scholarly journals Cancer protective effects of plums: A systematic review

2022 ◽  
Vol 146 ◽  
pp. 112568
Author(s):  
Abdul Alim Bahrin ◽  
Said Moshawih ◽  
Jagjit Singh Dhaliwal ◽  
Mahibub Mahahamadsa Kanakal ◽  
Abdullah Khan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Protective Effects

The Associations of Plasma/Serum Carotenoids with Alzheimer’s Disease: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-12
Author(s):  
Mingyue Qu ◽  
Hanxu Shi ◽  
Kai Wang ◽  
Xinggang Wang ◽  
Nan Yu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Scoring Systems ◽  
Serum Levels ◽  
Epidemiological Studies ◽  
Pooled Analysis ◽  
Protective Effects ◽  
Mean Differences

Background: Multiple lines of evidence indicate protective effects of carotenoids in Alzheimer’s disease (AD). However, previous epidemiological studies reported inconsistent results regarding the associations between carotenoids levels and the risk of AD. Objective: Our study aims to evaluate the associations of six major members of carotenoids with the occurrence of AD by conducting a systematic review and meta-analysis. Methods: Following PRISMA guidelines, a comprehensive literature search of PubMed, Web of Science, Ebsco, and PsycINFO databases was conducted, and the quality of each included studies was evaluated by a validated scoring systems. Standardized mean differences (SMD) with 95%confidence intervals (CI) were determined by using a random effects model. Heterogeneity was evaluated by I2 statistics. Publication bias was detected using funnel plots and Egger’s test. Results: Sixteen studies, with 10,633 participants were included. Pooled analysis showed significantly lower plasma/serum levels of lutein (SMD = –0.86, 95%CI: –1.67 to –0.05, p = 0.04) and zeaxanthin (SMD = –0.59; 95%CI: –1.12 to –0.06, p = 0.03) in patients with AD versus cognitively intact controls, while α-carotene (SMD = 0.21, 95%CI: –0.68 to 0.26, p = 0.39), β-carotene (SMD = 0.04, 95%CI: –0.57 to 0.65, p = 0.9), lycopene (SMD = –0.12, 95%CI: –0.96 to 0.72, p = 0.78), and β-cryptoxanthin (SMD = –0.09, 95%CI: –0.83 to 0.65, p = 0.81) did not achieve significant differences. Conclusion: Of six major members of carotenoids, only lutein and zeaxanthin concentrations in plasma/serum were inversely related to the risk of AD. More high-quality longitudinal studies are needed to verify these findings.

The protective effects of nausea and vomiting of pregnancy against adverse fetal outcome—A systematic review

2014 ◽  
Vol 47 ◽  
pp. 77-80 ◽  
Author(s):  
Gideon Koren ◽  
Svetlana Madjunkova ◽  
Caroline Maltepe
Keyword(s):  
Systematic Review ◽  
Fetal Outcome ◽  
Nausea And Vomiting ◽  
Protective Effects ◽  
Adverse Fetal Outcome

scholarly journals Reno-protective effects of renin–angiotensin system blockade in type 2 diabetic patients: a systematic review and network meta-analysis

Diabetologia ◽  
2011 ◽  
Vol 55 (3) ◽  
pp. 566-578 ◽  
Author(s):  
P. Vejakama ◽  
A. Thakkinstian ◽  
D. Lertrattananon ◽  
A. Ingsathit ◽  
C. Ngarmukos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Renin Angiotensin System ◽  
Diabetic Patients ◽  
Protective Effects ◽  
Type 2 Diabetic Patients ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Type 2 Diabetic

scholarly journals Leishmanicidal effects of resveratrol and its derivatives: a systematic review and meta-Analysis

2020 ◽  
Author(s):  
Nasrin Amiri Dashatan ◽  
Marzieh Ashrafmansouri ◽  
Mehdi Koushki ◽  
Nayebali Ahmadi
Keyword(s):  
Systematic Review ◽  
Publication Bias ◽  
Data Extraction ◽  
Meta Analysis ◽  
Sensitivity Analyses ◽  
Protective Effects ◽  
Random Effects Models ◽  
Important Health ◽  
Mean Differences ◽  
Meta Analyses

Abstract Background Leishmaniasis is one of the most important health problems worldwide. The evidence has suggested that resveratrol and its derivatives have anti-leishmanial effects; however, the results are inconsistent and inconclusive. The aim of this study was to assess the effect of resveratrol and its derivatives on the Leishmania viability through a systematic review and meta-analysis of available relevant studies. Methods The electronic databases PubMed, ScienceDirect, Embase, Web of Science and Scopus were queried between October 2000 and April 2020 using a comprehensive search strategy. The eligible articles selected and data extraction conducted by two reviewers. Mean differences of IC50 (concentration leading to reduction of 50% of Leishmania) for each outcome was calculated using random-effects models. Sensitivity analyses and prespecified subgroup were conducted to evaluate potential heterogeneity and the stability of the pooled results. Publication bias was evaluated using the Egger’s and Begg’s tests. We also followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for this review. Results Ten studies were included in the meta-analysis. We observed that RSV and its derivatives had significant reducing effects on Leishmania viability in promastigote [24.02 µg/ml; (95% CI 17.1, 30.8); P < 0.05; I2 = 99.8%; P heterogeneity = 0.00] and amastigote [18.3 µg/ml; (95% CI 13.5, 23.2); P < 0.05; I2 = 99.6%; P heterogeneity = 0.00] stages of Leishmania. A significant publication bias was observed in the meta-analysis. Sensitivity analyses showed a similar effect size while reducing the heterogeneity. Subgroup analysis indicated that the pooled effects of leishmanicidal of resveratrol and its derivatives were affected by type of stilbenes and Leishmania species. Conclusions Our findings clearly suggest that the strategies for the treatment of leishmaniasis should be focused on natural products such as RSV and its derivatives. Further study is needed to identify the mechanisms mediating this protective effects of RSV and its derivatives in leishmaniasis.

scholarly journals Effect of anticoagulants and antiplatelet agents on the efficacy of intravesical BCG treatment of bladder cancer: A systematic review

2013 ◽  
Vol 7 (11-12) ◽  
pp. 740 ◽  
Author(s):  
Nader Fahmy ◽  
Alejandro Lazo-Langner ◽  
Alla E. Iansavichene ◽  
Stephen E. Pautler
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Bladder Tumour ◽  
Antiplatelet Agents ◽  
Protective Role ◽  
Protective Effects ◽  
Increased Risk ◽  
Intravesical Bcg ◽  
The Impact ◽  
Group 1

We performed a systematic review of publications describing a correlation between oral anticoagulant medications and intravesical BCG outcome. We collected information on the impact of such medications on tumour recurrence and progression and we excluded papers not reporting outcome correlations. Patients were divided into group 1 and 2 based on whether they were taking or not taking any anticoagulant medications. A total of 7 manuscripts published between 1990 and 2009 were included in this study. Data heterogeneity precluded meta-analysis. In studies combining all anticoagulant medications, 3 out of 5 (60%) publications did not identify any difference in outcome, while 2 (40%) documented significantly more recurrences in group 1 patients. In studies performing multivariate analysis and only examining the intake of 1 medication, warfarin alone seemed to be associated with increased risk of bladder tumour recurrences and progression following intravesical BCG treatment, while ASA alone seemed to be associated with more protective effects. There is no strong evidence to support the allegations of a protective role of ASA and a deleterious role for warfarin. Further, well-designed experimental and clinical studies are needed to clarify the mechanism of action of intravesical BCG along with possible drug interactions. 

Additively protective effects of vitamin D and calcium against colorectal adenoma incidence, malignant transformation and progression: A systematic review and meta-analysis

2020 ◽  
Vol 39 (8) ◽  
pp. 2525-2538 ◽  
Author(s):  
Dongdong Huang ◽  
Siqin Lei ◽  
Yihua Wu ◽  
Menghan Weng ◽  
Yuwei Zhou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
Malignant Transformation ◽  
Colorectal Adenoma ◽  
Meta Analysis ◽  
Protective Effects

Protective effects of anti-oxidant supplementations on contrast-induced nephropathy after coronary angiography: an updated and comprehensive meta-analysis and systematic review

2016 ◽  
pp. 610-626 ◽  
Author(s):  
Sadeq Ali-Hasan-Al-Saegh ◽  
Seyed Jalil Mirhosseini ◽  
Zahra Ghodratipour ◽  
Zahra Sarafan-Chaharsoughi ◽  
Ali Mohammad Dehghan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Coronary Angiography ◽  
Meta Analysis ◽  
Protective Effects ◽  
Contrast Induced Nephropathy ◽  
Anti Oxidant

Radio-protective Effects and Mechanisms of Medicinal Plants against X-ray: A Systematic Review

2019 ◽  
Vol 25 (1) ◽  
pp. 1-11
Author(s):  
Mohamad Ali Dayani ◽  
Saeid Heidari-Soureshjani ◽  
Johannes Salcher
Keyword(s):  
Systematic Review ◽  
Medicinal Plants ◽  
Protective Effects ◽  
X Ray

scholarly journals Prescribed footwear and orthoses are not prophylactic in preventing lower extremity injuries in military tactical athletes: a systematic review with meta-analysis

2021 ◽  
pp. e001955
Author(s):  
Scott L Paradise ◽  
J R Beer ◽  
C A Cruz ◽  
K M Fechner ◽  
A J MacGregor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lower Extremity ◽  
Meta Analysis ◽  
Technical Information ◽  
Lower Extremity Injury ◽  
Overuse Injuries ◽  
Foot Orthoses ◽  
Protective Effects ◽  
Military Members ◽  
Athletic Shoes

IntroductionMilitary members are exposed to high cumulative physical loads that frequently lead to injury. Prescribed footwear and orthoses have been used to prevent injury. The purpose of this systematic review with meta-analysis was to assess if prescribed prophylactic footwear or foot orthoses reduced the risk of lower extremity injury in military tactical athletes.MethodsMEDLINE, Embase, Web of Science, Cumulative Index to Nursing and Allied Health Literature, SportDiscus, and Defense Technical Information Center databases were searched for randomised controlled trials published at any time that compared foot orthoses or prescribed footwear (to include shock-absorbing insoles and socks) with a placebo intervention or a no-treatment control. Methodological quality was assessed and the number of injuries, population at risk and duration of the study epoch were extracted and relative risk (RR) calculated. An omnibus meta-analysis was performed assessing all prescribed footwear and orthoses intervention studies, with subgroup analyses conducted on studies with similar interventions (ie, basketball athletic shoes, athletic shoes (prescribed by foot type), foot orthoses, shock-absorbing insoles, socks, tropical combat boots).ResultsOf 1673 studies identified, 22 were included. Three of eight studies that employed orthoses demonstrated significantly reduced overuse injuries compared with no-treatment controls (RR range: 0.34–0.68); one study showed neoprene insoles significantly decreased overuse injuries (RR: 0.75). There were no other significant effects in the individual studies and no protective effects observed in the omnibus meta-analysis or in the component subanalyses.ConclusionsPrescribed footwear and orthoses do not appear to have a prophylactic effect on lower quarter musculoskeletal injuries in military members and cannot be recommended at this time.

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