ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy

2013 ◽  
Vol 45 (5) ◽  
pp. 932-943 ◽  
Author(s):  
Kehong Chen ◽  
Jianguo Zhang ◽  
Weiwei Zhang ◽  
Jinhua Zhang ◽  
Jurong Yang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation

scholarly journals Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

2015 ◽  
Vol 87 (1) ◽  
pp. 74-84 ◽  
Author(s):  
Khurrum Shahzad ◽  
Fabian Bock ◽  
Wei Dong ◽  
Hongjie Wang ◽  
Stefan Kopf ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation

scholarly journals DsbA-L Ameliorates Renal Injury Through the AMPK/NLRP3 Inflammasome Signaling Pathway in Diabetic Nephropathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Ming Yang ◽  
Shilu Luo ◽  
Na Jiang ◽  
Xi Wang ◽  
Yachun Han ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nlrp3 Inflammasome ◽  
Protective Role ◽  
Tubular Damage ◽  
Inflammasome Activation ◽  
Compound C ◽  
Nlrp3 Inflammasome Activation ◽  
Amp Activated Protein Kinase ◽  
Relationship Of ◽  
The Relationship

NLRP3-mediated inflammation is closely related to the pathological progression of diabetic nephropathy (DN). DsbA-L, an antioxidant enzyme, plays a protective role in a variety of diseases by inhibiting ER stress and regulating metabolism. However, the relationship of DsbA-L with inflammation, especially the NLRP3 inflammasome, has not been examined. In this study, we note that activation of the NLRP3 inflammasome and exacerbated fibrosis were observed in the kidneys of diabetic DsbA-L-knockout mice and were accompanied by decreased phosphorylation of AMP-activated protein kinase (AMPK). Moreover, correlation analysis shows that the phosphorylation of AMPK was negatively correlated with NLRP3 expression and tubular damage. In addition, the decreased AMPK phosphorylation and NLRP3 activation induced by high glucose (HG) in HK-2 cells could be alleviated by the overexpression of DsbA-L. Interestingly, the protective effect of DsbA-L was eliminated after treatment with compound C, a well-known AMPK inhibitor. Our findings suggest that DsbA-L inhibits NLRP3 inflammasome activation by promoting the phosphorylation of AMPK.

Targeting the NLRP3 Inflammasome in Diabetic Nephropathy

2021 ◽  
Vol 28 ◽  
Author(s):  
Ming Yang ◽  
Xi Wang ◽  
Yachun Han ◽  
Chenrui Li ◽  
Ling Wei ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Inflammatory Response ◽  
Nlrp3 Inflammasome ◽  
End Stage Renal Disease ◽  
Pathological Process ◽  
Inflammasome Activation ◽  
Nlrp3 Inflammasome Activation ◽  
Stage Renal Disease ◽  
End Stage ◽  
The Relationship

: Diabetic nephropathy (DN) is one of the most common complications of diabetes and the main cause of end-stage renal disease (ESRD). The inflammatory response plays a key role in the pathological process of DN. As the most deeply studied inflammasome, NLRP3 should not be overlooked in DN. Its abnormal activation accelerates DN progression. In this review, we summarize our understanding of the structural composition and activation factors of the NLRP3 inflammasome. Moreover, the relationship between NLRP3 inflammasome activation, and the potential of the NLRP3 inflammasome as a therapeutic target for DN will also be discussed.

scholarly journals Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation

2017 ◽  
Vol 8 (7) ◽  
pp. e2937-e2937 ◽  
Author(s):  
Shaofei Wang ◽  
Yubin Li ◽  
Jiajun Fan ◽  
Xuyao Zhang ◽  
Jingyun Luan ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nlrp3 Inflammasome ◽  
Renal Injury ◽  
Inflammasome Activation ◽  
Interleukin 22 ◽  
Nlrp3 Inflammasome Activation

scholarly journals Optineurin inhibits NLRP3 inflammasome activation by enhancing mitophagy of renal tubular cells in diabetic nephropathy

2018 ◽  
Vol 33 (3) ◽  
pp. 4571-4585 ◽  
Author(s):  
Kehong Chen ◽  
Lei Feng ◽  
Wei Hu ◽  
Jia Chen ◽  
Xiaoyue Wang ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Nlrp3 Inflammasome Activation ◽  
Renal Tubular
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