scholarly journals Phenytoin–levetiracetam adjunctive treatment-induced neurotoxicity and deregulation of cholinergic neurotransmission with evidence of neurocognitive impairment in male Wistar rats

2021 ◽  
Vol 57 (1) ◽  
pp. 194-204
Author(s):  
Opeyemi Samson Osuntokun ◽  
Mary Olabisi Aderoju ◽  
Ifeoluwa Esther Adebisi ◽  
Taiwo Adekemi Abayomi ◽  
Olorunfemi Samuel Tokunbo ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Neurocognitive Impairment ◽  
Adjunctive Treatment ◽  
Cholinergic Neurotransmission ◽  
Male Wistar Rats

The impairment of motor coordination following chronic carbamazepine-levetiracetam adjunctive treatment with evidence of corticocerebellar toxicity in male Wistar rats

2021 ◽  
pp. 147565
Author(s):  
Opeyemi Samson Osuntokun ◽  
Busayo Grace Akingboye ◽  
Gbola Olayiwola ◽  
Taiwo Adekemi Abayomi ◽  
Abiodun Oludele Ayoka
Keyword(s):  
Wistar Rats ◽  
Motor Coordination ◽  
Adjunctive Treatment ◽  
Male Wistar Rats

Hypothalamic–pituitary–testicular axis derangement following chronic phenytoin–levetiracetam adjunctive treatment in male Wistar rats

Andrologia ◽  
2020 ◽  
Vol 52 (11) ◽  
Author(s):  
Opeyemi S. Osuntokun ◽  
Gbola Olayiwola ◽  
Tope G. Atere ◽  
Damilare A. Adekomi ◽  
Kabiru I. Adedokun ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Adjunctive Treatment ◽  
Male Wistar Rats

scholarly journals Hepato-toxicological and lipid profile of male Wistar rats following chronic carbamazepine, gabapentin, and carbamazepine-gabapentin adjunctive treatment

2021 ◽  
Vol 9 (3) ◽  
pp. 289-298
Author(s):  
O.S. Osuntokun ◽  
O.O. Oladokun ◽  
K.I. Adedokun ◽  
T.G. Atere ◽  
G. Olayiwola ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Liver Homogenate ◽  
Density Lipoprotein ◽  
Adjunctive Treatment ◽  
Male Wistar Rats ◽  
Level Of Significance ◽  
To Receive ◽  
Chronic Use

Aim: This study evaluated the hepatotoxicity and lipid profiles of male Wistar rats following chronic carbamazepine (CBZ), gabapentin (GBP) and carbamazepine-gabapentin (CBZ+GBP) adjunctive treatment. Methods: Twenty-eight male Wistar rats were randomized into 4 groups (n = 7) to receive daily oral administration of normal saline (0.2ml), or CBZ (25 mg/kg), or GBP (50 mg/kg), or the sub-therapeutic dose of CBZ (12.5 mg/kg) and GBP (25 mg/kg) combination for 56 days. Thereafter, blood and liver homogenate were subjected to biochemical analysis, while liver tissues were processed for the histomorphological investigation. Data were analysed statistically, while p< 0.05 was taken as level of significance. Results: Activities of alanine phosphatase and aspartate aminotransferase significantly increased in the CBZ and CBZ + GBP treated rat.  CBZ and CBZ + GBP treatments increased the plasma concentration of low-density lipoprotein and total cholesterol. The liver concentration of malondialdehyde increased significantly in all the treated groups relative to control. There were severe vascular congestions in theliver of the CBZ treated rats, this was moderate in the GBP and CBZ + GBP treated rats. Conclusion: Chronic use of CBZ may induce hepatotoxicity and lipid profile derangement, GBP and CBZ + GBP adjunctive treatment may be saver than treatment with CBZ. 

scholarly journals Assessment of the biomarkers of hepatotoxicity following carbamazepine, levetiracetam, and carbamazepine-levetiracetam adjunctive treatment in male Wistar rats

2021 ◽  
Vol 8 ◽  
pp. 592-598
Author(s):  
Opeyemi Samson Osuntokun ◽  
Ademola Adeniyi Babatunde ◽  
Gbola Olayiwola ◽  
Tope Gafar Atere ◽  
Olayemi Olutobi Oladokun ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Adjunctive Treatment ◽  
Male Wistar Rats

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

2020 ◽  
pp. 1-6 ◽  
Author(s):  
Masoud Nasiri ◽  
Saja Ahmadizad ◽  
Mehdi Hedayati ◽  
Tayebe Zarekar ◽  
Mehdi Seydyousefi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Wistar Rats ◽  
Enzymatic Antioxidants ◽  
Acute Response ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
Exercise Induced ◽  
And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

Augurin stimulates food intake in male Wistar rats

2013 ◽  
pp. 1-1
Author(s):  
Michael Patterson ◽  
John Tadross ◽  
Keisuke Suzuki ◽  
Kylie Beale ◽  
Charoltte Boughton ◽  
...  
Keyword(s):  
Food Intake ◽  
Wistar Rats ◽  
Male Wistar Rats

Pengaruh Profilaksis Ekstrak Ubi Jalar Ungu (Ipomoea batatas L.) terhadap Kadar Malondialdehida Hepar Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Karagenan

2018 ◽  
Vol 15 (2) ◽  
pp. 146
Author(s):  
BRILIAN DINANTI ◽  
FITRI HANDAJANI
Keyword(s):  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Wistar Rats ◽  
Group Method ◽  
Control Group ◽  
Intraplantar Injection ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Potato Extract ◽  
Purple Sweet Potato

<p>Liver is an organ with complex metabolism. When the liver is inflamed, cellular immunity will defend against inflammatory agents by stimulating immune cells to produce reactive oxygen species (ROS). Excessive ROS accumulation cause oxydative stress with increased  liver malondialdehyde (MDA) level. Some researches showed that purple sweet potato contain flavonoids (anthocyanins) that functioned as antioxydants. This study aimed to show the prophylactic effect of purple sweet potato extract to the liver MDA level of male Wistar rats induced by carrageenan.</p><p>This study used post-only control group method using 18 male Wistar rats divided into 3 groups: group of rats without treatment, group of rats induced by 0,1 ml of 1% carrageenan by intraplantar injection on day-8, and group of rats given with 872 mg/kgBW of purple sweet potato extract for 7 days and induced by 0,1 ml of 1% carrageenan. In the end of the study, the liver MDA levels were measured by Thio-Barbituric Acid method on each groups.</p><p>The results of One-Way ANOVA test showed there was no significant difference (p = 0,290) between group of rats without treatment (<em>x̅</em>= 207,50) and group of rats induced by carrageenan (<em>x̅</em>=233,17). Then, there is no significant difference (p = 0.978) between group of rats induced by carrageenan and group of rats given with prophylactic purple sweet potato extract and induced by carrageenan (<em>x̅</em>= 232,50).</p><p>The conclusion of this study is giving intraplantar injection of carrageenan can increase liver MDA level insignificantly and giving prophylactic purple sweet potato extract has an effect to decrease the liver MDA level of rats induced by carragenan insignificantly because it contains anthocyanins as antioxidants.</p><p> </p><strong>Keywords: </strong>Liver, <em>Ipomoea batatas</em> L., Malondialdehyde, Anthocyanins

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