ACUTE POISONING ASSOCIATED WITH INHALATION OF MERCURY VAPOR

PEDIATRICS ◽  
1958 ◽  
Vol 22 (4) ◽  
pp. 675-688
Author(s):  
Fred T. Matthes ◽  
Rudolph Kirschner ◽  
Martha D. Yow ◽  
James C. Brennan
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Interstitial Pneumonitis ◽  
Laboratory Tests ◽  
Mercury Vapor ◽  
Acute Poisoning ◽  
Mercury Content ◽  
Sudden Onset ◽  
Pathologic Features ◽  
Early Use

Four cases of pneumonitis associated with the inhalation of mercury vapor are described in detail. Three of the four cases were fatal. The illness was characterized by the sudden onset of tachypnea, cough, fever, gastrointestinal disturbances and central nervous system manifestations. Ordinary laboratory tests were not helpful in establishing the diagnosis. Quantitative analysis of the urine for mercury was suggestive but not diagnostic. Roentgenograms of the lungs revealed interstitial pneumonitis. Analysis of tissue for mercury in the lungs, liver and spleen of two of the cases showed substantially increased mercury content. The outstanding pathologic features in the three fatal cases were erosive bronchitis and bronchiolitis, with severe interstitial pneumonitis. The presently accepted mode of therapy for acute poisoning due to ingestion of mercury is early use of BAL. Its use is probably also indicated in acute poisoning due to inhalation of mercury vapor. Supportive care in the form of oxygen, mist, and parenteral fluids is indicated.

scholarly journals Aggressive pituitary lesion with a remarkably high Ki-67

2014 ◽  
Vol 58 (6) ◽  
pp. 656-660 ◽  
Author(s):  
Pedro Marques ◽  
Manuela Mafra ◽  
Carlos Calado ◽  
Anabela Martins ◽  
Joaquim Monteiro ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Severe Disease ◽  
Laboratory Data ◽  
Pituitary Tumors ◽  
Sudden Onset ◽  
World Health ◽  
Treatment Modalities ◽  
Pituitary Neoplasms ◽  
Ki 67

The uncommon aggressive pituitary tumors are named carcinomas when metastases are detected, either in the central nervous system and/or systemically. Some cases are associated with hormonal overproduction, but most are diagnosed because of local symptoms. These neoplasias are generally refractory to current treatments. A 51 year-old woman presented sudden onset of headache, left arm paresis and left facial hypoesthesia. Computed tomography scan and magnetic resonance imaging revealed a pituitary tumor invading the left sphenoidal and cavernous sinuses. Laboratory data excluded hormonal hypersecretion. The patient underwent transsphenoidal surgery and histological findings showed a neoplasia with Ki-67 estimated at 75%. Medical imaging excluded both a primary occult tumor and central nervous system or systemic dissemination. Three weeks postoperatively, neurological condition worsened, with new onset of ataxia, bilateral ptosis, ophthalmoplegia and an increase in the size of the lesion, leading to surgical intervention by craniotomy, followed by only a few sessions of radiotherapy, because of severe disease progression. Patient died nearly 2 months after the initial manifestations. This case illustrates the aggressiveness of some pituitary lesions, the limited efficacy of current treatment modalities such as surgery or radiotherapy and the pitfalls of the current pituitary tumors classification. To our knowledge, this case corresponds to one of the most aggressive pituitary neoplasms reported so far, with a very high Ki-67 index (75%) and short survival (2 months). Ki-67 index could be of prognostic value in pituitary tumors. Pituitary tumors World Health Organization (WHO) classification could be revisited.

scholarly journals Primary Hemangioblastoma of Kidney with Molecular Analyses by Next Generation Sequencing: A Case Report and Review of the Literature

2021 ◽  
Author(s):  
Xintong Wang ◽  
George K Haines ◽  
Jane Houldsworth ◽  
Qiusheng Si
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Renal Cell ◽  
Pathological Examination ◽  
Molecular Evidence ◽  
Pathologic Features ◽  
Eosinophilic Cytoplasm ◽  
The Central Nervous System ◽  
Positive Immunostaining ◽  
Vhl Disease

Abstract Background: Hemangioblastoma is an indolent mesenchymal tumor most frequently occurring in the central nervous system (CNS), but can also arise extraneuraxially, as part of von Hippel-Lindau (VHL) disease or in sporadic cases. Extraneuraxial hemangioblastomas (EH) occur outside the central nervous system. It includes tumors arising from the nervous paraneuraxial structures and visceral organs. Sporadic hemangioblastoma of the kidney, a rare subset of EH, is an under-recognized renal neoplasm. There have been only 25 cases described to date in the English language literature. We report herein one additional case in a patient without VHL disease.Case presentation: A 61 year old male presenting with gross hematuria was found to have a 3.5 cm renal mass at the lateral mid to lower pole of the left kidney on computed tomography urogram. Patient underwent a partial nephrectomy for the mass. The pathological examination showed a well-circumscribed non-encapsulated tumor composed of sheets of large polygonal cells traversed by a rich vascular network. The tumor cells showed clear to eosinophilic cytoplasm and overall bland nuclei. The diagnosis of hemangioblastoma was confirmed by positive immunostaining for alpha-inhibin, S100, neuron-specific enolase, PAX8, and negative staining for epithelial membrane antigen, HMB-45, and Melan-A. VHL gene mutation was not detected in this tumor. The diagnosis of sporadic renal hemangioblastoma was made.Conclusion: Sporadic renal hemangioblastoma (RH) is a rare subset of EH. We report herein one such case in a patient without clinical or molecular evidence of VHL disease. We reviewed the literature to better understand the clinical, radiological and pathologic features of this neoplasm. From our review cases and the present case, we have found that the majority of RHs showed a positive immunostaining for PAX8, which supports the idea that the immunoprofiles of EH can vary depending on sites of origin. Diagnosis of renal hemangioblastoma is challenging because of its rarity and overlapping microscopic and immunophenotypic features with renal cell tumor, especially with clear cell renal cell carcinoma. However, accurate diagnosis is necessary, since RH is clinically benign and correct recognition of this pathological entity is important to avoid unnecessary over treatment.

Primary central nervous system lymphoma in homosexual men. Clinical, immunologic, and pathologic features

1985 ◽  
Vol 78 (5) ◽  
pp. 742-748 ◽  
Author(s):  
Parkash S. Gill ◽  
Alexandra M. Levine ◽  
Paul R. Meyer ◽  
William D. Boswell ◽  
Ronald L. Burkes ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Lymphoma ◽  
Homosexual Men ◽  
Pathologic Features

scholarly journals A case report: venous sinus thrombosis in pregnancy

2017 ◽  
Vol 6 (10) ◽  
pp. 4721
Author(s):  
Abhilasha Singh ◽  
Smiti Nanda
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Presentation ◽  
Sinus Thrombosis ◽  
Sudden Onset ◽  
Venous Sinus ◽  
Radiological Investigation ◽  
Venous Sinus Thrombosis ◽  
Central Nervous System Disorders ◽  
In Pregnancy

Venous sinus thrombosis (VST) should be considered in the differential diagnosis of all unexplained central nervous system disorders of sudden onset. Etiological factors are subclinical forms of several common thrombophilic states occurring together, rather than the typical inherited and rare causes. Diagnosis is often missed because of the heterogeneity in clinical presentation and radiological investigation is essential for the diagnosis. Prognosis depends on the early detection. By correcting the cause, the complications can be prevented.

scholarly journals Patient with severe fever with thrombocytopenia syndrome virus infection and central nervous system disturbance in Dongyang, Zhejiang Province, China, 2017

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Yi Sun ◽  
Bin Guo ◽  
Hao Yan ◽  
Ai Lan Wu ◽  
Wen Wu Yao ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Laboratory Tests ◽  
Hemorrhagic Fever ◽  
Activated Partial Thromboplastin Time ◽  
Zhejiang Province ◽  
Case Presentation ◽  
First Case ◽  
Severe Fever ◽  
Elevated Lactate

Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SFTSV) infection, with a rapidly progressive central nervous system (CNS) disturbance, in Dongyang, Zhejiang Province, China, in 2017. Case presentation A 64-year-old man was admitted to hospital after 4 days of fever. SFTSV was detected 1 day after the patient was admitted to hospital. The patient presented with CNS disturbance and died 4 days after admission. Detailed clinical and epidemiological investigations and laboratory tests were conducted. Reduced platelet, white blood cell, lymphocyte, and neutrophil counts, elevated lactate dehydrogenase, creatine kinase, aspartate aminotransferaseand alanine aminotransferase concentrations, and an increased activated partial thromboplastin time were observed. In a phylogenetic analysis, the isolate clustered close to a strain derived from South Korea. Conclusions: This is the first case of SFTSV infection with CNS disturbance in Dongyang, Zhejiang Province, China. The surveillance of suspected cases of SFTS is important in SFTSV endemic regions.

scholarly journals Cerebral Epidural Abscess Secondary to Blastomyces Masquerading as an Epidermoid Tumor

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Cody Doberstein ◽  
Abass Noor ◽  
David Choi ◽  
Jacob Smith ◽  
Darren Groh ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Rhode Island ◽  
Endemic Area ◽  
Epidural Abscess ◽  
Blastomyces Dermatitidis ◽  
Unique Case ◽  
Epidermoid Tumor ◽  
Pathologic Features ◽  
History Of

Abstract There have been infrequent reports of isolated central nervous system blastomycosis. We report a case of intracranial epidural abscess secondary to Blastomyces dermatitidis in a patient residing in Rhode Island with a history of remote travel to an endemic area. The clinical, radiographic, and pathologic features of this unique case are reviewed.

scholarly journals Successful Removal of Cranial Migrated Intravitreal Perfluorocarbon through A Lumbar Puncture

2020 ◽  
Author(s):  
Lin Chen ◽  
Zhongheng Zhang ◽  
Qing Wang ◽  
Hongying Ni
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Extracorporeal Membrane Oxygenation ◽  
Lumbar Puncture ◽  
Subarachnoid Space ◽  
Sudden Onset ◽  
Neurogenic Pulmonary Edema ◽  
Ocular Surgery ◽  
Case Presentation ◽  
Successful Removal

Abstract Background: Perfluorocarbon migrating into subarachnoid was very rare let alone its further removing from central nervous system. Case presentation: We report a case of migration of intravitreal perfluorocarbon into cranial space and further removed through a lumbar puncture treatment. The patient showed a sudden onset of hypoxemia and hypotension during an ocular surgery, which was highly suspected as neurogenic pulmonary edema caused by the migrated perfluorocarbon. The patient's symptoms improved after extracorporeal membrane oxygenation (ECMO). The perfluorocarbon gradually descended through subarachnoid space to lumbar cisterna and finally drained by a lumbar puncture. Conclusions: Perfluorocarbon could enter the cranial space during ocular surgery and threaten the life of patient. Further migrating through subarachnoid space provide the opportunity to remove it.

Sign in / Sign up

Export Citation Format

Share Document