Association between serum C-reactive protein levels and pulse wave velocity: a population-based cross-sectional study in a general population

2005 ◽  
Vol 180 (1) ◽  
pp. 189-195 ◽  
Author(s):  
Masahide Nagano ◽  
Motoyuki Nakamura ◽  
Kenyu Sato ◽  
Fumitaka Tanaka ◽  
Toshie Segawa ◽  
...  
2004 ◽  
Vol 43 (10) ◽  
pp. 919-925 ◽  
Author(s):  
Motoyuki NAKAMURA ◽  
Toshiyuki ONODA ◽  
Kazuyoshi ITAI ◽  
Masaki OHSAWA ◽  
Kenyu SATOU ◽  
...  

2021 ◽  
Vol 11 (12) ◽  
pp. 1278
Author(s):  
Kyi Mar Wai ◽  
Sawada Kaori ◽  
Ken Itoh ◽  
Okuyama Shinya ◽  
Yuka Uchikawa ◽  
...  

Telomere (TL) is a biomarker of biological aging, and its shortening is associated with major risk factors for cardiovascular diseases (CVD). This study aimed to identify whether TL is associated with arterial stiffness as reflected by brachial–ankle pulse wave velocity (baPWV). This population-based cross-sectional study involved 1065 individuals in the Iwaki area, Japan. Total TL length and TL G-tail length were measured by hybridization protection assay. The baPWV was measured on the right and left sides using a non-invasive vascular screening device. The associations between TL and baPWV were assessed by multivariate linear regression. Compared with the shortest total TL tertile, the longest total TL group showed a significant decrease in baPWV (lowest vs. highest tertile: adjusted beta: −41.24, 95% confidence interval (CI): −76.81, −5.68). The mean baPWV decreased with a longer TL (TL G-tail length: p trend < 0.001, total TL: p trend < 0.001). TL G-tail and total TL lengths were inversely associated with baPWV, implicating TL shortening in the development of CVD. This study provides evidence of the factors influencing CVD risks at a very early stage when individuals can still take necessary precautions before CVD gives rise to a symptomatic health outcome.


2012 ◽  
Vol 52 (3) ◽  
pp. 161
Author(s):  
Ni Putu Sucita Wahyu Dewi ◽  
Putu Siadi Purniti ◽  
Roni Naning

Background Pneumonia is a major cause of death in children fromdeveloping countries. It is difficult to assess pneumonia severity ifclinical symptoms of pneumonia are unclear, co-morbidities occursimultaneously, or there is an absence of consolidation or infiltrateson chest radiograph. Examination of C-reactive protein (CRP)levels can help to determine the severity of pneumonia.Objective To compare serum CRP levels in severe and very severepneumonia cases.Methods This was a cross-sectional study on pediatric patientsaged> 28 days up to 60 months v.ith a diagnosis of severe or verysevere pneumonia. Subjects were hospitalized at the Departmentof Child Health, Udayana University Medical SchooliSanglahHospital, Denpasar from May 2010 to January 2011. There were30 subjects in each group, severe or very severe pneumonia. Datawere analyzed using Mann-Whitney and ANCOVA tests withstatistical significance set at P < 0.05.Results There were significant differences in median serum CRPlevels in the severe and very severe pneumonia groups. The verysevere pneumonia group had a median CRP level of 54.75 mgiL(lQrange 0.22 to 216.00) and the severe pneumonia group had amedian CRP level ofl6.06 mgiL (IQ range 0.97 to 89.35). SerumCRP levels were influenced by the severity of pneumonia (P =0.002) and the timing of the CRP examination (P = 0.001).Conclusion Subjects with very severe pneumonia hadsignificantly higher median CRP level compared to that of subjectswith severe pneumonia. [Paediatr Indones. 2012;52:161A].


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