scholarly journals Interstitial pneumonitis after COVID-19 vaccination: A report of three cases

2021 ◽  
Author(s):  
Takahiro Shimizu ◽  
Satoshi Watanabe ◽  
Tomoaki Yoneda ◽  
Masaki Kinoshita ◽  
Nanao Terada ◽  
...  
Keyword(s):  
Interstitial Pneumonitis

Clinical profile and predictors of severity in paediatric scrub typhus with pulmonary involvement

2021 ◽  
pp. 004947552110125
Author(s):  
Dinesh Kumar Narayanasamy ◽  
Thirunavukkarasu Arun Babu ◽  
Prakash Mathiyalagen
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Interstitial Pneumonitis ◽  
Clinical Characteristics ◽  
Scrub Typhus ◽  
Radiographic Finding ◽  
Maculopapular Rash ◽  
Pulmonary Involvement ◽  
Clearance Time ◽  
Fever Clearance Time

Pulmonary involvement is common in children with scrub typhus. Our paper outlines the clinical characteristics of pulmonary involvement and analyses the predictors of its severity. All scrub typhus serology-positive (optical density >0.5) children with pulmonary symptoms were included. Of 506 serology-positive scrub typhus cases, 256 (50.5%) had pulmonary symptoms, of whom 50 (9.8%) were severe. These severe cases were compared with non-severe cases. Interstitial pneumonitis was the commonest chest radiographic finding. Logistic regression analysis identified ‘fever clearance time’ >48 h, facial puffiness, maculopapular rash and anaemia to be significantly associated with severe pulmonary involvement.

scholarly journals Disseminated Bacillus Calmette–Guérin (BCG) infection and acute exacerbation of interstitial pneumonitis: an autopsy case report and literature review

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Gen Shimizu ◽  
Ryota Amano ◽  
Itaru Nakamura ◽  
Akane Wada ◽  
Masanobu Kitagawa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bladder Cancer ◽  
Acute Exacerbation ◽  
Interstitial Pneumonitis ◽  
Giant Cells ◽  
Epithelioid Cell ◽  
Bacillus Calmette Guerin ◽  
Antituberculosis Drugs ◽  
First Case ◽  
Intravesical Bcg

Abstract Background Intravesical administration of Bacillus Calmette–Guérin (BCG) has proven useful for treatment and prevention of recurrence of superficial bladder cancer and in situ carcinoma. However, fatal side effects such as disseminated infections may occur. Early diagnosis and accurate therapy for interstitial pneumonitis (IP) are important because exacerbation of IP triggered by infections is the major cause of death. Although some fatality reports have suggested newly appeared IP after intravesical BCG treatment, to our knowledge, there are no reports which have demonstrated acute exacerbation of existing IP. Moreover, autopsy is lacking in previous reports. We report the case of a patient with fatal IP exacerbation after BCG instillation and the pathological findings of the autopsy. Case presentation A 77-year-old man with a medical history of IP was referred to our hospital because of fever and malaise. He had received an intravesical injection of BCG 1 day before the admission. His fever reduced after the use of antituberculosis drugs, so he was discharged home. He was referred to our hospital again because of a high fever 7 days after discharge. On hospitalisation, he showed high fever and systemic exanthema. Hepatosplenomegaly and myelosuppression were also observed. Biopsies revealed multiple epithelioid cell granulomas with Langhans giant cells of the liver and bone marrow. Biopsy DNA analyses of Mycobacterium bovis in the bone marrow, sputum, and blood were negative. His oxygen demand worsened drastically, and the ground-glass shadow expanded on the computed tomography scan. He was diagnosed with acute exacerbation of existing IP. We recommenced the antituberculosis drugs with steroid pulse therapy, but he died on day 35 because of respiratory failure. The autopsy revealed a diffuse appearance of multiple epithelioid cell granulomas with Langhans giant cells in multiple organs, although BCG was not evident. Conclusions We report the first case of acute exacerbation of chronic IP by BCG infection. This is also the first case of autopsy of a patient with acute exacerbation of existing IP induced by intravesical BCG treatment. Whether the trigger of acute IP exacerbation is infection or hypersensitivity to BCG is still controversial, because pathological evidence confirming BCG infection is lacking. Physicians who administer BCG against bladder cancer should be vigilant for acute exacerbation of IP.

scholarly journals Morphology and pathogenesis of desquamative interstitial pneumonitis.

Thorax ◽  
1977 ◽  
Vol 32 (1) ◽  
pp. 7-18 ◽  
Author(s):  
E Valdivia ◽  
G Hensley ◽  
E P Leory ◽  
J Wu ◽  
W Jaeschke
Keyword(s):  
Interstitial Pneumonitis

FACTORS ASSOCIATED WITH INTERSTITIAL PNEUMONITIS AFTER BONE-MARROW TRANSPLANTATION FOR ACUTE LEUKAEMIA

The Lancet ◽  
1982 ◽  
Vol 319 (8269) ◽  
pp. 437-439 ◽  
Author(s):  
MortimerM. Bortin ◽  
HumphreyE.M. Kay ◽  
Robert Peter Gale ◽  
AlfredA. Rimm
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Interstitial Pneumonitis ◽  
Marrow Transplantation ◽  
Acute Leukaemia ◽  
Factors Associated

Diagnosis of Usual Interstitial Pneumonitis in the Absence of Honeycombing: Evaluation of Specific CT Criteria With Clinical Follow-Up in 38 Patients

2016 ◽  
Vol 206 (3) ◽  
pp. 472-480 ◽  
Author(s):  
James F. Gruden ◽  
Prasad M. Panse ◽  
Michael B. Gotway ◽  
Eric A. Jensen ◽  
Clinton V. Wellnitz ◽  
...  
Keyword(s):  
Interstitial Pneumonitis ◽  
Usual Interstitial Pneumonitis

scholarly journals Cyclosporine Treatment for Interstitial Pneumonitis Associated with Dermatomyositis/Polymyositis

1998 ◽  
Vol 37 (1) ◽  
pp. 103-103 ◽  
Author(s):  
Keiji MAEDA ◽  
Kiyoshi KOMUTA ◽  
Taro KURITANI ◽  
Tsuyoshi IGARASHI
Keyword(s):  
Interstitial Pneumonitis

ACUTE POISONING ASSOCIATED WITH INHALATION OF MERCURY VAPOR

PEDIATRICS ◽  
1958 ◽  
Vol 22 (4) ◽  
pp. 675-688
Author(s):  
Fred T. Matthes ◽  
Rudolph Kirschner ◽  
Martha D. Yow ◽  
James C. Brennan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Interstitial Pneumonitis ◽  
Laboratory Tests ◽  
Mercury Vapor ◽  
Acute Poisoning ◽  
Mercury Content ◽  
Sudden Onset ◽  
Pathologic Features ◽  
Early Use

Four cases of pneumonitis associated with the inhalation of mercury vapor are described in detail. Three of the four cases were fatal. The illness was characterized by the sudden onset of tachypnea, cough, fever, gastrointestinal disturbances and central nervous system manifestations. Ordinary laboratory tests were not helpful in establishing the diagnosis. Quantitative analysis of the urine for mercury was suggestive but not diagnostic. Roentgenograms of the lungs revealed interstitial pneumonitis. Analysis of tissue for mercury in the lungs, liver and spleen of two of the cases showed substantially increased mercury content. The outstanding pathologic features in the three fatal cases were erosive bronchitis and bronchiolitis, with severe interstitial pneumonitis. The presently accepted mode of therapy for acute poisoning due to ingestion of mercury is early use of BAL. Its use is probably also indicated in acute poisoning due to inhalation of mercury vapor. Supportive care in the form of oxygen, mist, and parenteral fluids is indicated.

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