Abnormal Relationships Between Functional Connectivity and Emotional State Point Toward Emotional Dysregulation in Hoarding Disorder

2021 ◽  
Vol 6 (10) ◽  
pp. 945-946
Author(s):  
Rosa Grützmann
Keyword(s):  
Functional Connectivity ◽  
Emotional State ◽  
Emotional Dysregulation ◽  
Hoarding Disorder ◽  
State Point

scholarly journals Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts

2017 ◽  
Vol 30 (2) ◽  
pp. 571-579 ◽  
Author(s):  
Amy Krain Roy ◽  
Randi Bennett ◽  
Jonathan Posner ◽  
Leslie Hulvershorn ◽  
F. Xavier Castellanos ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Emotion Dysregulation ◽  
Cingulate Cortex ◽  
Emotional Dysregulation ◽  
Anterior Cingulate ◽  
Adhd Group ◽  
Healthy Children ◽  
Intrinsic Functional Connectivity ◽  
Midcingulate Cortex ◽  
Temper Outbursts

AbstractSevere temper outbursts (STO) in children are associated with impaired school and family functioning and may contribute to negative outcomes. These outbursts can be conceptualized as excessive frustration responses reflecting reduced emotion regulation capacity. The anterior cingulate cortex (ACC) has been implicated in negative affect as well as emotional control, and exhibits disrupted function in children with elevated irritability and outbursts. This study examined the intrinsic functional connectivity (iFC) of a region of the ACC, the anterior midcingulate cortex (aMCC), in 5- to 9-year-old children with STO (n = 20), comparing them to children with attention-deficit/hyperactivity disorder (ADHD) without outbursts (ADHD; n = 18). Additional analyses compared results to a sample of healthy children (HC; n = 18) and examined specific associations with behavioral and emotional dysregulation. Compared to the ADHD group, STO children exhibited reduced iFC between the aMCC and surrounding regions of the ACC, and increased iFC between the aMCC and precuneus. These differences were also seen between the STO and HC groups; ADHD and HC groups did not differ. Specificity analyses found associations between aMCC–ACC connectivity and hyperactivity, and between aMCC–precuneus iFC and emotion dysregulation. Disruption in aMCC networks may underlie the behavioral and emotional dysregulation characteristic of children with STO.

Increased functional connectivity in gambling disorder correlates with behavioural and emotional dysregulation: Evidence of a role for the cerebellum

2020 ◽  
Vol 390 ◽  
pp. 112668 ◽  
Author(s):  
Tommaso Piccoli ◽  
Giuseppe Maniaci ◽  
Giorgio Collura ◽  
Cesare Gagliardo ◽  
Anna Brancato ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Gambling Disorder ◽  
Emotional Dysregulation

scholarly journals Disrupted socio-emotional neural circuitry in adolescents with borderline personality traits

2018 ◽  
Author(s):  
Kristina Safar ◽  
Julie Sato ◽  
Anthony C. Ruocco ◽  
Marshall S. Korenblum ◽  
Helen O'Halpin ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
A Priori ◽  
Brain Regions ◽  
Borderline Personality ◽  
Emotional Dysregulation ◽  
Anterior Cingulate ◽  
Emotional Expressions ◽  
Angry Face ◽  
Implicit Perception ◽  
Functional Circuitry

Background: Disruptions in fronto-limbic functional connectivity have been reported in adults with borderline personality disorder (BPD), although it is not yet known whether functional circuitry is similarly altered in adolescents with high levels of BPD traits. Methods: Using magnetoencephalography (MEG), the current study investigated task-dependent functional connectivity of eight a priori regions of interest implicated in emotional and social processing during the implicit perception of emotional faces (angry and happy), in 8 female adolescents with BPD traits and 8 age-matched female controls. Results: A network comprising reduced alpha-band phase synchrony during implicit angry face perception was observed in adolescents with BPD traits compared to controls. The network involved brain regions within a fronto-limbic circuit, including connections among bilateral amygdalae and bilateral anterior cingulate cortex (ACC), and additional regions implicated in emotion processing. Conclusions: Results suggest that disrupted interregional oscillatory communication during the perception of threatening emotional expressions might contribute to the socio-emotional dysregulation and maladaptive behavioral responses commonly found in adolescents high in BPD traits. Furthermore, we speculate that this aberrant neural connectivity subserves the emergence of the disorder in adults.

scholarly journals Affective Response During a Sorting Task for Geriatric Hoarding

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 303-304
Author(s):  
Mary Dozier ◽  
Amy Young ◽  
Scott Camilleri
Keyword(s):  
Older Adults ◽  
Self Efficacy ◽  
Positive Emotions ◽  
Emotional State ◽  
Sense Of Self ◽  
Affective Response ◽  
Sorting Task ◽  
Hoarding Disorder ◽  
Average Decrease ◽  
Treatment Gains

Abstract Previous research suggests older adults with hoarding disorder are more likely to express non-fear-based emotions when sorting. The purpose of this study was to examine the emotions expressed by eight rural-dwelling older adults with hoarding disorder when sorting and discarding possessions. The study took place in participants’ homes and involved a 15-minute behavioral sorting task where participants were asked to sort through personal items and make a decision to either keep or discard each item. Participants were asked to rate their Subjective Units of Distress (SUDs) and to state their emotional state prior to the sorting task, every 5 minutes throughout the test, and after completing the task. Four participants did not complete the sorting task due to a lack of a desire to discard objects (e.g., “I want to keep it all”). For the four participants who did complete the task, an average of 53 items were sorted and an average of 24 items were discarded. The average decrease in SUDs from pre-task to post-task was 40. Overall, most participants reported feeling positive emotions before, during, and following the task, with the most commonly reported emotion being joy. This study supports prior research suggesting that not all hoarding is fear based and that older adults may be more motivated by increasing positive associations with sorting and discarding. A focus on increasing patients’ insight and sense of self-efficacy may lead to increased treatment gains for older adults with hoarding disorder.

scholarly journals Distinct large-scale networks are associated with motor and nonmotor symptoms in Parkinson’s disease

2020 ◽  
Author(s):  
Sule Tinaz ◽  
Serageldin Kamel ◽  
Sai S. Aravala ◽  
Mine Sezgin ◽  
Mohamed Elfil ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basal Ganglia ◽  
Functional Connectivity ◽  
Large Scale ◽  
Emotional Dysregulation ◽  
Disease Stage ◽  
Nonmotor Symptoms ◽  
Large Scale Networks ◽  
Brain Data

ABSTRACTParkinson’s disease (PD) is characterized clinically by various motor and nonmotor symptoms. The underlying neuroanatomical correlates of nonmotor symptoms in PD remain poorly understood. We investigated the differences and commonalities in the neuroanatomical correlates 1) between highly prevalent nonmotor features including fatigue, anxiety, depression, and apathy, and 2) between these nonmotor features and motor severity in nondemented subjects with mild PD (Hoehn & Yahr disease stage 2) using structural and functional magnetic resonance imaging. Compared to matched controls, the PD group showed atrophy in the basal ganglia and superior frontal cortex. Motor severity correlated with cortical thinning in frontotemporal regions, as well as with reduced functional connectivity between the frontostriatal and cerebellar networks. The composite nonmotor symptom severity did not show any correlation with the structural brain data, but correlated with reduced functional connectivity in a large-scale network consisting of frontostriatal, parietotemporal, and cerebellar nodes. The individual components of the nonmotor symptoms also mapped onto specific neural networks. Our study shows that motor and nonmotor features in PD are associated with distinct large-scale networks. The basal ganglia and cerebellum are core regions in all of these networks. The abnormal functional connectivity in the nonmotor network seems to be related to cognitive and emotional dysregulation and may have implications for future cognitive decline in PD.

scholarly journals Borderline personality disorder with cocaine dependence: impulsivity, emotional dysregulation and amygdala functional connectivity

2018 ◽  
Author(s):  
Thania Balducci ◽  
Jorge J Gonzalez-Olvera ◽  
Diego Angeles-Valdez ◽  
Isabel Espinoza-Luna ◽  
Eduardo A Garza-Villarreal
Keyword(s):  
Prefrontal Cortex ◽  
Borderline Personality Disorder ◽  
Functional Connectivity ◽  
Personality Disorder ◽  
Medial Prefrontal Cortex ◽  
Resting State Fmri ◽  
Borderline Personality ◽  
Emotional Dysregulation ◽  
Cocaine Dependence ◽  
Opposing Effects

AbstractObjective: Borderline personality disorder (BPD) is present in 19% of cocaine dependence (CD) cases; however, this dual pathology (DP) is poorly understood. We assessed impulsivity, emotional dysregulation (ED) and amygdala functional connectivity in this DP.Methods. We recruited 69 participants divided into 4 groups: DP (n = 20), CD without BPD (n = 19), BPD without CD (n = 10) and healthy controls (HC, n = 20). We used self-reported instruments to measure impulsivity and ED. We acquired resting state fMRI and performed seed-based analyses of functional connectivity (FC) of bilateral amygdalas.Results. BPD and CD factors had opposing effects in impulsivity and ED, as well as on FC between left amygdala and medial prefrontal cortex. For the FC between right amygdala and left insula, the effect of having both disorders was additive, reducing FC strength. Significant FC clusters were correlated with impulsivity and ED.Conclusions. In this preliminary study, we found that clinical scores of DP patients were closer to those of BPD without CD than to those of CD without BPD, while amygdala to medial prefrontal cortex FC patterns in DP patients were closer to HC than expected.

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