Effects of commercial dietary prebiotic and probiotic supplements on growth, innate immune responses, and intestinal microbiota and histology of Totoaba macdonaldi

Aquaculture ◽  
2018 ◽  
Vol 491 ◽  
pp. 239-251 ◽  
Author(s):  
Mayra L. González-Félix ◽  
Delbert M. Gatlin ◽  
Perla Urquidez-Bejarano ◽  
Carolina de la Reé-Rodríguez ◽  
Lyra Duarte-Rodríguez ◽  
...  
Keyword(s):  
Immune Responses ◽  
Intestinal Microbiota ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Totoaba Macdonaldi

scholarly journals Rifaximin prevents ethanol-induced liver injury in obese KK-Ay mice through modulation of small intestinal microbiota signature

2019 ◽  
Vol 317 (5) ◽  
pp. G707-G715 ◽  
Author(s):  
Ryuta Kitagawa ◽  
Kazuyoshi Kon ◽  
Akira Uchiyama ◽  
Kumiko Arai ◽  
Shunhei Yamashina ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Immune Responses ◽  
Intestinal Microbiota ◽  
Innate Immune ◽  
Mrna Levels ◽  
Innate Immune Responses ◽  
Toll Like Receptor ◽  
Small Intestinal ◽  
Cluster Of Differentiation ◽  
Binge Ethanol

Exacerbation of alcoholic hepatitis (AH) with comorbid metabolic syndrome is an emerging clinical problem, where microbiota plays a profound role in the pathogenesis. Here, we investigated the effect of rifaximin (RFX) on liver injury following chronic-binge ethanol (EtOH) administration in KK-Ay mice, a rodent model of metabolic syndrome. Female, 8-wk-old KK-Ay mice were fed Lieber–DeCarli diet (5% EtOH) for 10 days, following a single EtOH gavage (4 g/kg body wt). Some mice were given RFX (0.1 g/L, in liquid diet) orally. Small intestinal contents were collected from mice without binge. Intestinal microbiota was quantified using aerobic and anaerobic culturing techniques and further analyzed by 16S rRNA sequencing in detail. EtOH feeding/binge caused hepatic steatosis, oxidative stress, and induction of inflammatory cytokines in KK-Ay mice, which were markedly prevented by RFX treatment. Hepatic mRNA levels for cluster of differentiation 14, Toll-like receptor (TLR) 4, TLR2, and NADPH oxidase 2 were increased following EtOH feeding/binge, and administration of RFX completely suppressed their increase. The net amount of small intestinal bacteria was increased over threefold after chronic EtOH feeding as expected; however, RFX did not prevent this net increase. Intriguingly, the profile of small intestinal microbiota was dramatically changed following EtOH feeding in the order level, where the Erysipelotrichales predominated in the relative abundance. In sharp contrast, RFX drastically blunted the EtOH-induced increases in the Erysipelotrichales almost completely, with increased proportion of the Bacteroidales. In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-Ay mice. NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-Ay mice. Chronic EtOH feeding caused small intestinal bacterial overgrowth, with drastic alteration in the microbiota profile predominating the order Erysipelotrichales. RFX minimized this EtOH induction in Erysipelotrichales with substitutive increases in Bacteroidales. RFX also prevented EtOH-induced increases in portal lipopolysaccharide, and hepatic cluster of differentiation 14, toll-like receptor (TLR) 2, and TLR4 mRNA levels, suggesting the potential involvement of microbiota-related innate immune responses.

Pathogen invasion changes the intestinal microbiota composition and induces innate immune responses in the zebrafish intestine

2017 ◽  
Vol 71 ◽  
pp. 35-42 ◽  
Author(s):  
Hui-Ting Yang ◽  
Song-Song Zou ◽  
Li-Juan Zhai ◽  
Yao Wang ◽  
Fu-Miao Zhang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Intestinal Microbiota ◽  
Innate Immune ◽  
Microbiota Composition ◽  
Innate Immune Responses ◽  
Pathogen Invasion

scholarly journals Fecal transplantation does not transfer either susceptibility or resistance to food borne listeriosis in C57BL/6 and BALB/c/By mice

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 177 ◽  
Author(s):  
Tanya Myers-Morales ◽  
Kate M Bussell ◽  
Sarah EF D'Orazio
Keyword(s):  
Gut Microbiota ◽  
Immune Responses ◽  
Intestinal Microbiota ◽  
Innate Immune ◽  
Microbiota Composition ◽  
Innate Immune Responses ◽  
Fecal Matter ◽  
Fecal Transplantation ◽  
Food Borne ◽  
Key Factor

The composition of the intestinal microbiota has wide reaching effects on the health of an individual, including the development of protective innate immune responses.  In this report, a fecal transplantation approach was used to determine whether resistance to food borne listeriosis was dependent on the murine gut microbiota.  Transplantation of BALB/c/By feces did not increase the susceptibility of C57BL/6 mice to Listeria monocytogenes infection.   Likewise, transplantation of C57BL/6 fecal matter did not enhance the resistance of BALB/c/By mice.  Thus, intestinal microbiota composition is not a key factor that confers either susceptibility or resistance to food borne listeriosis in mice.

Oral Immune Activation by Disgust and Disease-Related Pictures

2015 ◽  
Vol 29 (3) ◽  
pp. 119-129 ◽  
Author(s):  
Richard J. Stevenson ◽  
Deborah Hodgson ◽  
Megan J. Oaten ◽  
Luba Sominsky ◽  
Mehmet Mahmut ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Innate Immune Response ◽  
Negative Control ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Markers ◽  
Before And After ◽  
Secondary Analyses ◽  
Image Set

Abstract. Both disgust and disease-related images appear able to induce an innate immune response but it is unclear whether these effects are independent or rely upon a common shared factor (e.g., disgust or disease-related cognitions). In this study we directly compared these two inductions using specifically generated sets of images. One set was disease-related but evoked little disgust, while the other set was disgust evoking but with less disease-relatedness. These two image sets were then compared to a third set, a negative control condition. Using a wholly within-subject design, participants viewed one image set per week, and provided saliva samples, before and after each viewing occasion, which were later analyzed for innate immune markers. We found that both the disease related and disgust images, relative to the negative control images, were not able to generate an innate immune response. However, secondary analyses revealed innate immune responses in participants with greater propensity to feel disgust following exposure to disease-related and disgusting images. These findings suggest that disgust images relatively free of disease-related themes, and disease-related images relatively free of disgust may be suboptimal cues for generating an innate immune response. Not only may this explain why disgust propensity mediates these effects, it may also imply a common pathway.

Innate immune responses and type 1 diabetes: A role for a long non-coding RNA?

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
MP Ashton ◽  
I Tan ◽  
L Mackin ◽  
C Elso ◽  
E Chu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Modulation of Innate Immune Responses by Hantaviruses

2010 ◽  
Vol 30 (6) ◽  
pp. 515-527 ◽  
Author(s):  
Andreas Rang
Keyword(s):  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses
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