:
Vulnerability of the brain milieu to even the subtle changes in its normal physiology is guarded by a highly efficient blood
brain barrier. A number of factors i.e. molecular weight of the drug, its route of administration, lipophilic character etc. play a significant
role in its sojourn through the blood brain barrier (BBB) and limit the movement of drug into brain tissue through BBB. To overcome
these problems, alternative routes of drug administration have been explored to target the drugs to brain tissue. Nasal route has been
widely reported for the administration of drugs for treatment of Alzheimer. In this innovative approach, the challenge of BBB is bypassed. Through this route, both the larger as well as polar molecules can be made to reach the brain tissues. Generally, these systems
are either pH dependent or temperature dependent.
Results:
The present review highlights the anatomy of nose, mechanisms of drug delivery from nose to brain, critical factors in the
formulation of nasal drug delivery system, nasal formulations of various drugs that have been tried for their nasal delivery for treatment
of Alzheimer.
Conclusion:
It also dives deep to understand the factors that contribute to the success of such formulations to carve out a direction for
this niche area to be explored further.
Protein Kinase A Distribution Differentiates Human Glioblastoma from Brain Tissue
