Reduced testosterone levels are related to impaired metabolic profile, smaller HDL and LDL subfractions and enhanced inflammation and leukocyte-endothelium interactions in type 2 diabetic men

2018 ◽  
Vol 275 ◽  
pp. e198
Author(s):  
S. Rovira-llopis ◽  
C. Bañuls ◽  
N. Diaz-Morales ◽  
I. Escribano-Lopez ◽  
S. Lopez-Domenech ◽  
...  
Keyword(s):  
Metabolic Profile ◽  
Testosterone Levels ◽  
Ldl Subfractions ◽  
Type 2 Diabetic

scholarly journals Glyco-metabolic profile among type 2 diabetic patients with erectile dysfunction

2012 ◽  
Vol 59 (7) ◽  
pp. 611-619 ◽  
Author(s):  
Giuseppe Derosa ◽  
Carmine Tinelli ◽  
Angela D^|^rsquo;Angelo ◽  
Gianluca Ferrara ◽  
Aldo Bonaventura ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Metabolic Profile ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

scholarly journals Correlation of Adiponectin With Testosterone in Patients With and Without Type 2 Diabetes and Erectile Dysfunction

2018 ◽  
Vol 13 (1) ◽  
pp. 155798831880704
Author(s):  
Moustafa A. Elsaied ◽  
Doaa Masallat ◽  
Ibrahim A. Abdel-Hamid
Keyword(s):  
Insulin Resistance ◽  
Erectile Dysfunction ◽  
Fasting Blood Glucose ◽  
Total Testosterone ◽  
Diabetic Patients ◽  
Fasting Insulin ◽  
Type 2 Diabetic Patients ◽  
Testosterone Levels ◽  
Type 2 Diabetic

The aim of this study was to evaluate the levels of adiponectin in diabetic patients with and without erectile dysfunction (ED). In addition, the correlations of adiponectin with the scores of international index of erectile function (IIEF) and total testosterone levels were explored in diabetic and nondiabetic patients with ED. The study included three groups: Type 2 Diabetic patients (T2DM) with and without ED and a third nondiabetics with ED group, each of 29 patients. Fasting blood glucose (FBG), fasting insulin (FI), homeostasis model assessments of insulin resistance (HOMA-IR index), testosterone and adiponectin levels were evaluated. IIEF was applied to diabetic and nondiabetic patients with ED. The results showed that adiponectin was lower in diabetic patients with ED than in both nondiabetics with ED and diabetics without ED groups (5.23 ± 1.05 vs. 11.38 ± 10.08 and 6.5 ± 2.13; p = .003 and .006 respectively). Testosterone was lower in diabetic patients with ED than in diabetics without ED group (2.52 ± 1.15 vs. 4.1 ± 1.46; p = .024). Testosterone had a direct correlation with adiponectin ( r = .371; p = .001). Both adiponectin and testosterone levels did not correlate with IIEF. In conclusion, the decreased adiponectin and testosterone are associated with ED in T2DM. Testosterone has a direct correlation with circulating adiponectin while both have no correlation with IIEF.

scholarly journals Estimation of serum testosterone concentration in type 2 diabetic males

2020 ◽  
Vol 7 (2) ◽  
pp. 226
Author(s):  
Satya Bhushan Nayyar ◽  
Karamvir Singh ◽  
Neha .
Keyword(s):  
Serum Testosterone ◽  
Free Testosterone ◽  
Significant Negative Correlation ◽  
Total Testosterone ◽  
Control Groups ◽  
Testosterone Levels ◽  
High Incidence ◽  
And Control ◽  
Type 2 Diabetic

Background: A high incidence of hypogonadism in men with Type 2 Diabetes Mellitus has been globally reported. The present study was aimed at determining the frequency of hypogonadism in T2DM males. Screening and management of hypogonadism in Diabetic males should be done.Methods: In this case control study conducted from January 2018 to August 2019 at SGRDIMSR Sri Amritsar 100 Type 2 Diabetic males were taken as cases. 50 age matched nondiabetic males were taken as controls. Apart from BMI and waist hip ratio routine investigations, HbA1C, serum total and free testosterone levels were done. All the subjects were subjected to ADAM questionnaire to evaluate for hypogonadism.Results: Majority of subjects were in the age of 40-50 years. Mean Serum Total Testosterone levels in Study and Control Groups were 4.94±5.32 nmol/L and 6.63±4.54 nmol/L respectively (p=0.045). Mean Serum Free Testosterone levels in Study and Control Groups were 4.12±3.43 pg/ml and 6.05±3.24 pg/ml respectively (p=0.001). A statistically highly significant negative correlation was found between BMI and Serum Testosterone levels in both groups. Prevalence of hypogonadism (Total Testosterone <4.56 nmol/L) in Study and Control Groups was 73% and 58% respectively. Sensitivity and specificity of ADAM questionnaire was found to be 78.46% and 94.29 % respectively.Conclusions: Prevalence of hypogonadism among T2DM males is high. So, screening for hypogonadism should be done. ADAM questionnaire can be used as a screening tool, results must be confirmed with Serum Total Testosterone levels.

Testosterone Levels in Type 1 Diabetic, Type 2 Diabetic and Non-Diabetic Men

2011 ◽  
pp. P3-480-P3-480
Author(s):  
Mark Ng Tang Fui ◽  
Phuong Nguyen ◽  
Emily J Giannatti ◽  
Jeffrey D Zajac ◽  
Mathis Grossmann
Keyword(s):  
Diabetic Type ◽  
Testosterone Levels ◽  
Type 2 Diabetic

scholarly journals Clinical and Biochemical Assessment of Hypogonadism in Type 2 Diabetic Men

2012 ◽  
Vol 1 (1) ◽  
pp. 3-9
Author(s):  
SK Talukder ◽  
F Afsana ◽  
ZA Latif ◽  
F Pathan ◽  
SM Ashrafuzzaman ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Hypogonadotropic Hypogonadism ◽  
Serum Testosterone ◽  
Total Testosterone ◽  
Testosterone Levels ◽  
High Prevalence ◽  
D 12 ◽  
Type 2 Diabetic ◽  
Low Serum

doiAim: The aim of the study was to assess the prevalence of clinical hypogonadism in type 2 diabetic men based on clinical features and available biochemical measures. Materials and Methods: In this study carried out in a tertiary level hospital, serum concentration of total testosterone was measured in 170 type 2 diabetic (mean age 44.9±7.9 years) subjects who have erectile dysfunction or other features of hypogonadism. Results: The mean total testosterone concentration in type 2 diabetic men was 14.4±5.6 nmol/l. Fifty nine of 170 (34.7%) type 2 diabetic subjects had low serum testosterone levels (d”12 nmol/L). Luteinizing hormone (LH) and follicle stimulating hormone (FSH) concentrations in type 2 diabetic men were inappropriately low with a very high prevalence of hypogonadotropic hypogonadism. BMI and waist circumference were both negatively correlated with testosterone levels, with the association being stronger for waist circumference. HbA1C level also reveal a negative association with sexual dysfunction and hypogonadotropic hypogonadism among type 2 diabetic men. Metabolic syndrome is also associated with the low serum testosterone levels in the study subjects. Conclusions: This study reveals that serum total testosterone levels are lower in diabetic men with signs/symptoms of hypogonadism. Hypogonadotropic hypogonadism is frequent in diabetic hypogondal population. There is an association between poor glycaemic control and hypogonadism in male diabetic persons. DOI: http://dx.doi.org/10.3329/birdem.v1i1.12378 Birdem Med J 2011; 1(1): 3-9

scholarly journals Prevalence and determinants of low testosterone levels in men with type 2 diabetes mellitus; a case-control study in a district hospital in Ghana

2021 ◽  
Vol 1 (12) ◽  
pp. e0000052
Author(s):  
Dorcas Serwaa ◽  
Folasade Adenike Bello ◽  
Kayode O. Osungbade ◽  
Charles Nkansah ◽  
Felix Osei-Boakye ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Case Control Study ◽  
District Hospital ◽  
Case Control ◽  
Testosterone Levels ◽  
Study Population ◽  
Low Testosterone ◽  
Type 2 Diabetic ◽  
Control Study

Diabetes mellitus, an endocrine disorder, has been implicated in many including hypogonadism in men. Given the fact that diabetes mellitus is becoming a fast-growing epidemic and the morbidity associated with it is more disabling than the disease itself. This study sought to assess the prevalence of low testosterone levels and predictors in type 2 diabetes mellitus patients and non-diabetic men in a district hospital in Ghana. This hospital-based case-control study comprised 150 type 2 diabetics and 150 healthy men. A pre-structured questionnaire and patient case notes were used to document relevant demographic and clinical information. Venous blood sample of about 6 ml was taken to measure FBS, HbA1c, FSH, LH, and testosterone levels. All data were analyzed using STATA version 12 (STATA Corporation, Texas, USA). The overall hypogonadism in the study population was 48% (144/300). The prevalence of hypogonadism in type 2 diabetic subjects was almost three times more than in healthy men (70.7% vs 25.3%). The odds of having hypogonadism was lower in the men with normal weight and overweight with their underweight counterparts (AOR = 0.33, 95% CI; 0.12–0.96, p = 0.042) and (AOR = 0.29, 95% CI; 0.10–0.84, p = 0.023) respectively. Also, the odds of suffering from hypogonadism was lower in non-smokers compared with smokers (AOR: 0.16, 95% CI; 0.05–0.58, p = 0.005). Participants who were engaged in light (AOR: 0.29, 95% CI; 0.14–0.61, p = 0.001), moderate (AOR: 0.26, 95% CI; 0.13–0.54, p<0.001) and heavy (AOR: 0.25, 95% CI; 0.10–0.67, p = 0.006) leisure time activities had lower odds hypogonadal compared to those engaged in sedentary living. Type 2 diabetic men have high incidence of hypogonadism, irrespective of their baseline clinical, lifestyle or demographic characteristics. Smoking and sedentary lifestyle and BMI were associated with hypogonadism in the study population. Routine testosterone assessment and replacement therapy for high risk patients is recommended to prevent the detrimental effect of hypogonadism in diabetic men.

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