scholarly journals Bone material strength index as measured by impact microindentation in vivo is altered in patients with primary hyperparathyroidism

Bone Reports ◽  
2020 ◽  
Vol 13 ◽  
pp. 100630
Author(s):  
Manuela Schoeb ◽  
Elizabeth M. Winter ◽  
Abbey Schepers ◽  
Marieke Snel ◽  
Natasha M. Appelman-Dijkstra
Keyword(s):  
Primary Hyperparathyroidism ◽  
Material Strength ◽  
Strength Index ◽  
Bone Material ◽  
Bone Material Strength ◽  
Impact Microindentation

scholarly journals Bone Material Strength index as measured by Impact Microindentation is low in Patients with Primary Hyperparathyroidism

2021 ◽  
Author(s):  
Manuela Schoeb ◽  
Elizabeth M Winter ◽  
Maria A Sleddering ◽  
Mirjam A Lips ◽  
Abbey Schepers ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Material Properties ◽  
Fragility Fractures ◽  
Material Strength ◽  
Strength Index ◽  
Mineral Density ◽  
Bone Material ◽  
Bone Material Properties ◽  
Bone Material Strength ◽  
Impact Microindentation

Abstract Context In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at peripheral sites but also at the spine, and fractures occur at higher BMD values than expected. We hypothesized that components of bone quality other than BMD are affected in PHPT as well. Objective To evaluate bone material properties using Impact Microindentation (IMI) in PHPT patients. Methods In this cross-sectional study, Bone Material Strength index (BMSi) was measured by IMI at the midshaft of the tibia in 37 patients with PHPT (28 women), 11 of whom had prevalent fragility fractures, and 37 euparathyroid controls (28 women) matched for age, gender and fragility fracture status. Results Mean age of PHPT patients and controls was 61.8±13.3 and 61.0±11.8 years, respectively, p=0.77. Calcium and PTH levels were significantly higher in PHPT patients but BMD at the lumbar spine (0.92±0.15 vs 0.89±0.11, p=0.37) and the femoral neck (0.70±0.11 vs 0.67±0.07, p=0.15) were comparable between groups. BMSi however was significantly lower in PHPT patients than in controls (78.2±5.7 vs 82.8±4.5, p<0.001). In addition, BMSi was significantly lower in 11 PHPT patients with fragility fractures than in the 26 PHPT patients without fragility fractures (74.7±6.0 vs 79.6±5.0, p=0.015). Conclusion Our data indicate that bone material properties are altered in PHPT patients and most affected in those with prevalent fractures. IMI might be a valuable additional tool in the evaluation of bone fragility in patients with PHPT.

scholarly journals Bone material strength index as measured by impact microindentation is altered in patients with acromegaly

2017 ◽  
Vol 176 (3) ◽  
pp. 339-347 ◽  
Author(s):  
F Malgo ◽  
N A T Hamdy ◽  
T J Rabelink ◽  
H M Kroon ◽  
K M J A Claessen ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Tissue Level ◽  
Material Strength ◽  
Strength Index ◽  
Mineral Density ◽  
Cross Sectional ◽  
Bone Material ◽  
Normal Bone Mineral Density ◽  
Bone Material Strength ◽  
Impact Microindentation

Objective Acromegaly is a rare disease caused by excess growth hormone (GH) production by the pituitary adenoma. The skeletal complications of GH and IGF-1 excess include increased bone turnover, increased cortical bone mass and deteriorated microarchitecture of trabecular bone, associated with a high risk of vertebral fractures in the presence of relatively normal bone mineral density (BMD). We aimed to evaluate tissue-level properties of bone using impact microindentation (IMI) in well-controlled patients with acromegaly aged ≥18 years compared to 44 controls from the outpatient clinic of the Centre for Bone Quality. Design and methods In this cross-sectional study, bone material strength index (BMSi) was measured in 48 acromegaly patients and 44 controls with impact microindentation using the osteoprobe. Results Mean age of acromegaly patients (54% male) was 60.2 years (range 37.9–76.5), and 60.5 years (range 39.8–78.6) in controls (50% male). Patients with acromegaly and control patients had comparable BMI (28.2 kg/m2 ± 4.7 vs 26.6 kg/m2 ± 4.3, P = 0.087) and comparable BMD at the lumbar spine (1.04 g/cm2 ± 0.21 vs 1.03 g/cm2 ± 0.13, P = 0.850) and at the femoral neck (0.84 g/cm2 ± 0.16 vs 0.80 g/cm2 ± 0.09, P = 0.246). BMSi was significantly lower in acromegaly patients than that in controls (79.4 ± 0.7 vs 83.2 ± 0.7; P < 0.001). Conclusion Our data indicates that tissue-level properties of cortical bone are significantly altered in patients with controlled acromegaly after reversal of long-term exposure to pathologically high GH and IGF-1 levels. Our findings also suggest that methods other than DXA should be considered to evaluate bone fragility in patients with acromegaly.

scholarly journals Bone Material Strength Index as Measured by Impact Microindentation in Postmenopausal Women With Distal Radius and Hip Fractures

2017 ◽  
Vol 33 (4) ◽  
pp. 621-626 ◽  
Author(s):  
Tamara D Rozental ◽  
Kempland C Walley ◽  
Serkalem Demissie ◽  
Signe Caksa ◽  
Adriana Martinez-Betancourt ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Distal Radius ◽  
Hip Fractures ◽  
Material Strength ◽  
Strength Index ◽  
Bone Material ◽  
Bone Material Strength ◽  
Impact Microindentation

Significant correlation of bone material strength index as measured by the OsteoProbe with Vickers and Rockwell hardness

2020 ◽  
Vol 91 (8) ◽  
pp. 084102
Author(s):  
Franklin S. Ly ◽  
Alexander Proctor ◽  
Kevin Hoffseth ◽  
Henry T. Yang ◽  
Paul K. Hansma
Keyword(s):  
Material Strength ◽  
Rockwell Hardness ◽  
Strength Index ◽  
Bone Material ◽  
Bone Material Strength

MO567PILOT STUDY OF BONE RESISTANCE MEASURED IN VIVO BY IMPACT MICROINDENTATION IN KIDNEY TRANSPLANTATION

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Maria Jesus Lloret ◽  
Cristina Canal ◽  
Silvana Di Gregorio ◽  
Carmen Facundo Molas ◽  
Ana Vila Santandreu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Trabecular Bone Score ◽  
Individual Risk ◽  
Control Group ◽  
Material Strength ◽  
Bone Material Strength ◽  
History Of ◽  
The Individual ◽  
Impact Microindentation

Abstract Background and Aims Impact microindentation (IMI) is a new technique that measures bone material strength (BMS). Results are expressed as a BMS index (BMSi) which represents the ratio between the IMI distance [penetration of the needle-probe in patient’s bone (mid-shaft tibia)] versus a reference material (polimethylmethacrylate). Method Observational, prospective, single-center study. Baseline IMI (Osteoprobe®, Active Life Scientific, USA) and bone densitometry (iDXA, Lunar Health Care GE) were performed and data collected in the peritransplantation period of kidney transplant (KT) patients from May 2019 to May 2020, following our current clinical bone and transplant protocols. Based on the individual risk of fracture and current Spanish Society of Rheumathology/Nephrology guidelines, antirresorptive treatment (bisphosphonates or denosumab) was added on top of calcium and vitamin D supplements. We hereby present preliminary results of the control IMI performed 6 months after KT. Results Baseline IMI was performed in 45 patients, 62% men, 56±14 y/o, and a BMI of 24.9±3.5 kg/m2, reasonably controlled for classical serum bone mineral parameters. 70% were on dialysis prior to KT, 20% were diabetic, and 33.3% of women suffered from early menopause. 15.9% had a history of previous fragility fracture, 13% had a parent history of hip fracture, and 14% fell more than twice during the last year. Mean baseline FRAX® (https://www.sheffield.ac.uk/FRAX/tool.aspx?lang=sp) for a major osteoporotic fracture and hip were 4.3% and 2.3%, respectively. Baseline lumbar, femoral neck, hip and ultradistal radius DXA T-score were respectively -0.9, -1.7, -1.5, -2.0 SD. Mean BMSi was 78.5±7.6. Osteopenic/osteoporotic patients had a significantly lower BMSi than those who were not (76.3 vs 83; r = 0.37; p = 0.012). A statistically significant positive correlation was observed between BMSi and the trabecular bone score [(TBS), r = 0.346 ; p = 0.036). On a visual-analogic scale of pain, puncture was rated on average 1.1±1.6 over 10 (82% 0-2). 37.2% of patients began bisphosphonates (alendronic acid) and 9.3% denosumab. Control IMI was performed at 6 months in 24 patients, with a mean BMSi of 76.9±10.5. Mean difference between baseline and 6 months BMSi in this subgroup was 1.18±11.5. The group of patients treated with antiresorptives showed on average an increase in BMSi at 6 months, compared with a decrease in the control group (+5.2 vs -5.3; p = 0.054). Conclusion IMI is a technique with excellent tolerance that may offer complementary information on bone quality in the global assessment of bone resistance. IMI may allow the detection of EARLY changes in bone resistance in corticosteroid-treated KT patients with/without antiresorptives added to prophylactic treatment with calcium and vitamin D.

Discrepancy between bone density and bone material strength index in three siblings with Camurati-Engelmann disease

2017 ◽  
Vol 28 (12) ◽  
pp. 3489-3493 ◽  
Author(s):  
S. Herrera ◽  
R. Soriano ◽  
X. Nogués ◽  
R. Güerri-Fernandez ◽  
D. Grinberg ◽  
...  
Keyword(s):  
Bone Density ◽  
Material Strength ◽  
Strength Index ◽  
Bone Material ◽  
Bone Material Strength ◽  
Engelmann Disease

scholarly journals Applications of a New Handheld Reference Point Indentation Instrument Measuring Bone Material Strength

2013 ◽  
Vol 7 (4) ◽  
Author(s):  
Connor Randall ◽  
Daniel Bridges ◽  
Roberto Guerri ◽  
Xavier Nogues ◽  
Lluis Puig ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Reference Point ◽  
Material Strength ◽  
Bone Material ◽  
Reference Point Indentation ◽  
Instrument Measuring ◽  
Bone Material Strength ◽  
Large Animals

A novel, hand-held Reference Point Indentation (RPI) instrument, measures how well the bone of living patients and large animals resists indentation. The results presented here are reported in terms of Bone Material Strength, which is a normalized measure of how well the bone resists indentation, and is inversely related to the indentation distance into the bone. We present examples of the instrument's use in: (1) laboratory experiments on bone, including experiments through a layer of soft tissue, (2) three human clinical trials, two ongoing in Barcelona and at the Mayo Clinic, and one completed in Portland, OR, and (3) two ongoing horse clinical trials, one at Purdue University and another at Alamo Pintado Stables in California. The instrument is capable of measuring consistent values when testing through soft tissue such as skin and periosteum, and does so handheld, an improvement over previous Reference Point Indentation instruments. Measurements conducted on horses showed reproducible results when testing the horse through tissue or on bare bone. In the human clinical trials, reasonable and consistent values were obtained, suggesting the Osteoprobe® is capable of measuring Bone Material Strength in vivo, but larger studies are needed to determine the efficacy of the instrument's use in medical diagnosis.

scholarly journals Associations between Bone Material Strength Index, Calcaneal Quantitative Ultrasound and Bone Mineral Density in Men

2020 ◽  
Author(s):  
Pamela Rufus-Membere ◽  
Kara L Holloway-Kew ◽  
Adolfo Diez-Perez ◽  
Mark A Kotowicz ◽  
Julie A Pasco
Keyword(s):  
Quantitative Ultrasound ◽  
Broadband Ultrasound Attenuation ◽  
Positive Association ◽  
Material Strength ◽  
Strength Index ◽  
Mineral Density ◽  
Bone Material ◽  
Skeletal Site ◽  
Bone Material Strength ◽  
Calcaneal Quantitative Ultrasound

Abstract Objectives Impact microindentation (IMI) measures bone material strength index (BMSi) in vivo. This study investigated how IMI is associated with calcaneal quantitative ultrasound and bone densitometry parameters in men. Methods BMSi was measured on the tibial plateau using the OsteoProbe in 377 men (ages 33-96yr) from the Geelong Osteoporosis Study. Broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (SI) were assessed at the calcaneus using an ultrasonometer. Areal BMD was measured at several skeletal sites using dual-energy X-ray absorptiometry. Linear associations between parameters were tested using Pearson’s correlation. Multivariable regression techniques were used to determine associations between BMSi and other measures of bone, independent of confounders. Results BMSi was negatively correlated with age (r = -0.171, p=0.001), weight (r = -0.100, p=0.052) and body mass index (r = -0.187, p=0.001), and positively with height (r = +0.109, p=0.034). There was some evidence to support a positive association between BMSi and BUA (β=0.052, p=0.037), SOS (β=0.013, p=0.144) and SI (β=0.036, p=0.051). After age adjustment, this association was attenuated. No correlations were observed between BMSi and BMD at any skeletal site (r-values ranged from -0.006 to +0.079, all p&gt;0.13). Conclusion There was a small positive association between BMSi and QUS parameters, which were not independent of age. No associations were detected between BMSi and BMD. This suggests that BMSi and QUS are capturing common age-dependent properties of bone. Further research on the utility of IMI alone and complementary to conventional bone testing methods for predicting fracture risk is warranted.

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