Preparation of injectable hydrogels from temperature and pH responsive grafted chitosan with tuned gelation temperature suitable for tumor acidic environment

2018 ◽  
Vol 198 ◽  
pp. 486-494 ◽  
Author(s):  
Natnicha Jommanee ◽  
Chalathorn Chanthad ◽  
Kiattikhun Manokruang
Keyword(s):  
Acidic Environment ◽  
Ph Responsive ◽  
Gelation Temperature ◽  
Injectable Hydrogels

Temperature- and pH-responsive chitosan-based injectable hydrogels for bone tissue engineering

2020 ◽  
Vol 111 ◽  
pp. 110862 ◽  
Author(s):  
K. Lavanya ◽  
S. Viji Chandran ◽  
K. Balagangadharan ◽  
N. Selvamurugan
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Ph Responsive ◽  
Injectable Hydrogels

Metal-Phenolic Encapsulated Mesoporous Silica Nanoparticles for pH-Responsive Drug Delivery and Magnetic Resonance Imaging

2018 ◽  
Vol 232 (9-11) ◽  
pp. 1733-1740 ◽  
Author(s):  
Yan Chen ◽  
Juan Wang ◽  
Jianhua Liu ◽  
Lehui Lu
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Burst Release ◽  
Acidic Environment ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
Mesoporous Silica Nanoparticle ◽  
Longitudinal Relaxivity

Abstract The anticancer drug doxorubicin (DOX) is locked in the mesoporous silica nanoparticle by coating FeIII-TA polymer, and its burst release can be achieved under acidic environment, along with the decreased longitudinal relaxivity. This nanoplatform shows great potential to monitoring the drug delivery process and the fate of the nanocarrier.

scholarly journals PEG-DOX, novel pH responsive prodrug nanoparticles

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
Longyu Li ◽  
Bailun Liu
Keyword(s):  
Carrying Capacity ◽  
Water Solubility ◽  
Circulation Time ◽  
Acidic Environment ◽  
Hydrophobic Core ◽  
Ph Responsive ◽  
Entire Structure ◽  
Tumor Tissues ◽  
Glycol Aldehyde ◽  
Free Doxorubicin

pH responsive prodrug nanoparticles (PEG-DOX) were prepared by attaching free Doxorubicin ( DOX) onto the amphipathic polyethylene glycol-aldehyde (PEG-CHO). The hydrophobic core of PEG-CHO enabled free DOX to be attached, while the hydrophilic outer layer of the carrier enabled the water solubility of the entire structure. This nanocarrier enabled a greater carrying capacity than free DOX, making its circulation time longer. The prodrug remained stable within neutral pH, ensuring its prolonged circulation time, but disassembled rapidly when reaching in the acidic environment of tumor tissues to release the free DOX. The newly designed nanocarriers have the potential to be applied clinically as a future DOX formulation in cancer chemotherapy.

scholarly journals Endosomal pH-Responsive Fe-Based Hyaluronate Nanoparticles for Doxorubicin Delivery

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3547
Author(s):  
Yangmun Bae ◽  
Yoonyoung Kim ◽  
Eun Seong Lee
Keyword(s):  
Hyaluronic Acid ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Drug Carriers ◽  
Acidic Environment ◽  
Ph Responsive ◽  
Ferrous Chloride ◽  
Endosomal Ph ◽  
Dimethylmaleic Anhydride ◽  
Positively Charged

In this study, we report pH-responsive metal-based biopolymer nanoparticles (NPs) for tumor-specific chemotherapy. Here, aminated hyaluronic acid (aHA) coupled with 2,3-dimethylmaleic anhydride (DMA, as a pH-responsive moiety) (aHA-DMA) was electrostatically complexed with ferrous chloride tetrahydrate (FeCl2/4H2O, as a chelating metal) and doxorubicin (DOX, as an antitumor drug model), producing DOX-loaded Fe-based hyaluronate nanoparticles (DOX@aHA-DMA/Fe NPs). Importantly, the DOX@aHA-DMA/Fe NPs improved tumor cellular uptake due to HA-mediated endocytosis for tumor cells overexpressing CD44 receptors. As a result, the average fluorescent DOX intensity observed in MDA-MB-231 cells (with CD44 receptors) was ~7.9 × 102 (DOX@HA/Fe NPs, without DMA), ~8.1 × 102 ([email protected]/Fe NPs), and ~9.3 × 102 ([email protected]/Fe NPs). Furthermore, the DOX@aHA-DMA/Fe NPs were destabilized due to ionic repulsion between Fe2+ and DMA-detached aHA (i.e., positively charged free aHA) in the acidic environment of tumor cells. This event accelerated the release of DOX from the destabilized NPs. Our results suggest that these NPs can be promising tumor-targeting drug carriers responding to acidic endosomal pH.

scholarly journals Thermosensitive alginate–gelatin–nitrogen-doped carbon dots scaffolds as potential injectable hydrogels for cartilage tissue engineering applications

RSC Advances ◽  
2021 ◽  
Vol 11 (30) ◽  
pp. 18423-18431
Author(s):  
Mojgan Ghanbari ◽  
Masoud Salavati-Niasari ◽  
Fatemeh Mohandes
Keyword(s):  
Tissue Engineering ◽  
Gelation Time ◽  
Cartilage Tissue Engineering ◽  
Cartilage Tissue ◽  
Temperature Sensitive ◽  
Gelation Temperature ◽  
Injectable Hydrogels ◽  
Nitrogen Doped ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

The low gelation time (120 s) and gelation temperature at body temperature (37 °C) make oxidized alginate/gelatin/NCDs hydrogels suitable as temperature-sensitive injectable hydrogels for cartilage tissue engineering.

pH Dependent Release Potential of Natural Polymers in Sustained Release of Ornidazole From Colon Targeted Delivery System)

2019 ◽  
Vol 9 (02) ◽  
Author(s):  
Sharma Pankaj ◽  
Tailang Mukul
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Targeted Delivery ◽  
Guar Gum ◽  
Acidic Environment ◽  
Natural Polymers ◽  
Weight Variation ◽  
Curve Determination ◽  
Preformulation Studies

The aim of present work was to prepare colon specific delivery system of Ornidazole using different ratio of shellac, zein and guar gum. From study of various literature it revealed that shellac, zein and guar gum released drug from dosage form at the pH of 6.9, 11.5, 7-9 respectively. The main problem associated with colon targeted drug delivery system is degradation of drug in the acidic environment of stomach to circumvent the present problem different combinations of shellac, zein and guar gum were employed in the formulation of colon targeted tablet. Several preformulation parameters were determined such as melting point, FTIR spectroscopy, preparation of calibration curve, determination of λmax and partition coefficient. After the preformulation studies, next steps were preparation of core tablets, evaluation of core of tablets and coating of tablets. The data obtained from preformulation study seven formulations were developed and evaluated for various parameters. Based on evaluated parameter such as weight variation, friability, dissolution study, invitro drug release etc. the F7 formulation show better results colon targeted tablets. Drug content in F7 formulation was 95% and drug release after 6 hrs was 96%. Formulation containing combination of shellac, zein and guar gum released least amount of drug in the acidic environment of stomach and released most of the drug in colon. It is evide

Inhibition of pipeline steel corrosion in acidic environment using sulphadoxine and pyrimethamine

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Inhibition Efficiency ◽  
Pipeline Steel ◽  
Electrochemical Techniques ◽  
Steel Corrosion ◽  
Acidic Environment ◽  
Inhibitor Concentration ◽  
Adsorption Data ◽  
Corrosion Inhibition Efficiency ◽  
Inhibitive Action ◽  
Sulphadoxine Pyrimethamine

The anti-corrosive properties of sulphadoxine + pyrimethamine (S+P) on the corrosion of pipeline steel in acidic environment were investigated using electrochemical techniques. The results obtained showed an excellent inhibition efficiency which increased with increase in inhibitor concentration. The corrosion inhibition efficiency increased up to 99.04 % at 0.01M S+P and decreased with rise in temperature down to 85.93 % at 333 K and 0.01 M S+P, suggesting a physiosorptive mechanism of adsorption. Also the adsorption data was fitted into Langmuir and Temkin adsorption isotherms, while the inhibitive action was shown to proceed by mixed inhibition mode.

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