Follicular thyroid cancer in a patient with Pendred syndrome

Differentiated thyroid cancer (DTC) patients are usually known for their excellent prognoses. However, some patients with DTC develop refractory disease and require novel therapies with different therapeutic mechanisms. Targeting Wee1 with adavosertib has emerged as a novel strategy for cancer therapy. We determined the effects of adavosertib in four DTC cell lines. Adavosertib induces cell growth inhibition in a dose-dependent fashion. Cell cycle analyses revealed that cells were accumulated in the G2/M phase and apoptosis was induced by adavosertib in the four DTC tumor cell lines. The sensitivity of adavosertib correlated with baseline Wee1 expression. In vivo studies showed that adavosertib significantly inhibited the xenograft growth of papillary and follicular thyroid cancer tumor models. Adavosertib therapy, combined with dabrafenib and trametinib, had strong synergism in vitro, and revealed robust tumor growth suppression in vivo in a xenograft model of papillary thyroid cancer harboring mutant BRAFV600E, without appreciable toxicity. Furthermore, combination of adavosertib with lenvatinib was more effective than either agent alone in a xenograft model of follicular thyroid cancer. These results show that adavosertib has the potential in treating DTC.

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Clonally Related But Phenotypically Divergent Human Cancer Cell Lines Derived from a Single Follicular Thyroid Cancer Recurrence (TT2609)

Thyroid ◽

10.1089/105072501753210966 ◽

2001 ◽

Vol 11 (10) ◽

pp. 909-917 ◽

Cited By ~ 11

Author(s):

Albert A. Geldof ◽

Richard T. Versteegh ◽

Johan C. van Mourik ◽

Martin A. Rooimans ◽

Fre Arwert ◽

...

Keyword(s):

Thyroid Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Human Cancer ◽

Cancer Recurrence ◽

Cancer Cell Lines ◽

Human Cancer Cell ◽

Follicular Thyroid Cancer ◽

Human Cancer Cell Lines ◽

Thyroid Cancer Recurrence

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INFORMATIVE VALUE OF SONOELASTOGRAPHY IN THE DIFFERENTIAL DIAGNOSIS OF FOLLICULAR THYROID CANCER

Acta medica Eurasica ◽

10.47026/2413-4864-2021-4-73-78 ◽

2021 ◽

pp. 73-78

Author(s):

Lyubov A. Timofeeva ◽

Tatiana N. Aleshina ◽

Marina E. Baranova ◽

Marina A. Yusova ◽

Natalia N. Nikolaeva

Keyword(s):

Thyroid Cancer ◽

Preoperative Diagnosis ◽

Surgical Intervention ◽

Ultrasound Examination ◽

Shear Wave Elastography ◽

Diagnostic Methods ◽

Follicular Thyroid Cancer ◽

Leading Role ◽

Quantitative Characteristics ◽

Multiparametric Ultrasound

In recent years, the opportunities of radiation diagnostic methods have stepped far ahead and today they play a leading role at the stage of preoperative diagnosis of thyroid diseases. The most promising of them is multiparametric ultrasound examination, as well as sonoelastography associated with it. Strain elastography and shear wave elastography make it possible to determine the boundaries of pathological formation and quantitative characteristics of nodular stiffness, which is important when determining the boundaries of invasive tumor growth, primarily thyroid cancer, when planning an upcoming surgical intervention. The article describes a clinical case of radiation diagnosis made for follicular thyroid cancer; it shows the importance of multiparametric ultrasound, including sonoelastography, in the early detection of thyroid cancer. A timely diagnosis and a correct chosen tactics for treating follicular thyroid cancer resulted in a favorable disease outcome.

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