Relation of Vitamin D Deficiency to Cardiovascular Risk Factors, Disease Status, and Incident Events in a General Healthcare Population

Based on a nationally representative sample of young Mexican women aged 20 to 49 years (n = 3260), we sought to explore whether cardiovascular risk factors and acute myocardial infarction (AMI) were associated with vitamin D deficiency (VDD, defined as 25-OH-D <50 nmol/L). To this end, we obtained sociodemographic, serum and anthropometric data from the 2012 National Health and Nutrition Survey (ENSANUT 2012). Analyses were developed through logistic regression models adjusted for potential confounders. The prevalence of VDD was significantly higher in obese women (42.5%, 95% CI; 37.3–47.9) compared to women with a normal body mass index (29.9%, 95% CI; 23.5–37.1, p = 0.05), in those with high total cholesterol (TC) (45.6% 95% CI; 39.4–51.9) compared to those with normal TC levels (33.9%, 95% CI 30–38.1, p = 0.03), and in those with insulin resistance (IR) (44%, 95% CI; 36.9–51.7) or type 2 diabetes mellitus (T2DM) (58.6%, 95% CI 46.9–69.4) compared to those with normal glycemia (no insulin resistance: 34.7%, 95% CI; 30.9–38.8, p = 0.04 and no T2DM: 34.9%, 95% CI 31.4–38.6, p < 0.001). Utilizing individual models to estimate cardiovascular risk according to VDD, we found that the odds of being obese (odds ratio, OR: 1.53, 95% CI 1.02–2.32, p = 0.05), or having high TC levels (OR: 1.43, 95% CI; 1.05–2.01, p = 0.03), T2DM (OR: 2.64, 95% CI; 1.65–4.03, p < 0.001), or IR (OR: 1.48, 95% CI 1.04–2.10, p = 0.026) were significantly higher in women with VDD (p < 0.05). Odds were not statistically significant for overweight, high blood pressure, sedentarism, AMI, high serum concentration of triglycerides, homocysteine, or C-reactive protein models. In conclusion, our results indicate that young Mexican women with VDD show a higher prevalence of cardiovascular risk factors.

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Effect of one-anastomosis gastric bypass on cardiovascular risk factors in patients with vitamin D deficiency and morbid obesity: A secondary analysis

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2020.08.011 ◽

2020 ◽

Vol 30 (12) ◽

pp. 2379-2388

Author(s):

Renate Kruschitz ◽

Maria Wakolbinger ◽

Karin Schindler ◽

Gerhard Prager ◽

Friedrich Hoppichler ◽

...

Keyword(s):

Risk Factors ◽

Morbid Obesity ◽

Vitamin D ◽

Gastric Bypass ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Vitamin D Deficiency ◽

Secondary Analysis ◽

One Anastomosis Gastric Bypass

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Abstract 121: Relationship of Vitamin D Level with Cardiovascular Fitness: Does Demography Matter?

Circulation Cardiovascular Quality and Outcomes ◽

10.1161/circoutcomes.5.suppl_1.a121 ◽

2012 ◽

Vol 5 (suppl_1) ◽

Author(s):

Hemang B Panchal ◽

Saurabh Desai ◽

Tejaskumar Shah ◽

Rakeshkumar Patel ◽

Vijay Ramu

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Young Adults ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Vitamin D Deficiency ◽

Cardiovascular Fitness ◽

Normal Vitamin ◽

Relationship Of ◽

The Relationship

Background: Recent studies have suggested association of vitamin D with cardiovascular events. The relationship of vitamin D deficiency with cardiovascular fitness level (CVF) has not been studied in current literatures. Demographic variation of this association is also unclear. The primary objective of our study was to assess the relationship of vitamin D level to CVF and evaluate the demographic variation of this association in young adults. The secondary objective of this study was to assess the relationship of vitamin D level with the other cardiovascular risk factors. Methods: We evaluated 5388 adults from National Health and Nutrition Examination Survey 2001-2004. The associations of serum 25-hydroxy vitamin D level with CVF and cardiovascular risk factors such as systolic/diastolic blood pressure (SBP/DBP), low density lipoprotein (LDL), high density lipoprotein (HDL), and glycohemoglobin (HbA1c) levels in young adults aged 20-49 years were evaluated. Adults with vitamin D deficiency (≤30 mg/dL) and normal vitamin D level (>30 mg/dL) were compared. The CVF was assessed with peak oxygen uptake on treadmill test (VO2 max <20 percentile= low CVF, VO2 max ≥60 percentile= high CVF). Chi square analysis and odds ratio were calculated to assess the association of vitamin D deficiency with CVF. Pearson correlation was measured for the secondary analysis of association of vitamin D level with cardiovascular risk factors. The alpha error ≤0.05 was used as a level of significance. Results: Total of 85.4% (n=4603/5388) young adults had vitamin D deficiency. Vitamin D level was positively associated with CVF (p<0.001). In comparison to normal vitamin D level, vitamin D deficiency was significantly associated with low CVF (Odds ratio 2.01, confidence interval 1.64-2.46, p<0.001). In contrast to normal vitamin D level, vitamin D deficiency was significantly associated with low CVF in subgroups of males (p<0.01), females (p<0.01), age group of 20-29 years (p<0.01) and age group of 30-49 years (p<0.01). In contrast to normal vitamin D level, vitamin D deficiency was significantly associated with low CVF only in Caucasians (p=0.001). This association was not significant in Mexican-Hispanics (p=0.35), other Hispanics (p=0.095), African Americans (p=0.061) and other races (p=0.206). In comparison to normal vitamin D level, vitamin D deficiency was significantly associated with low CVF among normal BMI (p<0.001), overweight BMI (p<0.001) and obese adults (p=0.019) but not in underweight BMI adults (p=0.48). Vitamin D level was inversely associated with SBP (p<0.001), and HbA1c (p<0.001) and positively associated with HDL (p<0.001). There was no significant association found between vitamin D level and DBP (p=0.66) or LDL (p=0.79). Conclusions: The results of our study demonstrate that vitamin D deficiency may decrease CVF in Caucasian young adults. Surprisingly it may not affect CVF in other races and underweight adults. Vitamin D deficiency is also associated with increase in cardiovascular risk factors such as low HDL, high SBP and HbA1c. The large population based clinical trials are needed for evaluation of this relationship and long-term consequences on cardiovascular outcomes.

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VITAMIN D DEFICIENCY IN PATIENTS WITH ACUTE CORONARY SYNDROME

Complex Issues of Cardiovascular Diseases ◽

10.17802/2306-1278-2019-8-2-12-20 ◽

2019 ◽

Vol 8 (2) ◽

pp. 12-20

Author(s):

R. S. Bogachev ◽

L. V. Mikhailova ◽

E. S. Shytova ◽

V. V. Mordvincev ◽

V. Ankudovich ◽

...

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Acute Coronary Syndrome ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Vitamin D Deficiency ◽

Left Ventricular ◽

Total Serum ◽

Coronary Syndrome ◽

Vitamin D Levels

Aim. To assess vitamin D level in patients with acute coronary syndrome and to determine the relationships of vitamin D level with specific patterns of cardiovascular disease in this group of patients.Methods. 50 patients (35 (70%) males and 15 (30%) females) urgently admitted to the emergency cardiology department of Kaliningrad Regional Hospital were enrolled in the cross-sectional observational study. Patients with diabetes mellitus, autoimmune diseases and cancer were excluded from the study. The mean age of patients was 60 (55; 66) years. Cardiovascular risk factors (obesity, smoking, physical activity, alcohol consumption, genetic predisposition) were assessed in all patients. Total serum cholesterol levels, GFR (CKD-EPI) and troponin levels were measured in all participants. Echocardiography included the measurement of the left ventricular mass index. Coronary angiography with omnipaque contrast was performed in all cases. 25-OH vitamin D was measured with enzyme-linked immunosorbent assay (ELISA).Results. The majority of patients with acute coronary syndrome had vitamin D deficiency. 3 (6%) patients had severe vitamin D deficiency. The subgroup of patients with marked vitamin D deficiency (n = 39) more often had elevated blood pressure probably related to the left ventricular hypertrophy and left atrial enlargement. Left ventricular systolic dysfunction and occlusive coronary artery disease were more common in patients with lower vitamin D levels. Statistically significant correlations had not been found between vitamin D levels and cardiovascular risk factors as well as laboratory data.Conclusion. Vitamin D level below normal range was detected in the vast majority of patients with acute coronary syndrome, of them 6 % of patients had critically low vitamin D levels.

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