Enhanced lipid utilization is coupled to the sickness responses triggered by lipopolysaccharide

2021 ◽  
Vol 558 ◽  
pp. 44-50
Author(s):  
Byong Seo Park ◽  
Ye Jin Kim ◽  
Da Yeon Jeong ◽  
Yang Tae Kim ◽  
Jae Kwang Kim ◽  
...  
Keyword(s):  
Lipid Utilization

DDT Movement from Adipocyte to Muscle Cell during Lipid Utilization

Nature ◽  
1971 ◽  
Vol 229 (5279) ◽  
pp. 63-65 ◽  
Author(s):  
G. M. FINDLAY ◽  
A. S. W. DEFREITAS
Keyword(s):  
Muscle Cell ◽  
Lipid Utilization

scholarly journals Lipin1 Regulation by Estrogen in Uterus and Liver: Implications for Diabetes and Fertility

Endocrinology ◽  
2007 ◽  
Vol 148 (8) ◽  
pp. 3685-3693 ◽  
Author(s):  
P. Mangala Gowri ◽  
Surojeet Sengupta ◽  
Suzanne Bertera ◽  
Benita S. Katzenellenbogen
Keyword(s):  
Metabolic Regulation ◽  
Energy Use ◽  
Nod Mice ◽  
Blood Levels ◽  
Estrogen Regulation ◽  
Nonobese Diabetic ◽  
Lipid Utilization ◽  
Phosphatidic Acid Phosphatase ◽  
Target Organs ◽  
Estrogen Administration

Estrogens are essential for fertility and also have important effects on regulation of adiposity and the euglycemic state. We report here that lipin1, a candidate gene for lipodystrophy and obesity that is a phosphatidic acid phosphatase critical in regulation of cellular levels of diacylglycerol and triacylglycerol and a key regulator of lipid utilization, is rapidly and robustly down-regulated in the uterus by estradiol via the estrogen receptor. Lipin1 is expressed predominantly in the uterine luminal and glandular epithelium, and during the estrous cycle, lipin1 is lowest when blood levels of estrogen are highest. Lipin1 is expressed throughout all cells in the liver of ovariectomized female mice, and a sustained down-regulation is observed at the mRNA, protein and immunohistochemical levels after estrogen administration. Because the coupling of proper energy use and availability is central to reproduction, we also investigated expression of lipin1 in the uterus and liver of several mouse models of diabetes. Nonobese diabetic (NOD) mice, which have high blood levels of estrogen and impaired fertility, were severely deficient in lipin1 in the uterus and liver, which, interestingly, could be restored by insulin treatment. By contrast, nonobese diabetic/severe combined immunodeficient (NOD-SCID) mice, which do not develop diabetes, showed normal levels of lipin1. Our findings of lipin1 regulation by estrogen in two key target organs suggest a new role for this lipid-regulating phosphatase not only in central metabolic regulation but also in uterine function and reproductive biology. Estrogen regulation of lipin1 may provide a mechanistic link between estrogens, lipid metabolism, and lipid signaling.

Lipids and Lipid Utilization in Swine

2012 ◽  
pp. 59-79 ◽  
Author(s):  
Xi Lin ◽  
Mike Azain ◽  
Jack Odle
Keyword(s):  
Lipid Utilization

scholarly journals Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese

2019 ◽  
Vol 105 (3) ◽  
pp. 660-676 ◽  
Author(s):  
Robert M Edinburgh ◽  
Helen E Bradley ◽  
Nurul-Fadhilah Abdullah ◽  
Scott L Robinson ◽  
Oliver J Chrzanowski-Smith ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Exercise Training ◽  
Whole Body ◽  
Moderate Intensity ◽  
Type I ◽  
Training Study ◽  
Exercise Timing ◽  
Lipid Utilization ◽  
Acute Study ◽  
Intramuscular Lipid

Abstract Context Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness. Objective To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization and postprandial glucose metabolism. Design (1) Acute, randomized, crossover design (Acute Study); (2) 6-week, randomized, controlled design (Training Study). Setting General community. Participants Men with overweight/obesity (mean ± standard deviation, body mass index: 30.2 ± 3.5 kg⋅m-2 for Acute Study, 30.9 ± 4.5 kg⋅m-2 for Training Study). Interventions Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion. Results Acute Study—exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: –3.44 ± 2.63% versus 1.44 ± 4.18% area lipid staining, P < 0.01) and type II fibers (–1.89 ± 2.48% versus 1.83 ± 1.92% area lipid staining, P < 0.05). Training Study—postprandial glycemia was not differentially affected by 6 weeks of exercise training performed before versus after carbohydrate intake (P > 0.05). However, postprandial insulinemia was reduced with exercise training performed before but not after carbohydrate ingestion (P = 0.03). This resulted in increased oral glucose insulin sensitivity (25 ± 38 vs –21 ± 32 mL⋅min-1⋅m-2; P = 0.01), associated with increased lipid utilization during exercise (r = 0.50, P = 0.02). Regular exercise before nutrient provision also augmented remodeling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (P < 0.05). Conclusions Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (ie, in the fasted state) may exert beneficial effects on lipid utilization and reduce postprandial insulinemia.

Effect of high-altitude acclimation on NEFA turnover and lipid utilization during exercise in rats

1999 ◽  
Vol 277 (6) ◽  
pp. E1095-E1102 ◽  
Author(s):  
Grant B. McClelland ◽  
Peter W. Hochachka ◽  
Jean-Michel Weber
Keyword(s):  
Fatty Acid ◽  
High Altitude ◽  
Total Lipid ◽  
Nonesterified Fatty Acid ◽  
Flux Rate ◽  
Plasma Nefa ◽  
Lipid Utilization ◽  
Fuel Selection ◽  
Relative Exercise Intensity ◽  
The Relationship

Relative exercise intensity (or %maximum O2 consumption,V˙o 2 max) controls fuel selection at sea level (SL) and after high-altitude acclimation (HA) in rats. In this context we used indirect calorimetry, [1-14C]palmitate infusions, and muscle triacylglycerol (TAG) measurements to determine 1) total lipid oxidation, 2) the relationship between circulatory nonesterified fatty acid (NEFA) flux and concentration, and 3) muscle TAG depletion after exercise in HA-acclimated rats. Aerobic capacity is decreased in trained rats after 10 wk of acclimation. Both SL and HA showed the same relative use of lipids at 60% [62 ± 5% (HA) and 61 ± 3% (SL) of O2 consumption (V˙o 2)] and 80% [46 ± 6% (HA) and 47 ± 5% (SL) ofV˙o 2] of their respective V˙o 2 max. At 60% V˙o 2 max, plasma [NEFA] were higher in HA, but rate of appearance was essentially the same in both groups (at 30 min, 38 ± 9 vs. 49 ± 6 μmol ⋅ kg−1 ⋅ min−1in HA and SL, respectively). At this intensity SL showed no significant decrease in muscle TAG, but in HA it decreased by 64% in soleus and by 90% in red gastrocnemius. We conclude that 1) the relative contributions of total lipid are the same in SL and HA, contrary to differences in [NEFA], because the relationship between flux rate and [NEFA] is modified after acclimation, and 2) muscle TAG may play a more important role at HA.

Estrogen replacement stimulates fatty acid oxidation and impairs post-ischemic recovery of hearts from ovariectomized female rats

2002 ◽  
Vol 80 (10) ◽  
pp. 1001-1007 ◽  
Author(s):  
Mark Grist ◽  
Richard B Wambolt ◽  
Gregory P Bondy ◽  
Dean R English ◽  
Michael F Allard
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Oxidation ◽  
Corn Oil ◽  
Heart Function ◽  
Ischemia Reperfusion ◽  
Female Rats ◽  
Acid Oxidation ◽  
Estrogen Replacement ◽  
Lipid Utilization ◽  
Intact Rats

Women less than 50 years of age, the majority of whom are likely premenopausal and exposed to estrogen, are at greater risk of a poor short-term recovery after myocardial ischemia than men and older women. Since estrogen enhances non-cardiac lipid utilization and increased lipid utilization is associated with poor post-ischemic heart function, we determined the effect of estrogen replacement on post-ischemic myocardial function and fatty acid oxidation. Female Sprague–Dawley rats, either intact (n = 15) or ovariectomized and treated with 17β-estradiol (0.1 mg·kg–1·day–1, s.c., n = 14) or corn oil vehicle (n = 16) for 5 weeks, were compared. Function and fatty acid oxidation of isolated working hearts perfused with 1.2 mM [9,10-3H]palmitate, 5.5 mM glucose, 0.5 mM lactate, and 100 mU/L insulin were measured before and after global no-flow ischemia. Only 36% of hearts from estrogen-treated rats recovered after ischemia compared with 56% from vehicle-treated rats (p > 0.05, not significant), while 93% of hearts from intact rats recovered (p < 0.05). Relative to pre-ischemic values, post-ischemic function of estrogen-treated hearts (26.3 ± 10.1%) was significantly lower than vehicle-treated hearts (53.4 ± 11.8%, p < 0.05) and hearts from intact rats (81.9 ± 7.0%, p < 0.05). Following ischemia, fatty acid oxidation was greater in estrogen-treated hearts than in the other groups. Thus, estrogen replacement stimulates fatty acid oxidation and impairs post-ischemic recovery of isolated working hearts from ovariectomized female rats.Key words: fatty acid oxidation, estrogen, ischemia, reperfusion.

Cardiac carbohydrate and lipid utilization during late pregnancy

1993 ◽  
Vol 21 (3) ◽  
pp. 312S-312S ◽  
Author(s):  
MARY C. SUGDEN ◽  
MARK J. HOLNESS
Keyword(s):  
Late Pregnancy ◽  
Lipid Utilization
Sign in / Sign up

Export Citation Format

Share Document