Joint effects of genomic markers and urinary methylation capacity associated with inorganic arsenic metabolism on the occurrence of cancers among residents in arseniasis-endemic areas: A cohort subset with average fifteen-year follow-up

Chronic arsenic (As) exposure is a critical public health issue. The As metabolism can be influenced by many factors. The objective of this study is to verify if these factors influence As metabolism in four Italian areas affected by As pollution. Descriptive analyses were conducted on 271 subjects aged 20–49 in order to assess the effect of each factor considered on As methylation. Percentages of metabolites of As in urine, primary and secondary methylation indexes were calculated as indicators for metabolic capacity. The results indicate that women have a better methylation capacity (MC) than men, and drinking As-contaminated water from public aqueducts is associated with poorer MC, especially in areas with natural As pollution. In areas with anthropogenic As pollution occupational exposure is associated with a higher MC while smoking with a poorer MC. Dietary habits and genetic characteristics are probably implicated in As metabolism. BMI, alcohol consumption and polymorphism of the AS3MT gene seem not to influence As MC. Arsenic metabolism may be affected by various factors and in order to achieve a comprehensive risk assessment of As-associated disease, it is crucial to understand how these factors contribute to differences in As metabolism.

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A pilot study: The importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome

Environmental Toxicology and Pharmacology ◽

10.1016/j.etap.2013.10.006 ◽

2013 ◽

Vol 36 (3) ◽

pp. 1266-1275 ◽

Cited By ~ 14

Author(s):

Elyssa R. Gelmann ◽

Eugen Gurzau ◽

Anca Gurzau ◽

Walter Goessler ◽

Julie Kunrath ◽

...

Keyword(s):

Individual Differences ◽

Birth Weight ◽

Pilot Study ◽

Inorganic Arsenic ◽

Arsenic Metabolism

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Relation of polymorphism of arsenic metabolism genes to arsenic methylation capacity and developmental delay in preschool children in Taiwan

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2017.02.016 ◽

2017 ◽

Vol 321 ◽

pp. 37-47 ◽

Cited By ~ 11

Author(s):

Ru-Lan Hsieh ◽

Chien-Tien Su ◽

Horng-Sheng Shiue ◽

Wei-Jen Chen ◽

Shiau-Rung Huang ◽

...

Keyword(s):

Preschool Children ◽

Developmental Delay ◽

Arsenic Metabolism ◽

Arsenic Methylation ◽

Methylation Capacity

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Unusual intramuscular locations as a first presentation of hydatid cyst disease in children: a report of two cases

BMC Pediatrics ◽

10.1186/s12887-021-02843-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Ruba A. Khasawneh ◽

Ziyad M. Mohaidat ◽

Rawand A. Khasawneh ◽

Sohaib B. Zoghoul ◽

Yousef M. Henawi

Keyword(s):

Hydatid Cyst ◽

Hydatid Disease ◽

Rectus Femoris ◽

Mri Imaging ◽

Palpable Lump ◽

First Case ◽

Endemic Areas ◽

Wbc Count ◽

The Right

Abstract Background Hydatid disease is an endemic disease in many countries of the world including the Middle East. It mainly affects the liver and lungs. Intramuscular hydatid disease is rarely reported in children. Such uncommon localization of hydatid cyst may pose difficulties in the clinical and radiological diagnosis; hence affecting patient’s management and outcome even in endemic areas. Case presentation We herein describe intramuscular hydatid cysts in 2 different children. The first case is a 5-year-old boy who presented with a painless palpable lump over the right lumbar paraspinal region. His history was remarkable for sheep contact. His laboratory results revealed a mild increase in white blood cell (WBC) count and C-reactive protein. The lesion showed typical features of a hydatid cyst on ultrasound. Further imaging including ultrasound of the abdomen and CT of the chest, abdomen, and pelvis showed infestation of the liver and lung as well. The lesions were resected surgically without complications. The patient received Albendazole preoperatively and after surgery for 3 months. No evidence of recurrence was seen during follow-up. The second case is a 6-year-old girl who presented with an incidental palpable lump in her left thigh during her hospital admission for recurrent meningitis. Ultrasound and MRI imaging were performed demonstrating a unilocular cystic lesion in the left proximal rectus femoris muscle. A provisional diagnosis of hematoma vs. myxoma was given. Biopsy was performed and yielded blood products only. The lesion was resected surgically with a postoperative diagnosis of hydatid cyst. Blood tests performed afterward showed a positive titer for Echinococcus. The patient received Albendazole for 3 months. No evidence of recurrence was seen during follow-up. Conclusions Despite its rarity; skeletal muscle hydatid cyst should always be considered in the differential diagnosis of cystic muscle lesions in children in endemic areas even if imaging studies did not show any of the typical signs. This will improve patient outcome by preventing unnecessary cystic puncture which might lead to serious complications, such as anaphylaxis and local dissemination.

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Dose–response relationship between inorganic arsenic exposure and lung cancer among arseniasis area residents with low methylation capacity: A population-based cohort study

European Journal of Cancer ◽

10.1016/s0959-8049(16)61545-9 ◽

2016 ◽

Vol 61 ◽

pp. S154

Author(s):

P.J. Liao ◽

K.H. Hsu

Keyword(s):

Lung Cancer ◽

Cohort Study ◽

Dose Response ◽

Arsenic Exposure ◽

Inorganic Arsenic ◽

Population Based ◽

Response Relationship ◽

Dose Response Relationship ◽

Methylation Capacity

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Individual Variations in Inorganic Arsenic Metabolism Associated with AS3MT Genetic Polymorphisms

International Journal of Molecular Sciences ◽

10.3390/ijms12042351 ◽

2011 ◽

Vol 12 (4) ◽

pp. 2351-2382 ◽

Cited By ~ 60

Author(s):

Tetsuro Agusa ◽

Junko Fujihara ◽

Haruo Takeshita ◽

Hisato Iwata

Keyword(s):

Genetic Polymorphisms ◽

Inorganic Arsenic ◽

Arsenic Metabolism ◽

Individual Variations

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Abstract MP86: The Joint Effect of Outdoor Recreational Activity and 25-Hydroxyvitamin D on Cardiovascular Mortality in THE NHANES III Population

Circulation ◽

10.1161/circ.127.suppl_12.amp86 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Macarius Donneyong ◽

Carlton A Hornung

Keyword(s):

Elevated Risk ◽

Physical Activities ◽

Mortality Data ◽

Nhanes Iii ◽

Additive Interaction ◽

Joint Effects ◽

The Past ◽

Increased Risk ◽

Cvd Mortality

Purpose Recreational physical activity (PA) reduces the risk of cardiovascular disease (CVD) morbidity and mortality. Outdoor-based recreational physical activities (ORA) have been reported to be associated with elevated 25(OH)D levels. We investigate the joint effects of frequent ORA and 25(OH)D levels on the risk of CVD mortality and the modifying effects of 25(OH)D. Methods Our sample consisted of 13,031 nationally representative adults (20 - 90 years old) free from CVD and cancer at baseline in the NHANES III (1988 - 1994) linked mortality dataset with follow-up mortality data through 2006. CVD mortality was based on reported deaths with corresponding ICD-10 codes for CVD as underlying cause of death. ORA was defined as self-reported participation in recreational physical activities considered to have occurred outdoors in the past month. Time to CVD mortality was estimated from multivariable adjusted Cox proportional hazards (CPH) models. A joint effects model was used in estimating multiplicative and additive interaction between ORA and 25(OH)D. Results A crude unweighted CVD mortality rate of 7.4% (964/13,031) occurred during a median follow-up of 14.33 years. Frequency of ORA <5 in the past month (HR=1.38, 95%CI:1.09 - 1.75) and 25(OH)D <30 ng/mL (HR=1.28, 95%CI:1.01 - 1.60) were associated with increased risk of CVD mortality compared to ORA ≥5 and 25(OH)D ≥30 ng/mL respectively, in a multivariable adjusted CPH model. In the joint effects model, frequency of ORA <5 and 25(OH)D <30 ng/mL (HR=1.81, 95%CI:1.05 - 3.10) and frequency of ORA <5 and 25(OH)D ≥30 ng/mL (HR=1.33, 95%CI:1.02 - 1.73) were associated with elevated risk of CVD mortality compared to the joint effects of ORA ≥5 and 25(OH)D ≥30 ng/mL. The joint effects model indicated the presence of multiplicative interaction. The synergy index, 1.52 (95%CI:0.31 - 7.41) suggested presence of additive interaction even though not statistically significant. Conclusion Lower frequency of ORA and serum 25(OH)D levels were jointly associated with elevated risk of CVD mortality. Serum 25(OH)D modified the risk of CVD mortality associated with lower frequency of outdoor-based recreational activities.

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