The role of egocentric and allocentric abilities in Alzheimer's disease: A systematic review

2014 ◽  
Vol 16 ◽  
pp. 32-44 ◽  
Author(s):  
Silvia Serino ◽  
Pietro Cipresso ◽  
Francesca Morganti ◽  
Giuseppe Riva
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease

scholarly journals A Systematic Review and Meta-Analysis of the Role of Toll-Like Receptor 9 in Alzheimer’s Disease: The Protocol for a Systematic Review

Thrita ◽  
2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Nasrin Hosseini ◽  
Shabnam Nadjafi ◽  
Leila Janani ◽  
Zahra Faraji ◽  
Behnaz Ashtari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Search Strategy ◽  
Web Of Science ◽  
Meta Analysis ◽  
Toll Like Receptor ◽  
Therapeutic Tools ◽  
Meta Analyses

Context: Alzheimer’s disease (AD) is a neurodegenerative disease affecting many people around the world. Recently, it has been reported that toll-like receptors (TLRs) play a role in AD; therefore, the present study aimed to systematically review the studies and to meta-analyze the role of toll-like receptor 9 (TLR9) in AD. Methods: Seven main electronic databases, including PubMed/MEDLINE, Web of Science, Embase, Scopus, CINAHL, Cochrane, and Google Scholar, will be considered with no language restrictions. Full texts of articles will be prepared by a determined search strategy. Studies including the assessment of TLR9 function in adults with AD, published before June 15 2020, will be considered. Hence, this protocol will be presented based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statements for protocols. The related results and data analyses will be provided in the final review. This paper plans the protocol for a systematic review identifying TLR9 up-regulation and down-regulation in adults with AD. Conclusions: The meta-analysis of TLR9 may subsequently provide attractive therapeutic tools for AD.

Systematic review by meta-analyses on the possible role of TNF-α polymorphisms in association with Alzheimer's disease

2009 ◽  
Vol 61 (2) ◽  
pp. 60-68 ◽  
Author(s):  
Danilo Di Bona ◽  
Giuseppina Candore ◽  
Claudio Franceschi ◽  
Federico Licastro ◽  
Giuseppina Colonna-Romano ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tnf Α ◽  
Meta Analyses

scholarly journals Systematic review of the literature on vitamin A and memory

2012 ◽  
Vol 6 (4) ◽  
pp. 219-222 ◽  
Author(s):  
Yara Dadalti Fragoso ◽  
Niklas Söderberg Campos ◽  
Breno Faria Tenrreiro ◽  
Fernanda Jussio Guillen
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vitamin A ◽  
Evidence Based ◽  
Review Of The Literature ◽  
Vitamin A Supplementation ◽  
Treatment And Prevention ◽  
The Subject

ABSTRACT Background: Over the last 30 years, a variety of studies reporting the effects of vitamin A on memory have been published. Objective: To perform a rigorous systematic review of the literature on vitamin A and memory in order to organize evidence-based data on the subject. Methods: Four authors carried out the systematic review in accordance with strict guidelines. The terms "vitamin A" OR "retinol" OR "retinoic acid" AND "memory" OR "cognition" OR "Alzheimer" were searched in virtually all medical research databases. Results: From 236 studies containing the key words, 44 were selected for this review, numbering 10 reviews and 34 original articles. Most studies used animal models for studying vitamin A and cognition. Birds, mice and rats were more frequently employed whereas human studies accounted for only two reports on brain tissue from autopsies and one on the role of isotretinoin in cognition among individuals taking this medication to treat acne. Conclusion: Vitamin A may be an important and viable complement in the treatment and prevention of Alzheimer's disease. Clinical trials are imperative and, at present, there is no evidence-based data to recommend vitamin A supplementation for the prevention or treatment of Alzheimer's disease.

The role of nutrients in the prevention and treatment of Alzheimer’s disease: methodology for a systematic review

2009 ◽  
Vol 16 ◽  
pp. 8-11 ◽  
Author(s):  
D. R. George ◽  
A. D. Dangour ◽  
L. Smith ◽  
J. Ruddick ◽  
B. Vellas ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prevention And Treatment

Systematic review and meta-analysis on the role of mitochondrial cytochrome c oxidase in Alzheimer’s disease

2020 ◽  
pp. 1-10
Author(s):  
Flavio M. Morais ◽  
Angela M. Ribeiro ◽  
Fabricio A. Moreira ◽  
Pollyanna V. G. Silva
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cytochrome C ◽  
Cytochrome C Oxidase ◽  
Meta Analysis ◽  
Treatment Target ◽  
Complex Iv ◽  
New Treatment

Abstract Objective: The present study was designed to test the hypothesis that there is a reduction in the activity of the enzyme cytochrome c oxidase (Cox) in Alzheimer’s disease (AD). Methods: Systematic review of literature and meta-analysis were used with data obtained from the PubMed, Scopus, MEDLINE, Lilacs, Eric and Cochrane. The keywords were Alzheimer’s AND Cox AND mitochondria; Alzheimer’s AND Cox AND mitochondria; Alzheimer’s AND complex IV AND mitochondria. A total of 1372 articles were found, 23 of them fitting the inclusion criteria. The data were assembled in an Excel spreadsheet and analysed using the RevMan software. A random effects model was adopted to the estimative of the effect. Results: The data shows a significant decrease in the activity of the Cox AD patients and animal models. Conclusion: Cox enzyme may be an important molecular component involved in the mechanisms underlying AD. Therefore, this enzyme may represent a possible new biomarker for the disease as a complementary diagnosis and a new treatment target for AD.

Dissecting the role of Corticotropin-releasing hormone receptor type 1 in Alzheimer's Disease

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
K Lerche ◽  
M Willem ◽  
K Kleinknecht ◽  
C Romberg ◽  
U Konietzko ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Hormone Receptor ◽  
Receptor Type ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone

Role of melatonin in regulating neurogenesis: Implications for the neurodegenerative pathology and analogous therapeutics for Alzheimer’s disease

2020 ◽  
Vol 3 (2) ◽  
pp. 216-242 ◽  
Author(s):  
Mayuri Shukla ◽  
Areechun Sotthibundhu ◽  
Piyarat Govitrapong
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Adult Neurogenesis ◽  
Adult Brain ◽  
Therapeutic Approaches ◽  
Therapeutic Implications ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Progenitor Cell Proliferation

The revelation of adult brain exhibiting neurogenesis has established that the brain possesses great plasticity and that neurons could be spawned in the neurogenic zones where hippocampal adult neurogenesis attributes to learning and memory processes. With strong implications in brain functional homeostasis, aging and cognition, various aspects of adult neurogenesis reveal exuberant mechanistic associations thereby further aiding in facilitating the therapeutic approaches regarding the development of neurodegenerative processes in Alzheimer’s Disease (AD). Impaired neurogenesis has been significantly evident in AD with compromised hippocampal function and cognitive deficits. Melatonin the pineal indolamine augments neurogenesis and has been linked to AD development as its levels are compromised with disease progression. Here, in this review, we discuss and appraise the mechanisms via which melatonin regulates neurogenesis in pathophysiological conditions which would unravel the molecular basis in such conditions and its role in endogenous brain repair. Also, its components as key regulators of neural stem and progenitor cell proliferation and differentiation in the embryonic and adult brain would aid in accentuating the therapeutic implications of this indoleamine in line of prevention and treatment of AD.   

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