scholarly journals Bone Material Strength as Measured by Microindentation In Vivo Is Decreased in Patients With Fragility Fractures Independently of Bone Mineral Density

2015 ◽  
Vol 100 (5) ◽  
pp. 2039-2045 ◽  
Author(s):  
Frank Malgo ◽  
Neveen A. T. Hamdy ◽  
Socrates E. Papapoulos ◽  
Natasha M. Appelman-Dijkstra
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Fragility Fractures ◽  
Material Strength ◽  
Mineral Density ◽  
Bone Material ◽  
Bone Material Strength

MO576ASSOCIATION OF BONE MATERIAL STRENGTH WITH BONE DENSITY IN PATIENTS WITH END-STAGE RENAL DISEASE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Matilda Johnsson ◽  
Abdul Rashid Tony Qureshi ◽  
Magdalena Jankowska ◽  
Bengt Lindholm ◽  
Mathias Haarhaus
Keyword(s):  
Bone Mineral Density ◽  
Alkaline Phosphatase ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Material Strength ◽  
Mineral Density ◽  
Bone Material ◽  
Bone Material Strength ◽  
Stage Renal Disease

Abstract Background and Aims Patients with end-stage renal disease (ESRD) have an increased risk of skeletal complications, including an increased fracture risk, which is only partially identified by determination of bone mineral density (BMD). Experimentally, the complex bone-and mineral disorders in ESRD cause disturbances of bone material properties, but these have not been studied in vivo. Determination of bone material strength index (BMSi) by reference point indentation (RPI) is a novel method to determine bone material quality in vivo and can identify patients at increased fracture risk, even in the presence of normal BMD. We determined BMSi in ESRD patients and investigated its association with BMD and serum markers of mineral metabolism. Method 15 Adult patients with ESRD, scheduled for a living-donor kidney transplantation, were included in this cross-sectional study. Laboratory analyses included calcium, phosphate, PTH 1-84 and alkaline phosphatase. BMSi was determined by RPI with the OsteoProbe RUO in the tibia. Bone mineral density was measured by dual X-ray absorptiometry. Results Patients with bone mineral strenght index above median had higher bone mineral density of the right hip and total body than patients below median (p = 0.04). Alkaline phosphatase was lower in patients with BMSi below the median (47 (35-71) U/L vs. 103 (53-318) U/L, p = 0.009). There was a trend towards a significant relationship between length and BMSi (p = 0.09). Conclusion We identified for the first time an association of BMSi with BMD and alkaline phosphatase in patients with ESRD. Our findings of an association of BMSi with BMD are in accordance with findings in other populations with increased fracture risk.

scholarly journals Bone Material Strength index as measured by Impact Microindentation is low in Patients with Primary Hyperparathyroidism

2021 ◽  
Author(s):  
Manuela Schoeb ◽  
Elizabeth M Winter ◽  
Maria A Sleddering ◽  
Mirjam A Lips ◽  
Abbey Schepers ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Material Properties ◽  
Fragility Fractures ◽  
Material Strength ◽  
Strength Index ◽  
Mineral Density ◽  
Bone Material ◽  
Bone Material Properties ◽  
Bone Material Strength ◽  
Impact Microindentation

Abstract Context In primary hyperparathyroidism (PHPT) bone mineral density (BMD) is typically decreased in cortical bone and relatively preserved in trabecular bone. An increased fracture rate is observed however not only at peripheral sites but also at the spine, and fractures occur at higher BMD values than expected. We hypothesized that components of bone quality other than BMD are affected in PHPT as well. Objective To evaluate bone material properties using Impact Microindentation (IMI) in PHPT patients. Methods In this cross-sectional study, Bone Material Strength index (BMSi) was measured by IMI at the midshaft of the tibia in 37 patients with PHPT (28 women), 11 of whom had prevalent fragility fractures, and 37 euparathyroid controls (28 women) matched for age, gender and fragility fracture status. Results Mean age of PHPT patients and controls was 61.8±13.3 and 61.0±11.8 years, respectively, p=0.77. Calcium and PTH levels were significantly higher in PHPT patients but BMD at the lumbar spine (0.92±0.15 vs 0.89±0.11, p=0.37) and the femoral neck (0.70±0.11 vs 0.67±0.07, p=0.15) were comparable between groups. BMSi however was significantly lower in PHPT patients than in controls (78.2±5.7 vs 82.8±4.5, p<0.001). In addition, BMSi was significantly lower in 11 PHPT patients with fragility fractures than in the 26 PHPT patients without fragility fractures (74.7±6.0 vs 79.6±5.0, p=0.015). Conclusion Our data indicate that bone material properties are altered in PHPT patients and most affected in those with prevalent fractures. IMI might be a valuable additional tool in the evaluation of bone fragility in patients with PHPT.

scholarly journals DXA parameters, Trabecular Bone Score (TBS) and Bone Mineral Density (BMD), in fracture risk prediction in endocrine-mediated secondary osteoporosis

Endocrine ◽  
2021 ◽  
Author(s):  
Enisa Shevroja ◽  
Francesco Pio Cafarelli ◽  
Giuseppe Guglielmi ◽  
Didier Hans
Keyword(s):  
Bone Mineral Density ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Trabecular Bone Score ◽  
Bone Microarchitecture ◽  
Fragility Fractures ◽  
Endocrine Disorders ◽  
Mineral Density ◽  
Increased Risk

AbstractOsteoporosis, a disease characterized by low bone mass and alterations of bone microarchitecture, leading to an increased risk for fragility fractures and, eventually, to fracture; is associated with an excess of mortality, a decrease in quality of life, and co-morbidities. Bone mineral density (BMD), measured by dual X-ray absorptiometry (DXA), has been the gold standard for the diagnosis of osteoporosis. Trabecular bone score (TBS), a textural analysis of the lumbar spine DXA images, is an index of bone microarchitecture. TBS has been robustly shown to predict fractures independently of BMD. In this review, while reporting also results on BMD, we mainly focus on the TBS role in the assessment of bone health in endocrine disorders known to be reflected in bone.

93 Does Spinal Bone Mineral Density Predict An Absolute 10 Year Probability of Sustaining A Major Osteoporotic Fracture

2021 ◽  
Vol 50 (Supplement_1) ◽  
pp. i12-i42
Author(s):  
A Nandi ◽  
N Obiechina ◽  
A Timperley ◽  
F Al-Khalidi
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Osteoporotic Fracture ◽  
Negative Correlation ◽  
Pearson Correlation ◽  
Fragility Fractures ◽  
Mineral Density ◽  
Major Osteoporotic Fracture ◽  
T Score ◽  
The Mean

Abstract Introduction Spine and hip bone mineral density (BMD) have previously been shown to predict the risk of sustaining future fractures. Although these have been shown in population studies, there is a paucity of trials looking at the relationship between BMD and 10 year probability of major osteoporotic fractures (Using FRAX UK without BMD) in patients with previous fragility fractures. Aims To evaluate the correlation between spinal T-score and an absolute 10 year probability of sustaining a major osteoporotic fracture (using FRAX without BMD) in patients with prior fragility fractures. Methods A retrospective cross-sectional analysis of 202 patients (29 males and 173 females) with prior fragility fractures attending a fracture prevention clinic between January and August 2019 was performed. Patients with pathological and high impact traumatic fractures were excluded. The BMD at the spine was determined using the lowest T-score of the vertebrae from L1 to L4. Using the FRAX (UK) without BMD, the absolute 10 year probability of sustaining a major osteoporotic fracture was calculated for each patient. Statistical analysis was performed using SPSS 26 software. Results The mean T-score at the spine was −1.15 (SD +/− 1.90) for all patients, −0.68 (SD +/− 0.45) for males and − 1.23 (SD +/− 0.14) for females. The mean FRAX score without BMD for major osteoporotic fracture was 18.5% (SD +/− 8.84) for all patients, 11.41% (SD +/−0.62) and 19.7% (SD +/−0.68) for males and females respectively. Pearson correlation coefficient showed a statistically significant, slightly negative correlation between spinal T- score and the FRAX (UK) without BMD (r = −0.157; p < 0.05). Correlation was not statistically significant when males (r = 0.109; p = 0.59) and females (r = 0.148; p = 0.053) were considered independently. Conclusion In patients with prior fragility fracture spinal BMD has a statistically significant negative correlation with an absolute 10 year probability of sustaining a major osteoporotic fracture.

The effects of ovariectomy on bone mineral density, geometrical, and biomechanical characteristics in the rabbit femur

2010 ◽  
Vol 23 (01) ◽  
pp. 31-36 ◽  
Author(s):  
M. E. Kara ◽  
F. Sevil
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Animal Studies ◽  
Biomechanical Properties ◽  
Mineral Density ◽  
Cross Sectional ◽  
Tomographic Images ◽  
Three Point Bending ◽  
Rabbit Femur

SummaryThe aim of the study was to evaluate the bone mineral density, as well as the biomechanic and morphometric changes in the femur of ovariectomised rabbits.Twenty-four six-month-old New Zealand rabbits were randomly divided into an ovariectomy (n = 12) and a sham (n = 12) group. Six rabbits in each group were euthanatized at eight and 16 weeks after surgery, and the femora were resected. The morphometric data were obtained from tomographic images. Periosteal and endosteal diameters and cortical thickness were measured. Total cross-sectional, cortical and medullary areas were also measured. The bone mineral content, the bone area and the bone mineral density were measured from the proximal, distal and mid-shaft of the femur as well as the total femur by dual energy X-ray absorptiometry. Employing the three-point bending method, the ultimate force, stiffness and work-to-failure were measured. The mechanical data were normalised to obtain intrinsic biomechanical properties such as ultimate stress, elastic modulus, and toughness, all of which are independent of size and shape.The results indicated that the femur was both larger and weaker 16 weeks after surgery in the ovariectomised group. Results also suggest that the rabbit might be a useful animal model for investigation of diseases related to oestrogen loss such as human postmenopausal osteoporosis. However, additional studies with advanced techniques at several time points via in vivo animal studies, and precision and predictability analyses should be designed to standardise the rabbit as a model for osteoporosis.

scholarly journals Assessing bone mineral density in vivo: digitized fluoroscopy and ultrasound

2004 ◽  
Vol 83 (2) ◽  
pp. 207-214 ◽  
Author(s):  
R.H. Fleming ◽  
D. Korver ◽  
H.A. McCormack ◽  
C.C. Whitehead
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density
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