The impairment of motor coordination following chronic carbamazepine-levetiracetam adjunctive treatment with evidence of corticocerebellar toxicity in male Wistar rats

2021 ◽  
pp. 147565
Author(s):  
Opeyemi Samson Osuntokun ◽  
Busayo Grace Akingboye ◽  
Gbola Olayiwola ◽  
Taiwo Adekemi Abayomi ◽  
Abiodun Oludele Ayoka
Keyword(s):  
Wistar Rats ◽  
Motor Coordination ◽  
Adjunctive Treatment ◽  
Male Wistar Rats

Hypothalamic–pituitary–testicular axis derangement following chronic phenytoin–levetiracetam adjunctive treatment in male Wistar rats

Andrologia ◽  
2020 ◽  
Vol 52 (11) ◽  
Author(s):  
Opeyemi S. Osuntokun ◽  
Gbola Olayiwola ◽  
Tope G. Atere ◽  
Damilare A. Adekomi ◽  
Kabiru I. Adedokun ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Adjunctive Treatment ◽  
Male Wistar Rats

Curcumin alters motor coordination but not total number of Purkinje cells in the cerebellum of adolescent male Wistar rats

2013 ◽  
Vol 11 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Ginus Partadiredja ◽  
Sutarman ◽  
Taufik Nur Yahya ◽  
Christiana Tri Nuryana ◽  
Rina Susilowati
Keyword(s):  
Purkinje Cells ◽  
Wistar Rats ◽  
Motor Coordination ◽  
Adolescent Male ◽  
Male Wistar Rats

scholarly journals Hepato-toxicological and lipid profile of male Wistar rats following chronic carbamazepine, gabapentin, and carbamazepine-gabapentin adjunctive treatment

2021 ◽  
Vol 9 (3) ◽  
pp. 289-298
Author(s):  
O.S. Osuntokun ◽  
O.O. Oladokun ◽  
K.I. Adedokun ◽  
T.G. Atere ◽  
G. Olayiwola ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Liver Homogenate ◽  
Density Lipoprotein ◽  
Adjunctive Treatment ◽  
Male Wistar Rats ◽  
Level Of Significance ◽  
To Receive ◽  
Chronic Use

Aim: This study evaluated the hepatotoxicity and lipid profiles of male Wistar rats following chronic carbamazepine (CBZ), gabapentin (GBP) and carbamazepine-gabapentin (CBZ+GBP) adjunctive treatment. Methods: Twenty-eight male Wistar rats were randomized into 4 groups (n = 7) to receive daily oral administration of normal saline (0.2ml), or CBZ (25 mg/kg), or GBP (50 mg/kg), or the sub-therapeutic dose of CBZ (12.5 mg/kg) and GBP (25 mg/kg) combination for 56 days. Thereafter, blood and liver homogenate were subjected to biochemical analysis, while liver tissues were processed for the histomorphological investigation. Data were analysed statistically, while p< 0.05 was taken as level of significance. Results: Activities of alanine phosphatase and aspartate aminotransferase significantly increased in the CBZ and CBZ + GBP treated rat.  CBZ and CBZ + GBP treatments increased the plasma concentration of low-density lipoprotein and total cholesterol. The liver concentration of malondialdehyde increased significantly in all the treated groups relative to control. There were severe vascular congestions in theliver of the CBZ treated rats, this was moderate in the GBP and CBZ + GBP treated rats. Conclusion: Chronic use of CBZ may induce hepatotoxicity and lipid profile derangement, GBP and CBZ + GBP adjunctive treatment may be saver than treatment with CBZ. 

Subchronic administration of Parastar insecticide induced behavioral changes and impaired motor coordination in male Wistar rats

2020 ◽  
pp. 1-9
Author(s):  
Antoine Kada Sanda ◽  
Akono Edouard Nantia ◽  
T. F. Pascal Manfo ◽  
Romi T. Toboh ◽  
Roxane Essame Abende ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Motor Coordination ◽  
Behavioral Changes ◽  
Male Wistar Rats

Administration of ethanolic extract of Erythrophleum ivorense (A Chev.) stem bark to male Wistar rats alters brain areas involved in motor coordination, behavior, and memory

2020 ◽  
Vol 253 ◽  
pp. 112650
Author(s):  
Olamide Adebiyi ◽  
Kabirat Adigun ◽  
Oluwabusayo Folarin ◽  
James Olopade ◽  
Funsho Olayemi
Keyword(s):  
Wistar Rats ◽  
Motor Coordination ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Brain Areas ◽  
Coordination Behavior ◽  
Male Wistar Rats

scholarly journals Phenytoin–levetiracetam adjunctive treatment-induced neurotoxicity and deregulation of cholinergic neurotransmission with evidence of neurocognitive impairment in male Wistar rats

2021 ◽  
Vol 57 (1) ◽  
pp. 194-204
Author(s):  
Opeyemi Samson Osuntokun ◽  
Mary Olabisi Aderoju ◽  
Ifeoluwa Esther Adebisi ◽  
Taiwo Adekemi Abayomi ◽  
Olorunfemi Samuel Tokunbo ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Neurocognitive Impairment ◽  
Adjunctive Treatment ◽  
Cholinergic Neurotransmission ◽  
Male Wistar Rats

scholarly journals Sub-acute evaluation of artesunate, amodiaquine and their combination on muscular coordination and morphology of the cerebellum of Wistar rats

2020 ◽  
Vol 14 (5) ◽  
pp. 1498-1510
Author(s):  
AbdulGafar N. Popoola ◽  
Innocent O. Imosemi
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Wistar Rats ◽  
Motor Coordination ◽  
Artemisinin Combination Therapy ◽  
Acute Effect ◽  
Water Control ◽  
Oxidative Markers ◽  
Male Wistar Rats ◽  
Immunohistochemical Studies

Artemisinin Combination Therapy (ACT) is currently the best choice for the treatment of malaria. Artesunate-amodiaquine combination is one of the most commonly used ACTs in Nigeria with a very potent efficacy but not without side effects involving motor coordination. Currently, there is dearth of information on its sub-acute effect on the cerebellum. This study investigated the sub-acute effects of artesunate (AS), amodiaquine (AQ) and artesunate + amodiaquine combination (AS+AQ) on the motor coordination, oxidative markers and morphology of the cerebellum of adult Wistar rats. Forty adult male Wistar rats were randomly divided into 4 groups, n=10. The rats were administered orally for 3 days, distilled water (control, CT), 4 mg/kg body weight AS, 10 mg/kg body weight AQ and 4 mg/kg AS + 10 mg/kg AQ. Rats were weighed, assessed for motor coordination and sacrificed on day 15. Brain tissues were excised and some cerebella preserved for oxidative stress and antioxidants while others were fixed in 10% NBF for histological and immunohistochemical studies. Results showed significant decreased body weight of the AQ group compared to the CT; decreased time of fore limb grip in the AS and AQ groups compared with the CT. Test groups showed increased LPO and NO, and lower levels of SOD, CAT and GSH compared with the control. Artesunate and AQ had significantly reduced number of Purkinje cells, AQ and AS caused increased astrocyte population and increased expression of iNOS. Sub-acute studies of Wistar rats treated with artesunate, amodiaquine and their  combination induced oxidative stress, reduced their motor function and impaired morphology of the cerebellum. Keywords: Artesunate, amodiaquine, behaviour, cerebellum, histology, immunohistochemistry.

scholarly journals Assessment of the biomarkers of hepatotoxicity following carbamazepine, levetiracetam, and carbamazepine-levetiracetam adjunctive treatment in male Wistar rats

2021 ◽  
Vol 8 ◽  
pp. 592-598
Author(s):  
Opeyemi Samson Osuntokun ◽  
Ademola Adeniyi Babatunde ◽  
Gbola Olayiwola ◽  
Tope Gafar Atere ◽  
Olayemi Olutobi Oladokun ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Adjunctive Treatment ◽  
Male Wistar Rats

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

2020 ◽  
pp. 1-6 ◽  
Author(s):  
Masoud Nasiri ◽  
Saja Ahmadizad ◽  
Mehdi Hedayati ◽  
Tayebe Zarekar ◽  
Mehdi Seydyousefi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Wistar Rats ◽  
Enzymatic Antioxidants ◽  
Acute Response ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
Exercise Induced ◽  
And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

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