Prevention of gonadal toxicity and preservation of gonadal function and fertility in young women with systemic lupus erythematosus treated by cyclophosphamide: The PREGO-Study

2006 ◽  
Vol 5 (4) ◽  
pp. 269-272 ◽  
Author(s):  
Karin Manger ◽  
Ludwig Wildt ◽  
Joachim R. Kalden ◽  
Bernhard Manger
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Gonadal Function ◽  
Systemic Lupus ◽  
Gonadal Toxicity

Gonadal function in adolescents and young women with juvenile systemic lupus erythematosus

Lupus ◽  
2002 ◽  
Vol 11 (7) ◽  
pp. 419-425 ◽  
Author(s):  
C A A Silva ◽  
M M Leal ◽  
C Leone ◽  
V P Simone ◽  
A D Takiuti ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Gonadal Function ◽  
Systemic Lupus ◽  
Juvenile Systemic Lupus Erythematosus

Myocardial Infarction in Systemic Lupus Erythematosus – the Sex Specific Risk Profile

2020 ◽  
Vol 26 ◽  
Author(s):  
Marija Vavlukis ◽  
Daniela Pop-Gjorceva ◽  
Lidija Poposka ◽  
Emilija Sandevska ◽  
Sasko Kedev
Keyword(s):  
Myocardial Infarction ◽  
Systemic Lupus Erythematosus ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Molecular Mechanisms ◽  
Clinical Presentation ◽  
Systemic Lupus ◽  
Antiinflammatory Therapy

Background: Accelerated atherosclerosis is widely present in patients with systemic lupus erythematosus. Objective: The aim of this review is to analyze the relationship between systemic lupus erythematosus and cardiovascular diseases, with the emphasis on acute myocardial infarction. Results: Various molecular mechanisms triggered by infection/inflammation are responsible for endothelial dysfunction and development of atherosclerosis at an earlier age. Contributing factor is the cumulative effect of traditional cardiovascular risk factors interaction with disease related characteristics. Myocardial infarction rates are 2- to 10-fold higher compared to the general population. Young women have the highest relative risk, however, men carry at least 3- fold higher risk than women. Coronary involvement varies from normal coronary artery with thrombosis, coronary microartery vasculitis, coronary arteritis, and coronary atherosclerosis. Typical clinical presentation is observed in men and older women, while atypical is more frequent in young women. Treatment is guided by the underlying mechanism, engaging invasive procedures alone, or accompanied with immunosuppressive and/or antiinflammatory therapy. There are significant gender differences in pathophysiology and clinical presentation. However, they receive the same therapeutic treatments. Conclusion: Systemic lupus erythematosus is a major contributor to atherosclerotic and non-atherosclerotic mechanisms involved in the development of myocardial infarction, which should be taken into account during therapeutic treatment. Although Systemic lupus erythematosus per se is a “female” disease, males are at increased cardiovascular risk and worse outcome. Method: We conducted a literature review through PubMed and Cochrane, using key words: SLE, atherosclerosis, atherothrombosis, coronary artery disease, myocardial infarction, prognosis, sex specifics.

Do adverse pregnancy outcomes contribute to accelerated cardiovascular events seen in young women with systemic lupus erythematosus?

Lupus ◽  
2017 ◽  
Vol 26 (13) ◽  
pp. 1351-1367 ◽  
Author(s):  
M C Soh ◽  
C Nelson-Piercy ◽  
M Westgren ◽  
L McCowan ◽  
D Pasupathy
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Cardiovascular Disease ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Pregnancy Outcomes ◽  
Cardiovascular Events ◽  
Adverse Pregnancy Outcomes ◽  
Systemic Lupus ◽  
Adverse Pregnancy

Cardiovascular events (CVEs) are prevalent in patients with systemic lupus erythematosus (SLE), and it is the young women who are disproportionately at risk. The risk factors for accelerated cardiovascular disease remain unclear, with multiple studies producing conflicting results. In this paper, we aim to address both traditional and SLE-specific risk factors postulated to drive the accelerated vascular disease in this cohort. We also discuss the more recent hypothesis that adverse pregnancy outcomes in the form of maternal–placental syndrome and resultant preterm delivery could potentially contribute to the CVEs seen in young women with SLE who have fewer traditional cardiovascular risk factors. The pathophysiology of how placental-mediated vascular insufficiency and hypoxia (with the secretion of placenta-like growth factor (PlGF) and soluble fms-tyrosine-like kinase-1 (sFlt-1), soluble endoglin (sEng) and other placental factors) work synergistically to damage the vascular endothelium is discussed. Adverse pregnancy outcomes ultimately are a small contributing factor to the complex pathophysiological process of cardiovascular disease in patients with SLE. Future collaborative studies between cardiologists, obstetricians, obstetric physicians and rheumatologists may pave the way for a better understanding of a likely multifactorial aetiological process.

scholarly journals Kikuchi-Fujimoto disease: three case reports

2010 ◽  
Vol 128 (4) ◽  
pp. 232-235 ◽  
Author(s):  
Alexandre de Andrade Sousa ◽  
João Marcos Arantes Soares ◽  
Marco Homero de Sá Santos ◽  
Marcelo Portes Rocha Martins ◽  
José Maria Porcaro Salles
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Differential Diagnosis ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Viral Infections ◽  
Case Reports ◽  
Excisional Biopsy ◽  
Review Of The Literature ◽  
Systemic Lupus ◽  
Specific Therapy

CONTEXT: Kikuchi-Fujimoto disease (KFD) manifests in most cases as unilateral cervical lymphadenomegaly, with or without accompanying fever. The disease mainly affects young women and has a self-limited course. It is more common in oriental countries, with few reports of its occurrence in Brazil. KFD should be included in the differential diagnosis of suspected cases of viral infections, tuberculosis, reactive lymphadenitis, systemic lupus erythematosus and metastatic diseases. It can be histologically confused with lymphoma. The disease is benign and self-limiting and an excisional biopsy of an affected lymph node is necessary for diagnosis. There is no specific therapy. CASE REPORTS: This study reports on three cases of non-Asian female patients with KFD who were attended at our service between 2003 and 2006. A review of the literature was carried out, with a systematic search on this topic, with the aim of informing physicians about this entity that is manifested by cervical masses and fever.

scholarly journals Cerebral Lupus and Cryptococcal Meningitis in a Pregnant Woman

2020 ◽  
Vol 11 (01) ◽  
pp. 183-186
Author(s):  
Ching Soong Khoo ◽  
Marsilla Mariaty Marzukie ◽  
Soo Shu Yap ◽  
Wan Nur Nafisah Wan Yahya ◽  
Hui Jan Tan
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Pregnant Woman ◽  
Pregnant Women ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Cryptococcal Meningitis ◽  
Neuropsychiatric Lupus ◽  
Systemic Lupus ◽  
Multisystem Disorder ◽  
Hematological Manifestations

AbstractSystemic lupus erythematosus (SLE) is a chronic autoimmune and multisystem disorder, which frequently affects young women. During pregnancy, SLE flares could occur up to 65%, with renal and hematological manifestations being the most common. However, reports on neuropsychiatric lupus in pregnant women are scarce. We herein report a 26-year-old lupus pregnant woman, who had cerebral lupus with concurrent cryptococcal meningitis. This case highlights the complexity in diagnosing and managing our patient to achieve the best outcome for both the mother and infant.

High-density lipoproteins are abnormal in young women with uncomplicated systemic lupus erythematosus

Lupus ◽  
2008 ◽  
Vol 17 (11) ◽  
pp. 981-987 ◽  
Author(s):  
JG Juárez-Rojas ◽  
AX Medina-Urrutia ◽  
R Posadas-Sánchez ◽  
E Jorge-Galarza ◽  
E Mendoza-Pérez ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Young Women ◽  
Lupus Erythematosus ◽  
High Density ◽  
High Density Lipoproteins ◽  
Systemic Lupus

scholarly journals AB0338 PREGNANCY OUTCOMES IN ADOLESCENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1194.1-1194
Author(s):  
P. Alba ◽  
Y. Tissera ◽  
N. Cucchiaro ◽  
V. Savio ◽  
R. Serrano Morales ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Adolescent Pregnancy ◽  
Pregnancy Outcome ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Pregnancy Outcomes ◽  
Fetal Outcome ◽  
Maternal Outcomes ◽  
Systemic Lupus ◽  
Fetal Outcomes

Background:Systemic lupus erythematosus (SLE) is a autoimmune disease that affects adolescents and young women of childbearing age. In spite of the improvement in fetal and maternal SLE pregnancy outcome in the last decades, they have increased risk of adverse outcomes including disease flare, abortions, preeclampsia (PE) and premature birth (PB). However, pregnancy outcomes among adolescents with SLE have not been well explored.Objectives:To evaluate maternal and fetal outcomes in pregnant adolescents with SLE.Methods:We retrospectively studied all pregnant SLE adolescent patients, who attended to 3 Maternity Hospitals in Argentina in the last 5 years. Demographic, clinical, and laboratory data were collected. The presence of Antiphospholipid Syndrome (APS) and the Antiphospholipid antibodies (AA), and maternal and fetal outcome were evaluated. Adolescent pregnancy was defined it is happened between 10 and 19 years old. Lupus activity was evaluated by SELENA SLEDAI at the conception and each trimester of pregnancy and puerperium.Results:32 pregnancies in 21 patients were included. Mean age was 18 years old, 66% was mestizo ethnicity and mean disease duration of 2 years. Renal involvement was found in 19, Mucocutaneous in 21, and hematological in 14 patients. 4 patients had positive Anti-SSA/Ro antibodies, 1 Anti-SSB/La, 2 Lupus anticoagulant, 6 Ig G ACL, 3 Ig M ACL, and 8 patients fulfilled APS criteria. Activity disease was 0 SELENA SLEDAI in 1 ° trimester, 4 in 2°,3° trimester and puerperium. Maternal and fetal outcomes are shown in Table 1. Cesarean section was performed in 58%(n=18) of the patients, 6 had abortions and 1 fetal death.Table 1.Maternal outcomesDisease Flares13(41%) 7 renal (PE)/Hellp6 (19%)Gestational Diabetes1 (3%)Maternal outcomesSpontaneous Membrane Rupture1 (3%)Mortality0Fetal outcomeLive birth24 (75%)Gestational age (weeks)32 (32-38)Weight (grs)2805 (2100-3340)IUGR5 (16%)PB8 (25%)Conclusion:Maternal and fetal complications were high in adolescent pregnancy with SLE, including disease activity, PE and PB. A tight control of patients should be performed before and after conception. These patients should be managed by a multidisciplinary team, thus allowing an improvement of maternal and fetal prognosis.References:[1]Ling N, Lawson E, von Scheven E. Adverse Pregnancy outcome in adolescents and young women with systemic lupus erythematosus: a national estimate. Pediatric Rheumatology 2018, 16:26.[2]FraserA, Brockert J, Ward R: Association of young maternal age with adverse reproductive outcomes. N Engl J Med 1995, 223:1113-1117. 26.Disclosure of Interests:None declared

scholarly journals Two Cases of Catastrophic AAA Rupture in Young Women with Systemic Lupus Erythematosus

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
David Noorvash ◽  
Kevin King ◽  
Meera Gebrael
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Emergency Department ◽  
Abdominal Aortic Aneurysm ◽  
Young Women ◽  
Lupus Erythematosus ◽  
Relevant Literature ◽  
Ruptured Abdominal Aortic Aneurysm ◽  
Past Medical History ◽  
Systemic Lupus ◽  
Abdominal Aortic

We present two cases of young women with a past medical history significant for systemic lupus erythematosus (SLE), who presented to the Emergency Department with a ruptured abdominal aortic aneurysm (AAA). These cases are of particular interest because the patients did not fit the typical demographic for patients who present with a ruptured AAA. Based on these cases and a review of the relevant literature, ED providers should maintain a higher index of suspicion for AAA rupture in patients with autoimmune diseases, especially SLE.

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