scholarly journals The role of matrix metalloproteinases in aging: Tissue remodeling and beyond

2017 ◽  
Vol 1864 (11) ◽  
pp. 2015-2025 ◽  
Author(s):  
Sandra Freitas-Rodríguez ◽  
Alicia R. Folgueras ◽  
Carlos López-Otín
Keyword(s):  
Matrix Metalloproteinases ◽  
Tissue Remodeling

Ovarian tissue remodeling: role of matrix metalloproteinases and their inhibitors

2002 ◽  
Vol 191 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Michael F. Smith ◽  
William A. Ricke ◽  
Leanne J. Bakke ◽  
Mark P.D. Dow ◽  
George W. Smith
Keyword(s):  
Matrix Metalloproteinases ◽  
Ovarian Tissue ◽  
Tissue Remodeling

scholarly journals A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage Biology

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Brandon J. Rose ◽  
David L. Kooyman
Keyword(s):  
Rheumatoid Arthritis ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Matrix Metalloproteinases ◽  
Embryonic Development ◽  
Tissue Remodeling ◽  
Matrix Metalloproteases ◽  
Extracellular Matrix Molecules ◽  
Cartilage Biology

Matrix metalloproteinases are a class of enzymes involved in the degradation of extracellular matrix molecules. While these molecules are exceptionally effective mediators of physiological tissue remodeling, as occurs in wound healing and during embryonic development, pathological upregulation has been implicated in many disease processes. As effectors and indicators of pathological states, matrix metalloproteinases are excellent candidates in the diagnosis and assessment of these diseases. The purpose of this review is to discuss matrix metalloproteinases as they pertain to cartilage health, both under physiological circumstances and in the instances of osteoarthritis and rheumatoid arthritis, and to discuss their utility as biomarkers in instances of the latter.

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