Multicomponent reaction for the synthesis of new 1,3,4-thiadiazole-thiazolidine-4-one molecular hybrids as promising antidiabetic agents through α-glucosidase and α-amylase inhibition

2021 ◽  
pp. 105210
Author(s):  
Lalitha Gummidi ◽  
Nagaraju Kerru ◽  
Oluwakemi Ebenezer ◽  
Paul Awolade ◽  
Olakunle Sanni ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Antidiabetic Agents ◽  
Molecular Hybrids

Molecular insights on the dynamic stability of peptide nucleic acid functionalized carbon and boron nitride nanotubes

2021 ◽  
Vol 23 (1) ◽  
pp. 219-228
Author(s):  
Nabanita Saikia ◽  
Mohamed Taha ◽  
Ravindra Pandey
Keyword(s):  
Nucleic Acid ◽  
Boron Nitride ◽  
Nucleic Acids ◽  
Dynamic Stability ◽  
Peptide Nucleic Acid ◽  
Rational Design ◽  
Peptide Nucleic Acids ◽  
Boron Nitride Nanotubes ◽  
Molecular Hybrids ◽  
Single Wall Nanotubes

The rational design of self-assembled nanobio-molecular hybrids of peptide nucleic acids with single-wall nanotubes rely on understanding how biomolecules recognize and mediate intermolecular interactions with the nanomaterial's surface.

The Safety of Linagliptin vs. Other Antidiabetic Agents with Regard to the Risk of Heart Failure Hospitalization in Routine Care in the U.S.

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2364-PUB
Author(s):  
ELISABETTA PATORNO ◽  
MUFADDAL MAHESRI ◽  
CHANDRASEKAR GOPALAKRISHNAN ◽  
KIMBERLY BRODOVICZ ◽  
ANDREA MEYERS ◽  
...  
Keyword(s):  
Heart Failure ◽  
Routine Care ◽  
Heart Failure Hospitalization ◽  
Antidiabetic Agents ◽  
The U.S

scholarly journals Electrochemical multicomponent synthesis of 4-selanylpyrazoles under catalyst- and chemical-oxidant-free conditions

2021 ◽  
Author(s):  
Yan Wu ◽  
Jin-Yang Chen ◽  
Jing Ning ◽  
Xue Jiang ◽  
Jie Deng ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Raw Materials ◽  
Multicomponent Synthesis ◽  
Mild Conditions ◽  
Simple Protocol ◽  
High Yields

An electrochemical multicomponent reaction was established under catalyst-, chemical-oxidant-free and mild conditions, which provides an eco-friendly and simple protocol for constructing 4-selanylpyrazoles from easily available raw materials with high yields.

ChemInform Abstract: Multicomponent Reaction for Synthesis of 2-(Indol-3-yl)pyridine Derivatives under Microwave Irradiation.

ChemInform ◽  
2012 ◽  
Vol 43 (18) ◽  
pp. no-no
Author(s):  
Li-Jun Geng ◽  
Guo-Liang Feng ◽  
Jiu-Gao Yu ◽  
Hong-Li Zhang ◽  
Yu-Mei Zhang
Keyword(s):  
Microwave Irradiation ◽  
Multicomponent Reaction ◽  
Pyridine Derivatives

Prediction of multicomponent reaction yields using machine learning

2021 ◽  
Author(s):  
Xing‐Yong Zhu ◽  
Chuan‐Kun Ran ◽  
Ming Wen ◽  
Gui‐Ling Guo ◽  
Yuan Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Multicomponent Reaction

scholarly journals Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 303
Author(s):  
András Gy. Németh ◽  
Renáta Szabó ◽  
György Orsy ◽  
István M. Mándity ◽  
György M. Keserű ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Simple Filtration

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

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