Helenalin: An Anti-Inflammatory and Anti-Neoplastic Agent: A Review

2020 ◽  
Vol 16 (8) ◽  
pp. 1134-1146
Author(s):  
Priyanka Kriplani ◽  
Kumar Guarve ◽  
Uttam S. Baghel
Keyword(s):  
Rheumatoid Arthritis ◽  
Adverse Effects ◽  
Chronic Conditions ◽  
Review Article ◽  
Google Scholar ◽  
Medical Community ◽  
Inflammatory Agent ◽  
Skin Cancers ◽  
Medicinal Properties ◽  
Anti Inflammatory

Objective: Helenalin is a natural anti-inflammatory agent that is proving its efficacy to treat various medical conditions. Though many plants are proving their effectiveness but their mechanisms are still not well understood. The objective of the review is to summarize various mechanisms of helenalin to treat inflammatory disorders and cancers, adverse effects, and avenues of further research. Methods: Structured research was carried out including Pub med, Science direct Medline, Research Gate and Google Scholar to find all articles published on helenalin. Various keywords used were “helenalin”, “Arnica”, “cancer”, “anti-inflammatory”, “cardiovascular”, “IBD”, “pharmacokinetics” etc. The aim of the review was to find out the problem prevailing in the data published to date which will help the researchers to investigate the molecule clinically. Results: Seventy articles are included in the review. Helenalin is found to cure chronic conditions like rheumatoid arthritis, ulcers and malignancies like stomach, colon, breast, larynx, lung and skin cancers via multiple mechanisms. These diseases do not proceed via a unilateral pathway. So, it can be a useful molecule to treat numerous diseases. Conclusion: This review article will help us to systemically analyze the wealth of information concerning the medicinal properties of helenalin and to recognize the gaps which have vetoed its pervasive application in the medical community.

Herbal Products for Common Auto-Inflammatory Disorders - Novel Approaches

2018 ◽  
Vol 21 (3) ◽  
pp. 161-174 ◽  
Author(s):  
Shanoo Suroowan ◽  
Fawzi Mahomoodally
Keyword(s):  
Adverse Effects ◽  
Chronic Conditions ◽  
Herbal Medicines ◽  
Review Article ◽  
Herbal Products ◽  
Inflammatory Disorders ◽  
Treatment Regimens ◽  
Synthetic Agents ◽  
Unique Approach ◽  
Novel Approaches

Background: Common auto-inflammatory disorders (CAIDs) constitute a wide array of ailments ranging from acute allergies to chronic conditions. Globally, CAIDs remain one of the leading causes of disability and morbidity. Despite playing a leading therapeutic role, the vast profusion of anti-inflammatory synthetic agents have not been able to fully resolve a panoply of CAIDs. Additionally, contemporary synthetic therapy approaches remain bounded by a wide array of limitations essentially being adverse effects and unaffordable costs. In this advent, the use of herbal products provides an interesting avenue to explore in view of developing such treatment regimens. Objective: This review article endeavors to highlight potential herbal products and isolated phytochemicals which can be of benefit in the prophylaxis, management, and treatment alongside avoiding the relapse of CAIDs. Conclusion: This review article has highlighted that herbals, herbal products, and isolated metabolites hold a huge potential in the prophylaxis, management, and treatment of CAIDs. Herbals can act on various targets involved in the pathogenesis of inflammatory disorders. In addition, novel approaches for the management of CAIDs are numerous. Indeed, nanoparticles loaded with phytochemicals have been developed to specifically target the colon for IBD treatment. In silico approaches using herbals also offer unlimited avenues to decipher new pharmacophores. Investigating the potential of polyherbal formulations is another unique approach which can be investigated. Given the inefficacy of conventional medicines, the concomitant use of conventional and herbal medicines can also be explored.

Fenbufen, a New Non-Steroidal Anti-Inflammatory Agent in Rheumatoid Arthritis, its Efficacy and Toxicity

1980 ◽  
Vol 8 (5) ◽  
pp. 333-338 ◽  
Author(s):  
Alfred Becker ◽  
Rex T Hoffmeister
Keyword(s):  
Rheumatoid Arthritis ◽  
Side Effects ◽  
Half Life ◽  
Butanoic Acid ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Inflammatory Agent ◽  
Anti Inflammatory ◽  
Mild Toxicity

Fenbufen, a new butanoic acid derivative with anti-inflammatory properties, was evaluated in an open-label study. It was found that fenbufen was an effective anti-inflammatory agent with tolerable and acceptable potential side-effects. Its advantages appeared to be its long clinical half-life and relatively mild toxicity and/or allergic response.

▾Tenoxicam - yet another NSAID

1989 ◽  
Vol 27 (19) ◽  
pp. 73-74
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
Adverse Effects ◽  
Inflammatory Drug ◽  
Relative Safety ◽  
Anti Inflammatory

Tenoxicam (Mobiflex) is a new non-steroidal anti-inflammatory drug (NSAID) being promoted by two major companies, Roche and Glaxo (Duncan Flockhart), which have hitherto had no products in this field. It is licensed for “the relief of pain and inflammation in osteoarthritis and rheumatoid arthritis”. We have previously highlighted the balance between efficacy and risk of serious adverse effects for NSAIDs;1 the relative safety of a new NSAID is particularly difficult to quantify because of the few patients studied in clinical trials. Does tenoxicam offer any features that justify introduction of yet another NSAID?

Diftalone: A New Non-Steroidal Anti-Inflammatory Agent: Comparative Study with Phenylbutazone in the Treatment of Rheumatoid Arthritis

1977 ◽  
Vol 5 (1) ◽  
pp. 18-25 ◽  
Author(s):  
F Chalem ◽  
P Farias ◽  
H Lizarazo ◽  
P Peña
Keyword(s):  
Rheumatoid Arthritis ◽  
Side Effects ◽  
Comparative Study ◽  
Clinical Improvement ◽  
Laboratory Tests ◽  
Double Blind Study ◽  
Double Blind ◽  
Treatment Groups ◽  
Inflammatory Agent ◽  
Anti Inflammatory

A double-blind study was carried out to compare the effectiveness and tolerability of diftalone and phenylbutazone in thirty patients with classical or definite rheumatoid arthritis, randomly distributed between the two treatment groups. Both drugs were administered according to a progressively decreasing daily dosage schedule: 1,000 mg during the 1st week; 750 mg the 2nd week and 500 mg from the 3rd week on for diftalone; 400 mg, 300 mg, and 200 mg daily for the 1st, 2nd and from the 3rd week on respectively for phenylbutazone. The study lasted twelve weeks. The clinical controls and laboratory tests were performed weekly up to the 8th week, while the final evaluation was made at the end of the 3rd month. Twelve patients in the group receiving diftalone and fourteen in the phenylbutazone group completed the trial. Clinical improvement was observed in both groups. Effectiveness was somewhat more evident in the diftalone group. Tolerability was acceptable for both drugs, although the diftalone patients showed less frequent and intense side-effects than those treated with phyenylbutazone. No significant differences were found as regards the laboratory parameters, except a significant fall of the E.S.R. (p < 0·05) in the diftalone group. Diftalone seems to be an effective and safe anti-inflammatory agent in the treatment of rheumatoid arthritis.

scholarly journals Naproxen. A new non-hormonal anti-inflammatory agent. Studies in rheumatoid arthritis.

1974 ◽  
Vol 33 (1) ◽  
pp. 12-19 ◽  
Author(s):  
H F Hill ◽  
A G Hill ◽  
A G Mowat ◽  
B M Ansell ◽  
J A Mathews ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Inflammatory Agent ◽  
Anti Inflammatory

The consequences of using widely available non-steroidal anti-inflammatory drugs (NSAIDs)

2018 ◽  
Vol 21 (3) ◽  
Author(s):  
Joanna Synoweć ◽  
Katarzyna Pogorzelczyk ◽  
Marlena Robakowska ◽  
Daniel Ślęzak ◽  
Przemysław Żuratyński ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chronic Pain ◽  
Gastrointestinal Tract ◽  
Adverse Effects ◽  
Respiratory Diseases ◽  
Easy Access ◽  
The World ◽  
Wide Availability ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used throughout the world due to their wide availability and a broad range of effects. Patients have easy access to these drugs in pharmacies and cosmetic shops, with the latter ones rarely having personnel qualified to provide advice on dosage. NSAIDs are usually administered to manage pain, fever and inflammation. They are used for conditions such as rheumatoid arthritis, oropharyngeal inflammations or in the treatment of chronic pain. Nevertheless, they are most often used for home treatment of common conditions, such as cold. However, NSAIDs can cause multiple adverse effects. They adversely affect the gastrointestinal tract, contribute to hypertension, show hepatotoxic properties, exacerbate respiratory diseases, induce allergies and haematological complications. Adverse effects may occur both due to overdose, as well as independently of the dose. The aim of this review is to present adverse effects of nonsteroidal anti-inflammatory drugs, the awareness of Poles concerning the use of NSAIDs, as well as measures to be taken in order to limit the adverse health consequences of the use of these drugs.

scholarly journals Phytotherapeutic properties of the Caesalpinia genus present in the Caatinga biome

2021 ◽  
Vol 14 (6) ◽  
pp. 31-36
Author(s):  
Kaline Soares Da Silva ◽  
Fernanda Granja da Silva Oliveira ◽  
Paulo Henrique Oliveira De Miranda ◽  
Eduarda Santos de Santana ◽  
Zion Nascimento De Souza ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Literature Review ◽  
Herbal Medicines ◽  
Chemical Study ◽  
Google Scholar ◽  
Easy Access ◽  
Caatinga Biome ◽  
Medicinal Properties ◽  
Anti Inflammatory

The society enjoys a lot of medicinal plants due to their easy access and also due to the effectiveness of their use, currently, the popular use of these plants has been awakening the pharmaco-chemical study of their properties. Brazil with its great biodiversity worldwide, has an endemic biome, the Caatinga has a great diversity of plants with medicinal properties. The present work aimed to unite plants of the Caesalpinia genus with medicinal properties, through a literature review. The research was carried out on the electronic databases Google Scholar, Pubmed and Scielo using the following descriptors: “Plantas Medicinais”, medicinal plants, gênero Caesalpinia, Caesalpinia genus , fitoterápicos, herbal medicines, Caatinga. In total, 142 articles were found, of which 44 were included, with the characteristics of being plants with medicinal properties of the Caesalpinia genus in the Caatinga biome. After surveying the works found, it was possible to identify the following species, Caesalpinia pyramidalis Tul, Caesalpinia Ferrea Mart. Caesalpinia bracteosa Tul, found in the Caatinga biome. Each studied species had particular characteristics, having in common some anti-inflammatory properties, are studied by some researchers and are effective in their popular use.

scholarly journals Lyprinol—Is It a Useful Anti-Inflammatory Agent?

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Sheila A. Doggrell
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
New Zealand ◽  
Animal Models ◽  
Design Problems ◽  
Inflammatory Agent ◽  
Definite Answer ◽  
Anti Inflammatory ◽  
Small Benefit ◽  
The Web

The New Zealand green lipped mussel preparation Lyprinol is available without a prescription from a supermarket, pharmacy or Web. The Food and Drug Administration have recently warned Lyprinol USA about their extravagant anti-inflammatory claims for Lyprinol appearing on the web. These claims are put to thorough review. Lyprinol does have anti-inflammatory mechanisms, and has anti-inflammatory effects in some animal models of inflammation. Lyprinol may have benefits in dogs with arthritis. There are design problems with the clinical trials of Lyprinol in humans as an anti-inflammatory agent in osteoarthritis and rheumatoid arthritis, making it difficult to give a definite answer to how effective Lyprinol is in these conditions, but any benefit is small. Lyprinol also has a small benefit in atopic allergy. As anti-inflammatory agents, there is little to choose between Lyprinol and fish oil. No adverse effects have been reported with Lyprinol. Thus, although it is difficult to conclude whether Lyprinol does much good, it can be concluded that Lyprinol probably does no major harm.

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