scholarly journals Genomics of severe depression and ECT treatment response: scientific rationale, large scale standardised assessment and implementation of a world-wide effort

2021 ◽  
Vol 14 (6) ◽  
pp. 1737
Author(s):  
Bernhard Baune
Keyword(s):  
Treatment Response ◽  
Large Scale ◽  
World Wide ◽  
Severe Depression ◽  
Scientific Rationale

scholarly journals Google matrix analysis of worldwide football mercato

2018 ◽  
Author(s):  
José Lages ◽  
Justin Loye ◽  
Célestin Coquidé ◽  
Guillaume Rollin
Keyword(s):  
Large Scale ◽  
World Wide ◽  
Matrix Analysis ◽  
Two Dimensional ◽  
Network Nodes ◽  
Pagerank Algorithm ◽  
Google Matrix ◽  
Football Clubs ◽  
The World ◽  
Different Types

The worldwide football transfer market is analyzed as a directed complex network: the football clubs are the network nodes and the directed edges are weighted by the total amount of money transferred from a club to another. The Google matrix description allows to treat every club independently of their richness and allows to measure for a given club the efficiency of player sales and player acquisitions. The PageRank algorithm, developed initially for the World Wide Web, naturally characterizes the ability of a club to import players. The CheiRank algorithm, also developed to analyze large scale directed complex networks, characterizes the ability of a club to export players. The analysis in the two-dimensional PageRank-CheiRank plan permits to determine the transfer balance of the clubs in a more subtle manner than the traditional import-export scheme. We investigate the 2017-2018 mercato concerning 2296 clubs, 6698 player transfers, and 147 player nationalities. The transfer balance is determined globally for different types of player trades (defender, midfielder, forward, …) and for different national football leagues. Although, on average, the network transfer flows from and to clubs are balanced, the discrimination by player type draws a specific portrait of each football club.

scholarly journals Prevalence of Depression Symptoms and Associated Sociodemographic and Clinical Correlates Among Syrian Refugees in Lebanon

2020 ◽  
Author(s):  
Hady Naal ◽  
Dana Nabulsi ◽  
Nour El Arnaout ◽  
Lina Abdouni ◽  
Hani Dimassi ◽  
...  
Keyword(s):  
Mental Health ◽  
Large Scale ◽  
Severe Depression ◽  
Depression Symptoms ◽  
Syrian Refugees ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Clinical Correlates ◽  
Syrian Refugee ◽  
Prevalence Of Depression

Abstract Background: Since the outbreak of the Syrian war in 2011, close to 6 million Syrian refugees have escaped to Syria’s neighbouring countries, including Lebanon. Evidence suggests rising levels of mental health disorders among Syrian refugee populations. Yet, to the best of our knowledge, large-scale studies addressing the mental health of adult Syrian refugees in Lebanon are lacking. Aims: We examined the prevalence of depression symptoms, which represent a common and debilitating mental health disorder among Syrian refugee populations in Lebanon, along with their sociodemographic and clinical correlates.Methods: A cross-sectional survey design was conducted as part of a collaborative project-“Sijilli”- led by the Global Health Institute at the American University of Beirut (Beirut, Lebanon) across 4 informal tented settlements for refugees (Beirut, Bekaa, North, South) in Lebanon among adult Syrian refugees (≥18), over a period extending from 2018 to 2020. The survey inquired about participants’ sociodemographic and clinical characteristics, and screened participants for symptoms of depression through sequential methodology using the Patient Health Questionnaire (PHQ-2 and PHQ-9). Results: A total of 3255 adult Syrian refugees were enrolled in the study. Of those refugees, only 51.6% (n=1678) screened positive on the PHQ-2 and were therefore eligible to complete the PHQ-9. The PHQ-9 analysis revealed high prevalence (25%) of moderate to severe depression in the total sample, suggestive of high probability for major depression disorder (MDD). Further analyses indicate that being ≥45 years of age (OR 1.70, 95% CI 1.22-2.36), a woman (OR 1.35, 95% CI 1.07-1.69), divorced/separated (OR 3.32, 95% CI 1.57-7.01), reporting a neurological (OR 1.77, 95% CI 1.20-2.61) or a mental health condition (OR 5.30, 95% CI 2.40-11.66) are major risk factors for MDD.Conclusion: Our study suggests that one in four Syrian refugees in Lebanon have probable MDD, and our findings have important public health and clinical implications on refugee health. There is a need to enhance screening efforts, to improve access and referral to mental health services, and to improve post-migration factors among Syrian refugees in Lebanon.

The Earth Is (Still) Our Mother

2021 ◽  
pp. 115-125
Author(s):  
Chad S. Hamill
Keyword(s):  
Climate Change ◽  
Large Scale ◽  
World Wide ◽  
Climate Science ◽  
Indigenous Communities ◽  
Ecological Knowledge ◽  
Small Islands ◽  
Adaptive Power ◽  
Circumpolar Arctic ◽  
European Colonialism

As many large-scale protests by Indigenous people have articulated, lands inhabited by Indigenous communities (such as desert margins, small islands, lakes and rivers, high-altitude zones, and the circumpolar Arctic) are particularly vulnerable to the dramatic shifts in climate currently underway. The delicate ecosystems upon which Indigenous communities rely are in flux, and the accelerating rate of climate change—outpacing the direst scientific projections—amounts to a crisis that is every bit as threatening as the legacy of European colonialism. Fortunately, for millennia Indigenous communities have cultivated an intimate awareness of their ecology and have remained, throughout the era of world-wide industrial devastation, adept at adapting to environmental change. This awareness and adaptive power has been discussed within the framework of Traditional Ecological Knowledge (TEK). Using traditional stories and songs in Indigenous communities as a touchstone, this chapter will explore three interrelated aspects of TEK: (1) its role in assisting Indigenous communities in adapting to the effects of climate change; (2) its potential to inform and influence Western-generated climate science; and (3) its promise as a unifying thread tying Indigenous communities together, strengthening global self-determination.

Marketing in Hypermedia Computer-Mediated Environments: Conceptual Foundations

1996 ◽  
Vol 60 (3) ◽  
pp. 50-68 ◽  
Author(s):  
Donna L. Hoffman ◽  
Thomas P. Novak
Keyword(s):  
World Wide Web ◽  
Large Scale ◽  
World Wide ◽  
Structural Model ◽  
The Internet ◽  
Research Issues ◽  
Computer Mediated ◽  
The World ◽  
Conceptual Foundations

The authors address the role of marketing in hypermedia computer-mediated environments (CMEs). Their approach considers hypermedia CMEs to be large-scale (i.e., national or global) networked environments, of which the World Wide Web on the Internet is the first and current global implementation. They introduce marketers to this revolutionary new medium, propose a structural model of consumer navigation behavior in a CME that incorporates the notion of flow, and examine a series of research issues and marketing implications that follow from the model.

scholarly journals ITALIAN GEOLOGY AND CLIMATE CHANGE IN THE DEEP PAST

2020 ◽  
Author(s):  
Hugh C. Jenkyns
Keyword(s):  
Climate Change ◽  
Large Scale ◽  
World Wide ◽  
Sedimentary Rocks ◽  
Volcanic Eruptions ◽  
Black Shales ◽  
Geological Time ◽  
Anoxic Events ◽  
River Valleys ◽  
Water Character

Mesozoic sedimentary rocks, of both deep- and shallow-water character, are present throughout Italy and well exposed in mountains and river valleys. Detailed studies of these sections by Italian geologists, beginning in the nineteenth century and continuing to this day, have produced a high-resolution biostratigraphy that allows identification of increments of geological time of less than a million years. Early work relied largely on ammonites to define biostratigraphy but was applicable primarily to sediments of Jurassic age. Study of deep-marine pelagic limestones and shales of Cretaceous age were subsequently, in the twentieth century, investigated using planktonic microfossils, the size of a sand grain, and even smaller nannofossils of micron scale. Pioneering work on magnetostratigraphy and cyclostratigraphy, undertaken primarily on Cretaceous sediments cropping out in Marche-Umbria, added further refinement to the measuring of small intervals of time in rock. With this stratigraphic background, distinct lithological and chemical signals, discovered first in Italian sequences, could be recognized world-wide and proven to be of global significance. In particular, the involvement of carbon isotopes has underscored the utility of chemostratigraphy, not only as a further aid to correlation, but also as a testimonial to major environmental change. Most significant in this context are the Cretaceous oceanic anoxic events, whose sedimentary record was first documented from Italy. These events were characterized by the development of organic-rich black shales deposited in waters largely lacking in oxygen during times of extraordinarily high temperatures known as hyperthermals. Hyperthermals, likely driven by supply of carbon dioxide from large-scale volcanic eruptions, illustrate the environmental impact on a planet affected by extreme global warming.

scholarly journals Effect of perceived discrimination on depression and suicidal ideation during the COVID-19 pandemic: a large-scale, repeated-measures study in the All of Us Research Program

2021 ◽  
Author(s):  
Younga H. Lee ◽  
Zhaowen Liu ◽  
Daniel Fatori ◽  
Joshua R. Bauermeister ◽  
Rebecca A. Luh ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Research Program ◽  
Repeated Measures ◽  
Large Scale ◽  
Perceived Discrimination ◽  
Severe Depression ◽  
Health Impact ◽  
The United States ◽  
Inverse Probability Weights ◽  
Patient Health

AbstractObjectiveThe COVID-19 pandemic has coincided with an increase in depressive symptoms as well as a growing awareness of health disparities and discrimination against racial and ethnic minority communities in the United States. Here, we examine the mental health impact of perceived discrimination during the pandemic in a large and diverse cohort of the All of Us Research Program.MethodsUsing repeated assessments of 62,651 participants in May to July of 2020, we fitted mixed-effects models to assess the effect of perceived discrimination on moderate to severe depression (Patient Health Questionnaire (PHQ)-9 ≥ 10) and suicidal ideation (PHQ-9 item 9 > 0), and applied inverse probability weights to account for non-random probabilities of completing the voluntary survey.ResultsPerceived discrimination was associated with an increased odds of depression (adjusted odds ratio (aOR) [95% CI]: 1.21 [1.20 -1.22]) and suicidal ideation (1.17 [1.16-1.18]). For depression, the effects were larger in earlier phases of the pandemic (interaction p=8.2×10−5), which varied by main reason for discrimination and self-reported race. Among those who identified race or ancestry as a primary reason for discrimination, Asian and Black participants had 24% and 17% increase in the odds of depression in May of 2020 (1.24 [1.17-1.31] and 1.17 [1.12-1.22]), respectively, versus a 3% and 7% increase in July (1.03 [0.96-1.10] and 1.07 [1.02-1.12]).ConclusionIn this large and diverse sample, increased levels of perceived discrimination were associated with higher odds of depression, particularly during the early phase of the pandemic among participants self-identifying as Asian or Black.

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