recruited in the first trimester, was assessed; 113 (12.4%) women developed gestational hypertension (GH), 24 (2.6%) developed preeclampsia (PE) and 775 women remained normotensive (a control group). Multiple logistic regression was used to calculate adjusted odds ratios (AOR) (and 95% confidence intervals) of GH and PE for chronic hypertension in the father or mother of pregnant women. Some differences were discovered. (1) Paternal hypertension (vs. absence of hypertension in the family) was an independent risk factor for GH (AOR-a = 1.98 (1.2–3.28), p = 0.008). This odds ratio increased in pregnant women who smoked in the first trimester (AOR-a = 4.71 (1.01–21.96); p = 0.048) or smoked before pregnancy (AOR-a = 3.15 (1.16–8.54); p = 0.024), or had pre-pregnancy overweight (AOR-a = 2.67 (1.02–7.02); p = 0.046). (2) Maternal hypertension (vs. absence of hypertension in the family) was an independent risk factor for preeclampsia (PE) (AOR-a = 3.26 (1.3–8.16); p = 0.012). This odds ratio increased in the obese women (AOR-a = 6.51 (1.05–40.25); p = 0.044) and (paradoxically) in women who had never smoked (AOR-a = 5.31 (1.91–14.8); p = 0.001). Conclusions: Chronic hypertension in the father or mother affected the risk of preeclampsia and gestational hypertension in different ways. Modifiable factors (overweight/obesity and smoking) may exacerbate the relationships in question, however, paradoxically, beneficial effects of smoking for preeclampsia risk are also possible. Importantly, paternal and maternal hypertension were not independent risk factors for GH/PE in a subgroup of women with normal body mass index (BMI).

scholarly journals Differential Diagnosis of Preeclampsia Based on Urine Peptidome Features Revealed by High Resolution Mass Spectrometry

Diagnostics ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1039
Author(s):  
Alexey S. Kononikhin ◽  
Natalia V. Zakharova ◽  
Viktoria A. Sergeeva ◽  
Maria I. Indeykina ◽  
Natalia L. Starodubtseva ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
High Resolution Mass Spectrometry ◽  
Gestational Hypertension ◽  
Characteristic Curve ◽  
First Trimester ◽  
Chronic Hypertension ◽  
High Resolution Mass ◽  
Diagnostic Potential ◽  
Resolution Mass

Preeclampsia (PE) is a severe pregnancy complication, which may be considered as a systemic response in the second half of pregnancy to physiological failures in the first trimester, and can lead to very serious consequences for the health of the mother and fetus. Since PE is often associated with proteinuria, urine proteomic assays may represent a powerful tool for timely diagnostics and appropriate management. High resolution mass spectrometry was applied for peptidome analysis of 127 urine samples of pregnant women with various hypertensive complications: normotensive controls (n = 17), chronic hypertension (n = 16), gestational hypertension (n = 15), mild PE (n = 25), severe PE (n = 25), and 29 patients with complicated diagnoses. Analysis revealed 3869 peptides, which mostly belong to 116 groups with overlapping sequences. A panel of 22 marker peptide groups reliably differentiating PE was created by multivariate statistics, and included 15 collagen groups (from COL1A1, COL3A1, COL2A1, COL4A4, COL5A1, and COL8A1), and single loci from alpha-1-antitrypsin, fibrinogen, membrane-associated progesterone receptor component 1, insulin, EMI domain-containing protein 1, lysine-specific demethylase 6B, and alpha-2-HS-glycoprotein each. ROC analysis of the created model resulted in 88% sensitivity, 96.8% specificity, and receiver operating characteristic curve (AUC) = 0.947. Obtained results confirm the high diagnostic potential of urinary peptidome profiling for pregnancy hypertensive disorders diagnostics.

scholarly journals OC04.03: Screening for pre-eclampsia in the first trimester based on maternal characteristics, biophysical parameters and angiogenic factors

2014 ◽  
Vol 44 (S1) ◽  
pp. 8-8
Author(s):  
F. Crovetto ◽  
F. Figueras ◽  
S. Triunfo ◽  
F. Crispi ◽  
V. Rodriguez-Sureda ◽  
...  
Keyword(s):  
First Trimester ◽  
Angiogenic Factors ◽  
Biophysical Parameters ◽  
Maternal Characteristics

scholarly journals Management of cervical heterotopic pregnancy with inevitable miscarriage

2019 ◽  
Vol 8 (2) ◽  
pp. 779
Author(s):  
Shyamala R. ◽  
Saranya Srikumar ◽  
Radhamany K.
Keyword(s):  
Stress Test ◽  
Tertiary Care ◽  
First Trimester ◽  
Chronic Hypertension ◽  
Medical Sciences ◽  
Intrauterine Pregnancy ◽  
Cervical Pregnancy ◽  
Uterine Arteries ◽  
Resource Setting ◽  
Low Resource Setting

The objective is to report a case of successful treatment of heterotopic cervical pregnancy resulting from IVF–ICSI conception. Case report from Amrita Institute of Medical sciences: a tertiary care referral hospital. A 47-year-old Primigravida, diagnosed with heterotopic cervical pregnancy at 6 weeks of gestation, presented with significant first trimester vaginal bleeding. Under IV sedation, Transvaginal ligation of descending cervical branches of the uterine arteries arrested the bleeding. The cervical pregnancy was successfully aborted with minimal bleeding and the intrauterine pregnancy was successfully maintained till 32 weeks, after which she required emergency preterm LSCS in view of Severe preeclampsia superimposed on chronic hypertension a non-reassuring non-stress test (NST). The intervention applied maybe used in treatment of heterotopic cervical pregnancy in a low resource setting to control the bleeding.

First trimester screening for early and late preeclampsia based on maternal characteristics, biophysical parameters, and angiogenic factors

2014 ◽  
Vol 35 (2) ◽  
pp. 183-191 ◽  
Author(s):  
Francesca Crovetto ◽  
Francesc Figueras ◽  
Stefania Triunfo ◽  
Fatima Crispi ◽  
Victor Rodriguez-Sureda ◽  
...  
Keyword(s):  
First Trimester ◽  
Angiogenic Factors ◽  
First Trimester Screening ◽  
Biophysical Parameters ◽  
Maternal Characteristics ◽  
Trimester Screening

25: First-trimester serum angiogenic factors and the risk of intrauterine fetal demise

2007 ◽  
Vol 197 (6) ◽  
pp. S12 ◽  
Author(s):  
Sarosh Rana ◽  
Alejandro Rauh-Hain ◽  
Ananth Karumanchi ◽  
Ravi Thadhani
Keyword(s):  
First Trimester ◽  
Angiogenic Factors ◽  
Fetal Demise ◽  
Intrauterine Fetal Demise

Association of first-trimester angiogenic factors with placental histological findings in late preeclampsia

2017 ◽  
Vol 7 ◽  
pp. 61
Author(s):  
Stefania Triunfo ◽  
Francesca Crovetto ◽  
Fatima Crispi ◽  
Victor Rodriguez-Sureda ◽  
Carmen Dominguez ◽  
...  
Keyword(s):  
First Trimester ◽  
Angiogenic Factors ◽  
Histological Findings

scholarly journals Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia

2019 ◽  
Vol 8 (9) ◽  
pp. 1429 ◽  
Author(s):  
Karoline Mayer-Pickel ◽  
Vassiliki Kolovetsiou-Kreiner ◽  
Christina Stern ◽  
Julia Münzker ◽  
Katharina Eberhard ◽  
...  
Keyword(s):  
Growth Factor ◽  
High Risk ◽  
Tyrosine Kinase ◽  
Serum Levels ◽  
First Trimester ◽  
Placental Growth Factor ◽  
Chronic Hypertension ◽  
First Trimester Screening ◽  
Trimester Screening ◽  
Plgf Ratio

Background: Soluble FMS-like Tyrosine Kinase 1 (sFlt-1) and placental growth factor (PlGF) have been reported to be highly predictive several weeks before the onset of preeclampsia. Objective: To investigate longitudinal changes of serum levels sFlt-1 and PlGF in pregnant women at high risk for the development of preeclampsia and to reveal an impact of aspirin on maternal serum concentrations of sFlt-1 and PlGF. Methods: This was a prospective longitudinal study in 394 women with various risk factors for the development of preeclampsia (chronic hypertension, antiphospholipid syndrome/APS or systemic lupus erythematosus/SLE, thrombophilia, women with a history of preeclampsia, pathologic first trimester screening for preeclampsia) and 68 healthy women. Serum levels of sFlt-1 and PlGF were measured prospectively at 4-week intervals (from gestational weeks 12 until postpartum). Results: The sFlt-1/PlGF ratio was significantly higher in women with an adverse obstetric outcome compared to women with a normal pregnancy, starting between 20 and 24 weeks of gestation. There was no effect of aspirin on sFlt-1/PlGF ratio in women with chronic hypertension, APS/SLE, thrombophilia and controls. The use of aspirin showed a trend towards an improvement of the sFlt-1/PlGF ratio in women with preeclampsia in a previous pregnancy and a significant effect on the sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia. Conclusions: Our findings reveal an impact of aspirin on sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia, strongly supporting its prophylactic use.

Sign in / Sign up

Export Citation Format

Share Document