Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

2009 ◽  
Vol 19 (8) ◽  
pp. 2129-2132 ◽  
Author(s):  
Tsutomu Akama ◽  
Stephen J. Baker ◽  
Yong-Kang Zhang ◽  
Vincent Hernandez ◽  
Huchen Zhou ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Topical Treatment ◽  
Inflammatory Agent ◽  
Structure Activity ◽  
Anti Inflammatory

Structure–activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent

2013 ◽  
Vol 23 (6) ◽  
pp. 1680-1683 ◽  
Author(s):  
Tsutomu Akama ◽  
Charlotte Virtucio ◽  
Chen Dong ◽  
Richard Kimura ◽  
Yong-Kang Zhang ◽  
...  
Keyword(s):  
Structure Activity Relationships ◽  
Inflammatory Agent ◽  
Structure Activity ◽  
Anti Inflammatory

scholarly journals Structure-Activity Relationship Study on the Ethyl p-Methoxycinnamate as an Anti-Inflammatory Agent

2018 ◽  
Vol 18 (1) ◽  
pp. 60
Author(s):  
Ismiarni Komala ◽  
Supandi Supandi ◽  
Nurhasni Nurhasni ◽  
Ofa Suzanti Betha ◽  
Eka Putri ◽  
...  
Keyword(s):  
Active Sites ◽  
Structural Modification ◽  
Inflammatory Activity ◽  
Esterification Reaction ◽  
Inflammatory Agent ◽  
Kaempferia Galanga ◽  
Structure Activity ◽  
Anti Inflammatory

Ethyl p-methoxycinnamate (EPMC) (1) has been isolated as a major compound from the rhizome of Kaempferia galanga together with the other compound ethyl cinnamate (2). As reported in the literature, EPMC (1) exhibited a significant in vitro and in vivo anti-inflammatory activity. In this research, we investigated the anti-inflammatory activity of compounds 1 and 2 by using anti-denaturation of heat bovine serum albumin (BSA) method. In order to analyze active sites that are responsible for the anti-inflammatory activity, therefore, it is necessary to conduct structural modification of EPMC (1). The structural modification was performed through re-esterification reaction by using conventional and assistance of the unmodified microwave oven. Evaluation of the results of the bioassay indicated that the ester and methoxy functional groups of EPMC (1) play an important role for the anti-inflammatory activity.

Multifunctional chitosan-coated poly(lactic-co-glycolic acid) nanoparticles for spatiotemporally controlled codelivery of ceramide and C-phycocyanin to treat atopic dermatitis

2019 ◽  
Vol 34 (2) ◽  
pp. 163-177 ◽  
Author(s):  
Seul Ki Min ◽  
Hoo Cheol Lee ◽  
Hyeongi Song ◽  
Hwa Sung Shin
Keyword(s):  
Atopic Dermatitis ◽  
Stratum Corneum ◽  
Messenger Rna ◽  
Glycolic Acid ◽  
High Efficiency ◽  
Chitosan Nanoparticles ◽  
Skin Barrier ◽  
Inflammatory Agent ◽  
Anti Inflammatory

Atopic dermatitis is an inflammatory disease associated with defective skin barrier. The co-administration of a lipid-enhancing skin barrier composed of ceramide with an anti-inflammatory agent is required to effectively treat atopic dermatitis. As atopic dermatitis treatment is affected by the dosage and frequency of medication, the development of nanoparticles that have long-term efficacy with a single dose would be advantageous. In this study, skin-sensitive chitosan nanoparticles codelivering ceramide and C-phycocyanin were developed to provide anti-inflammatory effects with no cytotoxicity, and their effect on stratum corneum formation in a rat atopic dermatitis model was examined. Analysis of the messenger RNA expression of keratinization factors demonstrated that the stratum corneum–formation effect of poly(lactic-co-glycolic acid) nanoparticles containing ceramide was similar to or higher than that of ceramide alone. Compared to the nanoparticles without C-phycocyanin, nanoparticles coated with C-phycocyanin and chitosan attenuated histamine release. In addition, despite frequent washing, the nanoparticles were well fixed to the epidermis after their administration. The results suggest that a single treatment with the combination of lipid therapy/anti-inflammatory nanoparticles is a convenient and high-efficiency means to increase stratum corneum formation in atopic dermatitis patients.

Helenalin: An Anti-Inflammatory and Anti-Neoplastic Agent: A Review

2020 ◽  
Vol 16 (8) ◽  
pp. 1134-1146
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve ◽  
Uttam S. Baghel
Keyword(s):  
Rheumatoid Arthritis ◽  
Adverse Effects ◽  
Chronic Conditions ◽  
Review Article ◽  
Google Scholar ◽  
Medical Community ◽  
Inflammatory Agent ◽  
Skin Cancers ◽  
Medicinal Properties ◽  
Anti Inflammatory

Objective: Helenalin is a natural anti-inflammatory agent that is proving its efficacy to treat various medical conditions. Though many plants are proving their effectiveness but their mechanisms are still not well understood. The objective of the review is to summarize various mechanisms of helenalin to treat inflammatory disorders and cancers, adverse effects, and avenues of further research. Methods: Structured research was carried out including Pub med, Science direct Medline, Research Gate and Google Scholar to find all articles published on helenalin. Various keywords used were “helenalin”, “Arnica”, “cancer”, “anti-inflammatory”, “cardiovascular”, “IBD”, “pharmacokinetics” etc. The aim of the review was to find out the problem prevailing in the data published to date which will help the researchers to investigate the molecule clinically. Results: Seventy articles are included in the review. Helenalin is found to cure chronic conditions like rheumatoid arthritis, ulcers and malignancies like stomach, colon, breast, larynx, lung and skin cancers via multiple mechanisms. These diseases do not proceed via a unilateral pathway. So, it can be a useful molecule to treat numerous diseases. Conclusion: This review article will help us to systemically analyze the wealth of information concerning the medicinal properties of helenalin and to recognize the gaps which have vetoed its pervasive application in the medical community.

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