scholarly journals Factors Affecting Arsenic Methylation in Contaminated Italian Areas

2020 ◽  
Vol 17 (14) ◽  
pp. 5226
Author(s):  
Elisa Bustaffa ◽  
Francesca Gorini ◽  
Fabrizio Bianchi ◽  
Fabrizio Minichilli
Keyword(s):  
Dietary Habits ◽  
Public Health Issue ◽  
Contaminated Water ◽  
Metabolic Capacity ◽  
Genetic Characteristics ◽  
Arsenic Metabolism ◽  
Factors Affecting ◽  
Arsenic Methylation ◽  
Methylation Capacity ◽  
Critical Public Health

Chronic arsenic (As) exposure is a critical public health issue. The As metabolism can be influenced by many factors. The objective of this study is to verify if these factors influence As metabolism in four Italian areas affected by As pollution. Descriptive analyses were conducted on 271 subjects aged 20–49 in order to assess the effect of each factor considered on As methylation. Percentages of metabolites of As in urine, primary and secondary methylation indexes were calculated as indicators for metabolic capacity. The results indicate that women have a better methylation capacity (MC) than men, and drinking As-contaminated water from public aqueducts is associated with poorer MC, especially in areas with natural As pollution. In areas with anthropogenic As pollution occupational exposure is associated with a higher MC while smoking with a poorer MC. Dietary habits and genetic characteristics are probably implicated in As metabolism. BMI, alcohol consumption and polymorphism of the AS3MT gene seem not to influence As MC. Arsenic metabolism may be affected by various factors and in order to achieve a comprehensive risk assessment of As-associated disease, it is crucial to understand how these factors contribute to differences in As metabolism.

scholarly journals Factors affecting arsenic methylation capacity

2019 ◽  
Vol 3 ◽  
pp. 272
Author(s):  
Bustaffa E ◽  
Minichilli F ◽  
Bianchi F
Keyword(s):  
Factors Affecting ◽  
Arsenic Methylation ◽  
Methylation Capacity

scholarly journals Association between Dyslipidemia and Mercury Exposure in Adults

2021 ◽  
Vol 18 (2) ◽  
pp. 775
Author(s):  
Purum Kang ◽  
Hye Young Shin ◽  
Ka Young Kim
Keyword(s):  
Behavioral Interventions ◽  
Dietary Habits ◽  
Subjective Health ◽  
Targeted Prevention ◽  
Adult Males ◽  
Subjective Health Status ◽  
Factors Affecting ◽  
Health And Nutrition ◽  
Metal Levels ◽  
Using Data

Background—Dyslipidemia is one of the prominent risk factors for cardiovascular disease, which is the leading cause of death worldwide. Dyslipidemia has various causes, including metabolic capacity, genetic problems, physical inactivity, and dietary habits. This study aimed to determine the association between dyslipidemia and exposure to heavy metals in adults. Methods—Using data from the seventh Korean National Health and Nutrition Examination Survey (2016–2017), 5345 participants aged ≥20 years who were tested for heavy metal levels were analyzed in this study. Multiple logistic regression was conducted to assess the factors affecting the prevalence of dyslipidemia. Results—The risks of dyslipidemia among all and male participants with mercury (Hg) levels of ≥2.75 μg/L (corresponding to the Korean average level) were 1.273 and 1.699 times higher than in those with levels of <2.75 μg/L, respectively. The factors that significantly affected the dyslipidemia risk were age, household income, body mass index, and subjective health status in both males and females. Conclusions—In adult males, exposure to Hg at higher-than-average levels was positively associated with dyslipidemia. These results provide a basis for targeted prevention strategies for dyslipidemia using lifestyle guidelines for reducing Hg exposure and healthy behavioral interventions.

scholarly journals Physical and Sedentary Activities and Childhood Overweight/Obesity: A Cross-Sectional Study among First-Year Children of Primary Schools in Modena, Italy

2021 ◽  
Vol 18 (6) ◽  
pp. 3221
Author(s):  
Stefania Paduano ◽  
Antonella Greco ◽  
Lucia Borsari ◽  
Chiara Salvia ◽  
Stefano Tancredi ◽  
...  
Keyword(s):  
Digital Media ◽  
Primary Schools ◽  
Parental Education ◽  
Protective Factor ◽  
Dietary Habits ◽  
Family Characteristics ◽  
Public Health Issue ◽  
First Year ◽  
Cross Sectional ◽  
Sedentary Activities

Children obesity is a serious public health issue. This study aimed to investigate physical/sedentary activities of first-year primary schools children in Modena, and their association with overweight/obesity and dietary habits of children and family characteristics to identify the risk factors for unhealthy lifestyles. Child physical/sedentary activities were gathered through an anonymous questionnaire administered to parents, as well as family characteristics and weight/height of child and parents. Logistic regression models, eventually adjusted for parents’ sociodemographic characteristics, were used to analyze data. Questionnaires were delivered by 660 families (74.2%), of which 72 without anthropometric data were excluded. Three out of four children spent in physical activities less than 7 h/week, while 63.9% dedicated to sedentary activities two or more hours/day. From multivariate analysis, the habit significantly affecting children’s overweight/obesity was spending time on tablets/Personal Computers/mobile phones/videogames. Higher parental education level resulted in a protective factor for implementing unhealthy lifestyles in terms of time dedicated to physical/sedentary activities. Our results suggest the need of interventions to increase time for physical activity and to promote a responsible use of digital media involving the entire families to reach all parents regardless of their education and nationality with a possible relapse on other family members.

scholarly journals Biodegradation of phenolic components in wastewater by micro algae: a review

2018 ◽  
Vol 162 ◽  
pp. 05009 ◽  
Author(s):  
Muthanna Al-Dahhan ◽  
Faris Al-Ani ◽  
Afaf Al-Saned
Keyword(s):  
Growth Kinetics ◽  
Continuous Operation ◽  
Contaminated Water ◽  
Factors Affecting ◽  
Growth Requirements ◽  
Operation Modes ◽  
Phenolic Components ◽  
Algae Growth ◽  
Microalgae Growth

The biodegradation of phenolic contaminant present in wastewater by micro algae has been investigated in the current research. The study focused on algae growth requirements and factors affecting algae growth in contaminated water leading to the best treatment. Different techniques used to functionalize microalgae in the treatment such as batch and continuous operation modes have been further investigated. Mechanisms for microalgae pollutants degradation and microalgae growth kinetics were also highlighted to present the required knowledge in phenol contaminant biodegradation field by microorganisms

Polymorphisms in arsenic metabolism genes, urinary arsenic methylation profile and cancer

2009 ◽  
Vol 20 (9) ◽  
pp. 1653-1661 ◽  
Author(s):  
Chi-Jung Chung ◽  
Yu-Mei Hsueh ◽  
Chyi-Huey Bai ◽  
Yung-Kai Huang ◽  
Ya-Li Huang ◽  
...  
Keyword(s):  
Methylation Profile ◽  
Arsenic Metabolism ◽  
Arsenic Methylation ◽  
Urinary Arsenic

scholarly journals Alkoxyamines Designed as Potential Drugs against Plasmodium and Schistosoma Parasites

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3838
Author(s):  
Thibaud Reyser ◽  
Tung H. To ◽  
Chinedu Egwu ◽  
Lucie Paloque ◽  
Michel Nguyen ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Theoretical Chemistry ◽  
Public Health Issue ◽  
Drug Resistant ◽  
Structure Activity ◽  
Ic50 Values ◽  
Bond Homolysis ◽  
Tropical Areas ◽  
Critical Public Health ◽  
Nanomolar Range

Malaria and schistosomiasis are major infectious causes of morbidity and mortality in the tropical and sub-tropical areas. Due to the widespread drug resistance of the parasites, the availability of new efficient and affordable drugs for these endemic pathologies is now a critical public health issue. In this study, we report the design, the synthesis and the preliminary biological evaluation of a series of alkoxyamine derivatives as potential drugs against Plasmodium and Schistosoma parasites. The compounds (RS/SR)-2F, (RR/SS)-2F, and 8F, having IC50 values in nanomolar range against drug-resistant P. falciparum strains, but also five other alkoxyamines, inducing the death of all adult worms of S. mansoni in only 1 h, can be considered as interesting chemical starting points of the series for improvement of the activity, and further structure activity, relationship studies. Moreover, investigation of the mode of action and the rate constants kd for C-ON bond homolysis of new alkoxyamines is reported, showing a possible alkyl radical mediated biological activity. A theoretical chemistry study allowed us to design new structures of alkoxyamines in order to improve the selectivity index of these drugs.

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