Biomembrane stabilization and antiulcerogenic properties of aqueous leaf extract of Gossypium barbadense L. (Malvaceae)

Some medicinal plants have been shown to have antimalarial activity when used as combination therapy. Gossypium barbadense has been used by herbal medicine practitioners in combination with other herbs, and as a monotherapy in the treatment of malarial infection. The study was, therefore, aimed at evaluating the antimalarial effect of the aqueous leaf extract of G. barbadense using mice infected with P. berghei. The suppressive effect was evaluated by administering 25 mice divided into five groups with 250, 500, and 1,000 mg/kg of aqueous leaf extract of G. barbadense, 5 mg/kg of chloroquine, and 10 mL/kg of distilled water, respectively, starting from the day of inoculation with P. berghei for four days. The curative effect was evaluated by administering 25 mice divided into five groups as above with treatment starting 72 h post inoculation with P. berghei. The results indicate that the aqueous leaf extract of G. barbadense, when used alone as monotherapy, has a non-significant (P ≥ 0.05) but slight suppressive antimalarial activity (23%) when compared with that of chloroquine (100%). The curative model also revealed that aqueous leaf extract of G. barbadense showed no significant antimalarial activity. It can be concluded that the use of aqueous leaf extract of G. barbadense as monotherapy for malaria has no significant therapeutic effect. Therefore, it is not recommended to be used alone to manage malaria infection as practiced by some herbal medicine practitioners.

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Cytoprotective and antiadhesive effects of aqueous leaf extract from Orthosiphon aristatus against uropathogenic E. coli

Planta Medica ◽

10.1055/s-0036-1596551 ◽

2016 ◽

Vol 81 (S 01) ◽

pp. S1-S381 ◽

Cited By ~ 1

Author(s):

S Sarshar ◽

MR Asadi Karam ◽

M Habibi ◽

S Bouzari ◽

X Qin ◽

...

Keyword(s):

Leaf Extract ◽

E Coli ◽

Aqueous Leaf Extract

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Insecticidal Activities of the Leaf Extract of the Invasive Alien Plant, Chromolaena odorata (L.) (Asteraceae) Against Macrotermes species (Termites)

Nigeria Journal of Entomology ◽

10.36108/nje/9102/53.01.31 ◽

2019 ◽

Vol 35 (1) ◽

pp. 145-153

Author(s):

O. Uyi, ◽

I.G. Amolo ◽

A.D. Adetimehin

Keyword(s):

Leaf Extract ◽

Insect Pests ◽

Chromolaena Odorata ◽

Leaf Extracts ◽

Alien Plant ◽

Biological Efficacy ◽

Invasive Alien Plant ◽

Impregnation Technique ◽

Aqueous Leaf Extract ◽

Worker Caste

Several studies have demonstrated the biological efficacy of leaf, stem and root powders or extracts of Chromolaena odorata (L.) King and Robinson against insect pests but those that are focused on the biological efficacy of aqueous leaf extracts against Macrotermes species are scanty. Current management of termites with synthetic insecticides is being discouraged due to human and environmental hazards. Therefore, the insecticidal effectiveness of aqueous leaf extract C. odorata against Macrotermes species was investigated. Five concentrations (0, 2.5, 5.0, 7.5 and 10.0% (w/v)) of the aqueous extract of C. odorata plant were evaluated for repellency and toxicity on the worker caste of Macrotermes species following standard procedures. The filter paper impregnation technique was used for the bioassay. Percentage repellency was monitored for 30 minutes and mortality recorded at 12, 24 and 36 hours post exposure. The leaf extract of C. odorata significantly repelled 95% of Macrotermes species at the highest concentration of 10% (w/v) after 30 minutes post treatment exposure. Mortality of Macrotermes species was independent of treatment concentration, but dependent on duration of exposure. All treatment concentrations of aqueous leaf extract of C. odorata caused significant mortality against Macrotermes species ranging between 94% and 98% compared to the control; indicating very great potential for adoption and use in the management of Macrotermes species.

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Green Synthesis of Silver Nanoparticles by Allamanda cathartica L. Leaf Extract and Evaluation for Antimicrobial Activity

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2013.6.4.9 ◽

2013 ◽

Vol 6 (4) ◽

pp. 2260-2268

Author(s):

M. Linga Rao ◽

Bhumi G ◽

Savithramma N

Keyword(s):

Antimicrobial Activity ◽

Silver Nanoparticles ◽

Leaf Extract ◽

Fusarium Species ◽

Inhibition Zone ◽

Fungal Species ◽

Green Technology ◽

Metallic Silver ◽

Synthesis Of Nanoparticles ◽

Aqueous Leaf Extract

Silver nanoparticles (SNPs) exhibit tremendous applications in medicine as antimicrobial agent. The use of different parts of plants for the synthesis of nanoparticles is considered as a green technology as it does not involve any harmful chemicals. In the present study, we report a rapid biosynthesis of silver nanoparticles from aqueous leaf extract of medicinal plant Allamanda cathartica. The active phytochemicals present in the plant were responsible for the quick reduction of silver ion to metallic silver nanoparticles. The reduced silver nanoparticles were characterized by using UV-Vis spectrophotometry, Scanning Electron Microscope (SEM), Energy Dispersive Analysis of X-ray (EDAX) and Atomic Force Microscopy (AFM). The spherical shaped silver nanoparticles were observed and it was found to 19-40 nm range of size. These phytosynthesized SNPs were tested for their antimicrobial activity and it analyzed by measuring the inhibitory zone. A. cathartica aqueous leaf extract of SNPs showed highest toxicity to Pseudomonas followed by Klebsiella, Bacillus and E. coli and lowest toxicity towards Proteus. In fungal species, highest inhibition zone was noted against Rhizopus followed by Curvularia, Aspergillus flavus and Aspergillus niger and minimum inhibition zone was observed against Fusarium species. These results suggest a promising potential of Indian plant-based green chemistry for production of SNPs for biomedical and nanotechnology applications.

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